The control of prostaglandin production by the endometrium in relation to luteolysis and menstruation

Poyser, N.L.

doi:10.1016/0952-3278(95)90115-9

Cited by 147 publications

(104 citation statements)

References 451 publications

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“…Once these are present, OXT binding to its receptor drives pulsatile release of PGF 2α , so starting the process of luteolysis (Poyser 1995, McCracken et al 1999. The initial increase in OXTR is independent of oestradiol regulation (Robinson et al 1999, Leung & Wathes 2000, Mann et al 2013.…”

Section: Discussionmentioning

confidence: 99%

BVDV alters uterine prostaglandin production during pregnancy recognition in cows

Cheng¹,

Abudureyimu²,

Oguejiofor³

et al. 2016

Reproduction

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Embryonic mortality in cows is at least in part caused by failure of pregnancy recognition (PR). Evidence has shown that bovine viral diarrhoea virus (BVDV) infection can disrupt pregnancy. Prostaglandins (PG) play important roles in many reproductive processes, such as implantation. The aim of this study was to investigate the effect of BVDV infection on uterine PG production and PR using an in vitro PR model. Bovine uterine endometrial cells isolated from ten BVDV-free cows were cultured and treated with 0 or 100 ng/mL interferon-τ (IFNT) in the absence or presence of non-cytopathic BVDV (ncpBVDV). PGF 2α and PGE 2 concentrations in the spent medium were measured using radioimmunoassays, and in the treated cells expression of the genes associated with PG production and signalling was quantified using qPCR. The results showed that the IFNT challenge significantly stimulated PTGS1 and PTGER3 mRNA expression and PGE 2 production; however, these stimulatory effects were neutralised in the presence of ncpBVDV infection. ncpBVDV infection significantly increased PTGS1 and mPGES1 mRNA expression and decreased AKR1B1 expression, leading to increased PGE 2 and decreased PGF 2α concentrations and an increased PGE 2 :PGF 2α ratio. The other tested genes, including PGR, ESR1, OXTR, PTGS2, PTGER2 and PTGFR, were not significantly altered by IFNT, ncpBVDV or their combination. Our study suggests that BVDV infection may impair PR by (1) inhibiting the effect of IFNT on uterine PG production and (2) inducing an endocrine switch of PG production from PGF 2α to PGE 2 to decrease uterine immunity, thereby predisposing the animals to uterine disease.Reproduction (2016) 151 605-614

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Section: Discussionmentioning

confidence: 99%

BVDV alters uterine prostaglandin production during pregnancy recognition in cows

Cheng¹,

Abudureyimu²,

Oguejiofor³

et al. 2016

Reproduction

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“…It is associated with diseases such as diabetes (4), osteoporosis (5,6), and menstrual disorder (7). However, it is mostly known for its effect on the female reproductive system.…”

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confidence: 99%

An Aldose Reductase with 20α-Hydroxysteroid Dehydrogenase Activity Is Most Likely the Enzyme Responsible for the Production of Prostaglandin F2α in the Bovine Endometrium

Madore¹,

Harvey

Parent

et al. 2003

Journal of Biological Chemistry

146

118

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Prostaglandins are important regulators of reproductive function. In particular, prostaglandin F2␣ (PGF 2␣ ) is involved in labor and is the functional mediator of luteolysis to initiate a new estrous cycle in many species. These actions have been extensively studied in ruminants, but the enzymes involved are not clearly identified. Our objective was to identify which prostaglandin F synthase is involved and to study its regulation in the endometrium and in endometrial primary cell cultures. The expression of all previously known prostaglandin F synthases (PGFSs), two newly discovered PGFS-like genes, and a 20␣-hydroxysteroid dehydrogenase was studied by Northern blot and reverse transcription PCR. These analyses revealed that none of the known PGFS or the PGFS-like genes were significantly expressed in the endometrium. On the other hand, the 20␣-hydroxysteroid dehydrogenase gene was strongly expressed in the endometrium at the time of luteolysis. The corresponding recombinant enzyme has a K m of 7 M for PGH 2 and a PGFS activity higher than the lung PGFS. This enzyme has two different activities with the ability to terminate the estrous cycle; it metabolizes progesterone and synthesizes PGF 2␣ . Taken together, these data point to this newly identified enzyme as the functional endometrial PGFS.Prostaglandins are local mediators acting through paracrine or autocrine mechanisms. Prostaglandins are produced from arachidonic acid liberated from phospholipid stores through the action of phospholipases. Arachidonic acid is then converted into prostaglandin H 2 (PGH 2 ), 1 the common precursor of all prostaglandins, through the cyclooxygenase and peroxydase activities of prostaglandin H synthase (PGHS). There are two PGHS: PGHS1 and PGHS2. These enzymes (also known as Cox-1 and Cox-2), which have been identified some 10 years ago, are still extensively studied. Because PGH 2 is the common precursor of all subtypes of prostaglandins and because these prostaglandin isotypes cause different and even opposing actions, the pathways leading to their individual formation need to be identified.Prostaglandin F2␣ (PGF 2␣ ) is involved in several physiological processes including pressure regulation in the eye (1), vasoconstriction (2), and renal filtration (3). It is associated with diseases such as diabetes (4), osteoporosis (5, 6), and menstrual disorder (7). However, it is mostly known for its effect on the female reproductive system. In mice, gene knockout of the FP receptor (the receptor for PGF 2␣ ) leads to a failure in the initiation of labor (8). For most mammalian species, the production of PGF 2␣ by the uterus is involved in the regulation of the ovarian cycle. This prostaglandin acts on the corpus luteum, initiating its regression (luteolysis) and leading to termination of the estrous cycle or of pregnancy (reviewed in Ref. 9). The regulation of PGF 2␣ production at the critical period of luteolysis or recognition of pregnancy has been studied extensively in ruminants. In cattle, PGF 2␣ is mainly synthesized by epit...

