“…After vagotomy the response to secretin in dogs was unchanged (Henriksen, 1969;Konturek, Becker & Thompson, 1974;Debas, Konturek & Grossman, 1975), 1 decreased (Magee, Fragola & White, 1965;Lenninger, Magee & White, 1965), or increased (Tankel & Hollander, 1958;Moreland & Johnson, 1971). In man a significant decrease in the response to secretin has been reported (Wormsley, 1972) whilst in anaesthetized cats the response was either decreased or unchanged (Harper & Vass, 1941). The reasons for these differences are not clear, but may be related to the experimental techniques, the type of fistula used and the method of collecting pancreatic juice, the purity of the secretin used and the method of its administration (by bolus or continuous infusion (at maximal or submaximal rates)) and the length of time which had elapsed since the vagotomy was performed.…”