The contribution of VR1 and CB1 receptors and the role of the afferent vagal pathway in modelling of cardio-respiratory effects of anandamide in rats

Kopczyńska, Beata

doi:10.1016/j.lfs.2007.01.062

Cited by 13 publications

(13 citation statements)

References 39 publications

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“…anandamide which caused a fall in tidal volume (Kopczyńska and Szereda-Przestaszewska, 2006;Kopczyńska, 2007). The rise in V T was abolished by all antagonists: ruthenium red, SB366791 and AM281.…”

Section: Discussionmentioning

confidence: 97%

“…First of all, arvanil did not produce apnoea which was usually observed in cats (Szereda-Przestaszewska and Wypych, 1996;Kopczyńska and Szereda-Przestaszewska, 1998), occasionally in rats after capsaicin (Smith and McQueen, 2001) and always after anandamide i.v. challenges (Lin and Lee, 2002;Kopczyńska and Szereda-Przestaszewska, 2006;Kopczyńska, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…Post-capsaicin respiratory and cardiovascular response is mediated by vanilloid receptors (VR1) (Smith and McQueen, 2001). Intravenous anandamide administration in a dose of 1 mg kg − 1 always caused apnoea (Kopczyńska and Szereda-Przestaszewska, 2006;Kopczyńska, 2007), bradycardia (Lin and Lee, 2002) and hypotension (Varga et al,1995;Lake et al,1997;Malinowska et al, 2001;Kopczyńska, 2007). Apnoea was followed by the fall in tidal volume (Kopczyńska and Szereda-Przestaszewska, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…Apnoeic and hypotensive response to anandamide was mediated by both vanilloid VR1 and cannabinoid CB1 receptors. Post-anandamide decline of tidal volume (V T ) might depend on different type of receptors (Kopczyńska, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Role of VR1 and CB1 receptors in modelling of cardio-respiratory response to arvanil, an endocannabinoid and vanilloid hybrid, in rats

Kopczyńska

2008

Life Sciences

Self Cite

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Role of VR1 and CB1 receptors in modelling of cardio-respiratory response to arvanil, an endocannabinoid and vanilloid hybrid, in rats

Kopczyńska

2008

Life Sciences

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“…Both phytocannabinoids (33,51,60,84,152,181,197) and endocannabinoids (10,117,126,168,180,206) were shown to suppress respiration, and several lines of evidence indicate that this effect is mediated by CB1 receptors. For instance, the CB1 antagonist AM-281 was reported to inhibit the respiratory effects of intravenous applied anandamide in rats (117). Furthermore, intravenous administration of the specific CB1-agonists WIN-55212-2 and CP-55940 induced a similar respiratory depression to that of ⌬9-THC in rats, and the effect of WIN-55212-2 was sensitive to the CB1-antagonist SR141716A (206).…”

