The contribution of Tissue Factor Pathway Inhibitor to Thrombin Generation in children receiving Unfractionated Heparin

Hiremath, Mandira; Newall, Fiona; Ignjatović, Vera; Summerhayes, Robyn; Monagle, Paul

doi:10.1016/j.thromres.2010.11.011

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…Its secretion is reduced in ESLD but increased in states of infection and is variable in malignancies. Heparin binds to TFPI and increases its endogenous antithrombotic action by inhibiting Xa by 2‐4 times and thrombin . Heparin is the ideal agent due to the short half‐life (90 minutes) and the easy titration.…”

Section: Discussionmentioning

confidence: 99%

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Perioperative anticoagulation practices for pediatric liver transplantation

Voulgarelis

Vitola

Lerret

et al. 2018

Pediatric Transplantation

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Despite continued advancements in perioperative care for pediatric liver transplant (LT), graft-threatening vascular occlusion events including hepatic artery thrombosis (HAT) and portal vein thrombosis (PVT) remain a source of significant morbidity and mortality. Perioperative anticoagulation is commonly used for the prevention of HAT and PVT, but evidence-based guidelines are lacking. The goals of this survey were to determine the frequency of use of an anticoagulation protocol and to describe variation in anticoagulation practices among pediatric LT centers. The study consisted of an online survey distributed to members of SPLIT. The survey focused on institutional anticoagulation practices employed to reduce the incidence of graft and life-threatening vascular occlusion events. Responses were received from 31 of 39 SPLIT centers. All respondents report using anticoagulation after pediatric LT, and approximately 90% have institutional anticoagulation protocols. Subgroup analysis of high volume pediatric LT centers revealed similar variability in anticoagulation patterns. All participating SPLIT centers reported the use of post-transplant anticoagulation and nearly all use a protocol. However, there is marked variability in the type and dose of anticoagulation as well as the timing of initiation and duration of therapy across centers.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Heparin binds to TFPI and increases its endogenous antithrombotic action by inhibiting Xa by 2-4 times and thrombin. [6][7][8][9] Heparin is the ideal agent due to the short half-life (90 minutes) and the easy titration. It is monitored using PTT or ACT at the bedside, and if bleeding occurs, it can be stopped or reversed effectively.…”

Section: Heparinmentioning

confidence: 99%

Perioperative anticoagulation practices for pediatric liver transplantation

Voulgarelis

Vitola

Lerret

et al. 2018

Pediatric Transplantation

View full text Add to dashboard Cite

show abstract

“…Similar evidence exists with respect to age‐dependent differences in the response to UFH. In vivo studies have demonstrated age‐related differences in the dose–response relationship, a variable ratio of anti‐FIIa to anti‐FXa activity, and age‐dependent differences in the impact of UFH on tissue factor pathway inhibitor release [8–13]. Furthermore, the contribution of renal and hepatic dysfunction to the variable clinical response to LMWH and UFH requires consideration.…”

Section: Introduction and Rationalementioning

confidence: 99%