The contributions of anthropology and mitochondrial DNA analysis to the identification of the human skeletal remains of the Australian outlaw Edward ‘Ned’ Kelly

Blau, Soren; Catelli, Laura; Garrone, Florencia; Hartman, Dadna; Romanini, Carola; Romero, Magdalena; Vullo, Carlos

doi:10.1016/j.forsciint.2014.04.009

Cited by 14 publications

(4 citation statements)

References 17 publications

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“…For decades, well‐known properties like small genome size, maternal inheritance, high mutation rate and free from recombination (Cavalli‐Sforza & Feldman, ) make mitochondrial DNA (mtDNA) being the research hotspot in widespread scientific fields, which include evolutionary anthropology (Blau et al, ; Torroni, Achilli, Macaulay, Richards, & Bandelt, ; Underhill & Kivisild, ), archaeology (Ko et al, ; Rothhammer, Fehren‐Schmitz, Puddu, & Capriles, ), medical genetics (Howlett et al, ; Taylor & Turnbull, ) and forensic science (Poletto, Malaghini, Silva, Bicalho, & Braun‐Prado, ; Woerner et al, ). Numerous studies have demonstrated that mtDNA sequence variations accumulated sequentially are unquestionably capable of providing worthy information on genetic structure and phylogenetic relationship of populations (Fagundes et al, ; Schaan et al, ; Torroni et al, ).…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: MtDNA polymorphism analyses in the Chinese Mongolian group: Efficiency evaluation and further matrilineal genetic structure exploration

Lan

Xie

Jin

et al. 2019

Molec Gen & Gen Med

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BackgroundProfiling of mitochondrial DNA is surely to provide valuable investigative clues for forensic cases involving highly degraded specimens or complex maternal lineage kinship determination. But traditionally used hypervariable region sequencing of mitochondrial DNA is less frequently suggested by the forensic community for insufficient informativeness. Genome‐wide sequencing of mitochondrial DNA can provide considerable amount of variant information but can be high cost at the same time.MethodsEfficiency of the 60 mitochondrial DNA polymorphic sites dispersing across the control region and coding region of mitochondrial DNA genome was evaluated with 106 Mongolians recruited from the Xinjiang Uyghur Autonomous Region, China, and allele‐specific PCR technique was employed for mitochondrial DNA typing.ResultsAltogether 58 haplotypes were observed and the haplotypic diversity, discrimination power and random match probability were calculated to be 0.981, 0.972, and 0.028, respectively. Mitochondrial DNA haplogroup affiliation exhibited an exceeding percentage (12.26%) of west Eurasian lineage (H haplogroup) in the studied Mongolian group, which needed to be further verified with more samples. Furthermore, the genetic relationships between the Xinjiang Mongolian group and the comparison populations were also investigated and the genetic affinity was discovered between the Xinjiang Mongolian group and the Xinjiang Kazak group in this study.ConclusionIt was indicated that the panel was potentially enough to be used as a supplementary tool for forensic applications. And the matrilineal genetic structure analyses based on mitochondrial DNA variants in the Xinjiang Mongolian group could be helpful for subsequent anthropological studies.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: MtDNA polymorphism analyses in the Chinese Mongolian group: Efficiency evaluation and further matrilineal genetic structure exploration

Lan

Xie

Jin

et al. 2019

Molec Gen & Gen Med

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“…Without DNA technology, more than half of the identified victims would not have been identified (Ballantyne, 1997). The human mtDNA has been proven to be a useful tool for identification crime victim's especially skeletal remains (Holland and Parsons, 1999;Bender et al, 2000;Rudbeck et al, 2005;Torroni et al, 2006;Palo et al, 2007;Adams et al, 2008;Alaeddini et al, 2010;Shinoda, 2010;Köhnemann and Pfeiffer, 2011;Blau et al, 2014;Hayat et al, 2016;Amer et al, 2017;Gomes et al, 2017;Stenton et al, 2017;Calacal et al, 2018;Mendisco et al, 2018).…”

