The control of lymphoid leukosis in a flock White Plymouth Rock chickens

Boer, G. F. de; Vloten, Jacob P. van; Groenendal, J.E.; Maas, H. J. L.; Borm, F.; Hoogerbrugge, A.; Krasselt, Marco

doi:10.1080/01652176.1979.9693717

Cited by 6 publications

(2 citation statements)

References 13 publications

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“…Lymphoid leukosis (LL) is a B-cell lymphoma of chickens taking place during 4 months of age and older (1, 2). The tumors typically involve liver, spleen, and bursa of Fabricius (3) and are usually composed of aggregates of lymphoblasts of B-cell origin with subsequent production of monoclonal IgM (4).…”

Section: Introductionmentioning

confidence: 99%

Endogenous Avian Leukosis Virus in Combination with Serotype 2 Marek's Disease Virus Significantly Boosted the Incidence of Lymphoid Leukosis-Like Bursal Lymphomas in Susceptible Chickens

Mays

Black-Pyrkosz

Mansour

et al. 2019

J Virol

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Lymphoid leukosis (LL)-like lymphoma is a low-incidence yet costly and poorly understood disease of domestic chickens. The observed unique characteristics of LL-like lymphomas are that the incidence of the disease is chicken line dependent; pathologically, it appeared to mimic avian leukosis but is free of exogenous ALV infection; inoculation of the nonpathogenic ALV-E or MDV-2 (SB-1) boosts the incidence of the disease; and inoculation of both the nonpathogenic ALV-E and SB-1 escalates it to much higher levels. This study was designed to test the impact of two new ALV-E isolates, recently derived from commercial broiler breeder flocks, in combination with the nonpathogenic SB-1 on LL-like lymphoma incidences in both an experimental egg layer line of chickens and a commercial broiler breeder line of chickens under a controlled condition. Data from this study provided an additional piece of experimental evidence on the potency of nonpathogenic ALV-E, MDV-2, and ALV-E plus MDV-2 in boosting the incidence of LL-like lymphomas in susceptible chickens. This study also generated the first piece of genomic evidence that suggests host transcriptomic variation plays an important role in modulating LL-like lymphoma formation.

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Section: Introductionmentioning

confidence: 99%

Endogenous Avian Leukosis Virus in Combination with Serotype 2 Marek's Disease Virus Significantly Boosted the Incidence of Lymphoid Leukosis-Like Bursal Lymphomas in Susceptible Chickens

Mays

Black-Pyrkosz

Mansour

et al. 2019

J Virol

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“…Progeny of ALV negative hens of the. WL-HP flock (WL-HF 1 ) were reared in isolation and inoculated with 10 S TCID SO of ALV of subgroups A and B at the age of 8 weeks (De Boer et al, 1979). During lay 1530 eggs were collected from 264 hens.…”

Section: Chickens and Sampling Proceduresmentioning

confidence: 99%

The use of Elisa for detection of exogenous and endogenous avian leukosis viral antigens in basic breeding flocks

Boer¹,

Gielkens²,

Hartog³

et al. 1983

Avian Pathology

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SUMMARYAn enzyme-linked immunosorbent assay (ELISA) for avian leukosis/ sarcoma virus (ALV) group-specific (gs) antigens was used to study the identification of hens which congenitally excrete exogenous ALV. The sensitivity of this assay was compared with that of the phenotypic mixing test (PMT) and the direct complement fixation test (CFT) by testing limiting dilutions of purified avian myeloblastosis virus (AMV), embryo homogenates and albumens. About 0.4 ng/ml of purified AMV protein could be detected by ELISA and 23.8 ng/ml of AMV protein was demonstrable by the CFT. The lowest levels of gs-antigen detection corresponded with about 100 median tissue culture infectious doses (TCID 50 ) of infectious ALV. Albumens and embryos of three White Leghorn flocks and one White Plymouth Rock flock were tested for the presence of avian leukosis virus (ALV) gs-antigens by the complement fixation test (CFT) and the enzyme-linked immunosorbent assay (ELISA) and exogenous ALV employing the phenotypic mixing test (PMT). The highest number of ALVgs antigen positive samples of egg albumens was obtained by the ELISA. In embryo homogenates prepared from eggs of the four flocks under study 100% scores for gs-antigens were obtained by ELISA. A differentiation between gs-antigens of endogenous and exogenous ALV was made by testing of supernatant fluids after one chick embryo fibroblast passage of the C/E phenotype. Endogenous viral (ev) genes leading to the expression of endogenous ALV gs-antigens were apparently present in practically all chickens of the four flocks under study. Complete endogenous ALV (subgroup E) was detected in embryos (41%) from the White Plymouth Rock grandparent flock, but was not found in embryos of two White Leghorn basic breeder flocks. The results indicate that both flocks of White Leghorn chickens are endowed with ev 3 genes. Circumstantial evidence was obtained for the prevalence of endogenous ALV gs-antigens in albumen samples of eggs from flocks with gs + chf + and V-E + phenotype respectively.

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Approaches to Control Avian Lymphoid Leukosis

Boer

1987

Developments in Veterinary Virology

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The control of lymphoid leukosis in a flock White Plymouth Rock chickens

Cited by 6 publications

References 13 publications

Endogenous Avian Leukosis Virus in Combination with Serotype 2 Marek's Disease Virus Significantly Boosted the Incidence of Lymphoid Leukosis-Like Bursal Lymphomas in Susceptible Chickens

Endogenous Avian Leukosis Virus in Combination with Serotype 2 Marek's Disease Virus Significantly Boosted the Incidence of Lymphoid Leukosis-Like Bursal Lymphomas in Susceptible Chickens

The use of Elisa for detection of exogenous and endogenous avian leukosis viral antigens in basic breeding flocks

Approaches to Control Avian Lymphoid Leukosis

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