The contribution of women to radiobiology: Marie Curie and beyond

Abstract

Radiobiology Ionizing radiationTumor radiobiology a b s t r a c t Marie Sklodowska-Curie, an extraordinary woman, a Polish scientist who lived and worked in France, led to the development of nuclear energy and the treatment of cancer. She was the laureate of two Nobel Prizes, the first woman in Europe who obtained the degree of Doctor of Science and opened the way for women to enter fields which had been previously reserved for men only. As a result of her determination and her love of freedom, she has become an icon for many female scientists active in radiation sciences. In 1911, Marie Sklodowska-Curie was awarded her second Nobel Prize for the discovery of radium. Her pioneering work demonstrated that radiation is a powerful tool with a wide range of potential applications, which include a range of diagnostic and therapeutic medical procedures. Marie Curie has left a great deal to the world. Her work led to the development http://dx

Atomic Nanogenerators in Targeted Alpha Therapies: Curie’s Legacy in Modern Cancer Management

“…In radiobiology, three key factors are generally involved in the response of a tumor cell to radiotherapy: proliferation, hypoxia, and cellular radiosensitivity, which itself is determined by DNA repair, cell growth characteristics, and genome instability [88]. Playing a key role in a successful tumor treatment, these factors have to be considered carefully when choosing the radiation source for radiotherapy.…”

“…Another of such indirect effects of irradiation is the abscopal effect for (endo)radiotherapy. This describes the phenomenon by which localized radiation leads to immune-mediated tumor regression, not only in the irradiated area but also in regions that are locally distinct from the radiation field [16,88,90,94,95]. The underlying mechanism is most likely connected to the release of antigens and cytokines after irradiation.…”

Los Curie, la familia Nobel que cambió la ciencia

“…Esta sustancia tenía propiedades químicas completamente únicas, su vida media llegaba a los 1600 años y presentaba una intensidad 3000 veces superior a la del uranio. Anunciaron el des- cubrimiento el 26 de diciembre de 1898 nombrando a la nueva sustancia radio, por sus potentes propiedades radiactivas 11,[19][20][21] . Los Curie habían logrado reconocer dos nuevos elementos radiactivos, pero aún les quedaba el largo trabajo de aislarlos en forma pura.…”

Personalized radiotherapy treatment planning based on functional imaging

“…Early applications were done for skin cancers, although neither biological nor physical properties of ionizing radiation were understood. 1,2 Since then, new developments were implemented to improve the quality and precision of radiation delivery. [3][4][5] One of them was the invention of new imaging techniques e.g.…”