Section: Control Region Of Mtdna As a Reliable Tool In Forensic Anthrmentioning

confidence: 99%

Application control region of human mitochondrial DNA in forensic anthropology

Samehsalari¹,

Reddy²

2018

Int.J.Mod.Anthrop

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Mitochondrial genome has particular features that make it a valuable forensic marker; first of all it is present in each somatic cell in high numbers. Therefore, it is more resistant to degradation and more stable under unfavorable conditions than nuclear DNA (nDNA) in highly damaged, degraded or very small quantity of the samples. Secondly, the high mutation rate, lack of recombination and the maternal mode of inheritance are features which make the mitochondrial DNA (mtDNA) better choice in situations where nDNA cannot be used for the analysis. Thus, forensic Anthropologists can determine how mitochondrial DNA may be best utilized in skeletal remains or hair shafts, which essentially lack nDNA but contain sufficient amounts of mtDNA. The most extensive mtDNA variations between individuals are found within the Control region or hypervariable regions (HVI, HVII, and HVIII) which allowed individuals to be differentiated and it could provide evidence about the identity of crime victims, especially skeletal remains. In this article we review the feature of mtDNA and its role as a reliable tool in Forensic Anthropology.

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“…The mitochondrial DNA (mtDNA), which is inherited from maternal lineages, possesses properties of simple structure, low recombination rate, and abundance in the copy number. Knowledge about mtDNA phylogeny is essential for performing analysis on evolutionary anthropology, archaeology, medical genetics, and forensic genetics (Taylor and Turnbull, 2005;Kang et al, 2013;Blau et al, 2014;Zhang et al, 2016). As the second genetic legacy, except for nuclear DNA, mtDNA fulfills the demand of profiling fingernails, hair, and poorly degraded samples, thus making the mtDNA a suitable supplementary tool for forensic applications (Xu et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Forensic Feature Exploration and Comprehensive Genetic Insights Into Yugu Ethnic Minority and Northern Han Population via a Novel NGS-Based Marker Set

et al. 2022

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The MPS technology has expanded the potential applications of DNA markers and increased the discrimination power of the targeted loci by taking variations in their flanking regions into consideration. Here, a collection of nuclear and extranuclear DNA markers (totally six kinds of nuclear genetic markers and mtDNA hypervariable region variations) were comprehensively and systematically assessed for polymorphism detections, further employed to dissect the population backgrounds in the Yugu ethnic group from Gansu province (Yugu) and Han population from the Inner Mongolia Autonomous Region (NMH) of China. The elevated efficiencies of the marker set in separating full sibling and challenging half sibling determination cases in parentage tests (iiSNPs), as well as predicting ancestry origins of unknown individuals from at least four continental populations (aiSNPs) and providing informative characteristic-related clues for Chinese populations (piSNPs) are highlighted in the present study. To sum up, different sets of DNA markers revealed sufficient effciencies to serve as promising tools in forensic applications. Genetic insights from the perspectives of autosomal DNA, Y chromosomal DNA, and mtDNA variations yielded that the Yugu ethnic group was genetically close related to the Han populations of the northern region. But we admit that more reference populations (like Mongolian, Tibetan, Hui, and Tu) should be incorporated to gain a refined genetic background landscape of the Yugu group in future studies.

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The contributions of anthropology and mitochondrial DNA analysis to the identification of the human skeletal remains of the Australian outlaw Edward ‘Ned’ Kelly

Cited by 14 publications

References 17 publications

RETRACTED: MtDNA polymorphism analyses in the Chinese Mongolian group: Efficiency evaluation and further matrilineal genetic structure exploration

RETRACTED: MtDNA polymorphism analyses in the Chinese Mongolian group: Efficiency evaluation and further matrilineal genetic structure exploration

Application control region of human mitochondrial DNA in forensic anthropology

Forensic Feature Exploration and Comprehensive Genetic Insights Into Yugu Ethnic Minority and Northern Han Population via a Novel NGS-Based Marker Set

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