Section: Cerebrovascular Actions Of Exogenous and Endogenous Cannabinmentioning

confidence: 99%

Endocannabinoids in cerebrovascular regulation

Benyó

Ruisanchez

Leszl-Ishiguro

et al. 2016

American Journal of Physiology-Heart and Circulatory Physiology

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The cerebral blood flow is tightly regulated by myogenic, endothelial, metabolic, and neural mechanisms under physiological conditions, and a large body of recent evidence indicates that inflammatory pathways have a major influence on the cerebral blood perfusion in certain central nervous system disorders, like hemorrhagic and ischemic stroke, traumatic brain injury, and vascular dementia. All major cell types involved in cerebrovascular control pathways (i.e., smooth muscle, endothelium, neurons, astrocytes, pericytes, microglia, and leukocytes) are capable of synthesizing endocannabinoids and/or express some or several of their target proteins [i.e., the cannabinoid 1 and 2 (CB1 and CB2) receptors and the transient receptor potential vanilloid type 1 ion channel]. Therefore, the endocannabinoid system may importantly modulate the regulation of cerebral circulation under physiological and pathophysiological conditions in a very complex manner. Experimental data accumulated since the late 1990s indicate that the direct effect of cannabinoids on cerebral vessels is vasodilation mediated, at least in part, by CB1 receptors. Cannabinoid-induced cerebrovascular relaxation involves both a direct inhibition of smooth muscle contractility and a release of vasodilator mediator(s) from the endothelium. However, under stress conditions (e.g., in conscious restrained animals or during hypoxia and hypercapnia), cannabinoid receptor activation was shown to induce a reduction of the cerebral blood flow, probably via inhibition of the electrical and/or metabolic activity of neurons. Finally, in certain cerebrovascular pathologies (e.g., subarachnoid hemorrhage, as well as traumatic and ischemic brain injury), activation of CB2 (and probably yet unidentified non-CB1/non-CB2) receptors appear to improve the blood perfusion of the brain via attenuating vascular inflammation. cerebral circulation; endocannabinoids; cannabinoid receptors; TRPV1 channel; neurovascular unit THE CEREBRAL VASCULATURE HAS two main homeostatic functions: 1) to adjust the local blood supply to the eventually rapidly changing metabolic demands of neurons; and 2) to maintain an optimal extracellular environment in the brain. The former function is realized by the regulation of the local cerebral blood flow (CBF), whereas the latter is achieved by the maintenance of the blood-brain barrier (BBB) and related transport mechanisms. The endocannabinoid system has been implicated as an important regulatory component in both of these cerebrovascular functions. The roles of endocannabinoids and cannabinoid receptors in the BBB have been reviewed recently (237). Here we aim to overview our knowledge on the endocannabinoid-mediated regulation of cerebral circulation.

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Anandamide enhances expression of heat shock protein 72 to protect against ischemia–reperfusion injury in rat heart

Shi

2012

J Physiol Sci

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Anandamide (AEA), one of endocannabinoids, has been reported to exhibit a cardioprotective ability to limit the damage produced by ischemia-reperfusion injury. AEA reportedly enhanced heat shock protein 72 (HSP72) and HSP25 expression in lungs to protect against lung inflammation. This study tested the hypothesis that intravenously injected AEA would induce HSP72 in the heart and thus render cardioprotection against ischemia-reperfusion injury in rats. Cardiac expression of HSPs was quantitatively evaluated in rats by Western blot analysis. That intravenously injected AEA 1 mg/kg in vivo induced expression of HSP72, which peaked at 24 h after administration. The enhancement of HSP72 by AEA was blocked by cannabinoid 2 (CB(2)) receptor antagonist AM630, but not cannabinoid 1 (CB(1)) receptor antagonist AM251. Therefore, the rats were induced with a 30-min coronary occlusion followed by a 120-min reperfusion in vivo at 24 h after administration of drugs or vehicle, and then the infarct size was measured. AEA reduced myocardial infarct size compared to control group. Pretreatment with AM630 but not AM251 abolished the infarct size-limiting effect of AEA. Further study demonstrated pretreatment with phosphatidylinositol 3-kinase (PI3K) inhibitor wortmannin, Akt inhibitor MK-2206 and AM630 attenuated phosphorylation of Akt and AEA-induced HSP72 expression. The results suggest that AEA is cardioprotective against ischemia-reperfusion insult through its induction of HSP72, which might be mediated by the PI3K/Akt signaling pathway. These effects were mediated by CB(2) but not CB(1) receptors.

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The contribution of VR1 and CB1 receptors and the role of the afferent vagal pathway in modelling of cardio-respiratory effects of anandamide in rats

Cited by 13 publications

References 39 publications

Role of VR1 and CB1 receptors in modelling of cardio-respiratory response to arvanil, an endocannabinoid and vanilloid hybrid, in rats

Role of VR1 and CB1 receptors in modelling of cardio-respiratory response to arvanil, an endocannabinoid and vanilloid hybrid, in rats

Endocannabinoids in cerebrovascular regulation

Anandamide enhances expression of heat shock protein 72 to protect against ischemia–reperfusion injury in rat heart

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