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“…Accordingly, it has been shown that different prostaglandin isomerases are functionally associated with cyclooxygenase 1 and cyclooxygenase 2 when transfected into HEK-293 cells (Murakami et al, 2000;Tanioka et al, 2000). The activity of cyclooxygenase can be blocked by non-steroidal anti-inflammatory drugs (NSAIDs) (Poyser, 1995). Selective inhibitors for the cyclooxygenase 2 isoform have recently been developed.…”

Section: Introductionmentioning

confidence: 99%

“…Prostaglandins are important regulators of reproductive events including ovulation, implantation, parturition, luteolysis and recognition of pregnancy (Poyser, 1995;Dubois et al, 1998). In ruminants, PGF 2␣ originating from the endometrium is responsible for luteolysis (McCracken et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the contribution of cyclooxygenase 1 and cyclooxygenase 2 to the production of PGE2 and PGF2 alpha in epithelial cells from bovine endometrium

Parent

Villeneuve²,

Fortier³

2003

Reproduction

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In ruminants, the production of prostaglandins by the endometrium is critical for recognition of pregnancy. In the absence of an embryonic signal, luteolytic pulses of PGF 2␣ are released by the uterus. In contrast, the presence of a viable conceptus reduces the production of PGF 2␣ relative to PGE 2 and prevents luteolysis through the release of trophoblastic interferon (IFN-). Initially, it was thought that epithelial and stromal endometrial cells were specialized in the production of a single type of prostaglandin. However, purified cell populations of both types of cell can produce PGF 2␣ and PGE 2 ; therefore, selective production of PGF 2␣ and PGE 2 must be regulated within each type of cell. Two distinct prostaglandin synthases, cyclooxygenase 1 and cyclooxygenase 2, are involved in prostaglandin production and each may catalyse the production of a different prostaglandin. This possibility was investigated in cultured epithelial cells from bovine endometrium. Cells were treated with oxytocin or arachidonic acid, and expression of cyclooxygenase 1 and cyclooxygenase 2 proteins was monitored over time and correlated with prostaglandin accumulation. Cells were also treated with increasing doses of inhibitors of cyclooxygenase 1 or cyclooxygenase 2 (nonsteroidal anti-inflammatory drugs; NSAIDs) with or without arachidonic acid or oxytocin: flurbiprofen (0-50 mol l −1 ) was used as a non-selective inhibitor; valeryl salicylate (0-500 mol l −1 ) was used as a cyclooxygenase 1 inhibitor and NS-398 (0-1 mol l −1 ) was used as a cyclooxygenase 2 inhibitor. After stimulation with arachidonic acid or oxytocin, prostaglandin production and expression of cyclooxygenase 2 protein were increased. All inhibitors were able to block basal and stimulated prostaglandin production. These results indicate that in endometrium most, if not all, prostaglandin production is probably processed through cyclooxygenase 2.

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The control of prostaglandin production by the endometrium in relation to luteolysis and menstruation

Cited by 147 publications

References 451 publications

BVDV alters uterine prostaglandin production during pregnancy recognition in cows

BVDV alters uterine prostaglandin production during pregnancy recognition in cows

An Aldose Reductase with 20α-Hydroxysteroid Dehydrogenase Activity Is Most Likely the Enzyme Responsible for the Production of Prostaglandin F2α in the Bovine Endometrium

Evaluation of the contribution of cyclooxygenase 1 and cyclooxygenase 2 to the production of PGE2 and PGF2 alpha in epithelial cells from bovine endometrium

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