The contributions of mesoderm-derived cells in liver development

Yang, Li; Li, Lin‐Chen; Lamaoqiezhong,; Wang, Xin; Wang, Yanchun; Xu, Cheng‐Ran

doi:10.1016/j.semcdb.2018.09.003

Cited by 19 publications

(12 citation statements)

References 191 publications

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“…This occurrence might be caused by the reported senescence of muscle progenitors associated with age [23]. Again, the mesodermal transdifferentiation theory is supported by the presence of the cells in the heart [32], as well as in the liver, the development of which involves significant participation of the mesodermal cells [35], and parts of the gastrointestinal tract, comprised of all three germ layers [36]. However, another explanation for transgenic cell presence needs to be found in the brain, primarily composed of cells of ectodermal origin [37].…”

Section: Discussionmentioning

confidence: 99%

Avian Satellite Cell Plasticity

Jankowski

Mozdziak

Petitte

et al. 2020

Animals

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Adult myogenesis is dependent on a population of precursor cells, located between the sarcolemma and the basal lamina of the muscle fiber. These satellite cells, usually present in a quiescent state, become activated in response to mechanical muscle strain, differentiating and fusing to add new nuclei to enlarging muscles. As their myogenic lineage commitment is induced on demand, muscle satellite cells exhibit a certain amount of plasticity, possibly being able to be directed to differentiate into non-myogenic fates. In this study, myosatellite cells were isolated from chicken muscle samples, characterized in vitro and introduced into developing blastoderms. They were further investigated using fluorescence microscopy, immunohistochemistry and PCR, to determine their location in embryos after three and eighteen days. The results of the in vitro analysis confirmed that the cells obtained from the Pectoralis thoracicus are highly myogenic, based on the expression of Pax7, Myogenin, MyoD, Desmin and the myotube assay. Furthermore, the investigation of satellite cells within the embryo showed their migration to the regions of Pectoralis thoracicus, heart, liver, gizzard, proventriculus, intestine and brain. Overall, the results of the study proved the high myogenicity of chicken Pectoralis thoracicus cell isolates, as well as provided new information about their migration pathways following introduction into the blastocyst. The presence of the introduced LacZ or eGFP transgenes across the embryo, even 20 days after myosatellite cell injection, further supports the notion that satellite cells exhibit significant plasticity, potentially transdifferentiating into non-muscle lineages.

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Section: Discussionmentioning

confidence: 99%

Avian Satellite Cell Plasticity

Jankowski

Mozdziak

Petitte

et al. 2020

Animals

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“…A process of extensive hepatoblast proliferation follows, during which the cells outgrow the liver bud, disrupting the basement membrane, into the STM ( Figure 2C; Douarin, 1975). The other constituents of the organ, sinusoidal endothelial cells (SECs), mesothelial, sub-mesothelial and hepatic stellate cells have a mesoderm origin (reviewed by Yang et al, 2019), as described below. Angioblasts or endothelial progenitor cells are found delimiting the basement membrane (Figure 2A), resembling a loose "necklace" of cells, and were shown to promote liver organogenesis.…”

Section: The Colonization Of the Fl By The Hematopoietic Systemmentioning

confidence: 99%

Crosstalk Between the Hepatic and Hematopoietic Systems During Embryonic Development

Soares-da-Silva

Peixoto

Cumano

et al. 2020

Front. Cell Dev. Biol.

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Hematopoietic stem cells (HSCs) generated during embryonic development are able to maintain hematopoiesis for the lifetime, producing all mature blood lineages. HSC transplantation is a widely used cell therapy intervention in the treatment of hematologic, autoimmune and genetic disorders. Its use, however, is hampered by the inability to expand HSCs ex vivo, urging for a better understanding of the mechanisms regulating their physiological expansion. In the adult, HSCs reside in the bone marrow, in specific microenvironments that support stem cell maintenance and differentiation. Conversely, while developing, HSCs are transiently present in the fetal liver, the major hematopoietic site in the embryo, where they expand. Deeper insights on the dynamics of fetal liver composition along development, and on how these different cell types impact hematopoiesis, are needed. Both, the hematopoietic and hepatic fetal systems have been extensively studied, albeit independently. This review aims to explore their concurrent establishment and evaluate to what degree they may cross modulate their respective development. As insights on the molecular networks that govern physiological HSC expansion accumulate, it is foreseeable that strategies to enhance HSC proliferation will be improved.

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“…Several cell populations participate in this process. These are mainly hepatocytes, but also multiple multipotent and bipotent stem cell populations expressing endodermal or mesenchymal markers [15][16][17][18][19][20].…”

Section: Liver Development and Regenerationmentioning

confidence: 99%

Differentiation of Cells Isolated from Afterbirth Tissues into Hepatocyte-Like Cells and Their Potential Clinical Application in Liver Regeneration

Michalik

Gładyś

Czekaj

2020

Stem Cell Rev and Rep

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Toxic, viral and surgical injuries can pose medical indications for liver transplantation. The number of patients waiting for a liver transplant still increases, but the number of organ donors is insufficient. Hepatocyte transplantation was suggested as a promising alternative to liver transplantation, however, this method has some significant limitations. Currently, afterbirth tissues seem to be an interesting source of cells for the regenerative medicine, because of their unique biological and immunological properties. It has been proven in experimental animal models, that the native stem cells, and to a greater extent, hepatocyte-like cells derived from them and transplanted, can accelerate regenerative processes and restore organ functioning. The effective protocol for obtaining functional mature hepatocytes in vitro is still not defined, but some studies resulted in obtaining functionally active hepatocyte-like cells. In this review, we focused on human stem cells isolated from placenta and umbilical cord, as potent precursors of hepatocyte-like cells for regenerative medicine. We summarized the results of preclinical and clinical studies dealing with the introduction of epithelial and mesenchymal stem cells of the afterbirth origin to the liver failure therapy. It was concluded that the use of native afterbirth epithelial and mesenchymal cells in the treatment of liver failure could support liver function and regeneration. This effect would be enhanced by the use of hepatocyte-like cells obtained from placental and/or umbilical stem cells.

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The contributions of mesoderm-derived cells in liver development

Cited by 19 publications

References 191 publications

Avian Satellite Cell Plasticity

Avian Satellite Cell Plasticity

Crosstalk Between the Hepatic and Hematopoietic Systems During Embryonic Development

Differentiation of Cells Isolated from Afterbirth Tissues into Hepatocyte-Like Cells and Their Potential Clinical Application in Liver Regeneration

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