The Controlling Nutritional Status (CONUT) Score and Prognosis in Malignant Tumors: A Systematic Review and Meta-Analysis

Chen, Junhao; Song, Peng; Peng, Zhou; Liu, Zhenghuan; Yang, Lei; Wang, Linchun; Zhou, Jing; Dong, Qiang

doi:10.1080/01635581.2022.2059091

Cited by 17 publications

(11 citation statements)

References 96 publications

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“…As time has passed, we have realised that it analyses not only nutritional but also clinical risk and prognosis, due to the fact that it identifies the nutritional risk of the cell stemmed from illness and treatments, which is reflected on clinical risk of the patient. Many articles have proved results in accordance to this in many environments, including cancer (7) , CVD (8) and COVID-19 (9) .…”

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confidence: 69%

Letter to the editor concerning the article: reflections on a seminal article on malnutrition published in the British Journal of Nutrition, 2004

Ulibarri¹,

Bengelloun²

2022

Br J Nutr

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authors talk about usefulness of the Malnutrition Universal Screening Tool (MUST).Concerning this tool and its usefulness, we acknowledge the great impact it has had worldwide. However, we think that referring to MUST as a "screening" tool is conceptually inappropriate if we accept WHO's description of screening, which requires the use of presymptomatic parameters 1 , 2 . The application of anthropometric variables, such as loss of weight in the last 3-6 months or body mass index (BMI), implies arriving late to identifying the problem and would more accurately refer to diagnosis, rather than screening, of malnutrition that has been for a long time present and has already harmed the patient. Moreover, this tool operates both with objective and subjective parameters.

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confidence: 69%

Letter to the editor concerning the article: reflections on a seminal article on malnutrition published in the British Journal of Nutrition, 2004

Ulibarri¹,

Bengelloun²

2022

Br J Nutr

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“…Ethical approval for the study was obtained from the University of Health Sciences, Bursa Sehir Training & Research Hospital ethical committee (2023-12/7). The patients were classified according to CONUT scores as low (0-4) and High (5)(6)(7)(8)(9)(10)(11)(12), and further classified as Normal (0-1), Mild (2-4), Moderate (5-9), and High (9)(10)(11)(12). The data was compared among the groups.…”

Section: Methodsmentioning

confidence: 99%

“…A higher CONUT score implies poor nutritional status, with higher scores linked to more significant morbidity and mortality. CONUT scores were classified as low (0-4) and High (5)(6)(7)(8)(9)(10)(11)(12), and further classified as Normal (0-2), Mild (3-4), Moderate (5-9), and High (9-12).…”

Section: Calculationsmentioning

confidence: 99%

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Assessment of nutritional status and clinical outcomes: A comprehensive retrospective analysis of critically ill patients

Özkan,

Koca,

Tekeli

2023

Medicine

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Assessing nutritional status is vital for understanding and managing patients’ clinical conditions. Controlling Nutritional Status (CONUT) score is one of the most frequently used scores that evaluate caloric status, protein reserve, and immunological response estimation. This study assesses the critically ill patients’ nutritional status and its relationship with patient-related factors and mortality. Electronic medical records of 1687 Intensive Care Unit (ICU) patient files were reviewed from January 2019 to May 2023 retrospectively. Patient demographic information, clinical characteristics, and laboratory data were extracted and anonymized for analysis. The patients were divided according to the CONUT scores, and retrieved data were compared. The study population’s demographic features and clinical outcomes were stratified by CONUT scores. The gender distribution was similar; however, there was a significant age difference between the Low-CONUT and High-CONUT groups (P < .001). High CONUT values are linked to an increased risk of death, intubation, age, APACHE-II scores, and the number of comorbidities. Malnutrition is prevalent in ICU patients with gastrointestinal illnesses and urogenital system disorders, including infections. Patients with a high CONUT score at admission had an increased risk of ICU death even after correcting for covariates. The CONUT score is a trustworthy and practical tool for assessing ICU patients’ nutritional status, which is highly associated with ICU mortality. Patients admitted to the ICU with gastrointestinal, urogenital, or infectious disorders should have their nutritional condition assessed carefully. According to our study, the rate of intubated patients admitted to the intensive care unit is higher in malnourished patients. This suggests it should be reviewed in clinical settings, particularly in elderly, frail patients and those with numerous comorbidities.

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“…The CONUT score has been proven not only to correlate with malnutrition grade [ 11 ] but also to have a high predictive value concerning clinical outcomes and morbidity. For example, in patients with cancer, a higher CONUT score predicts a lower overall survival, a lower progress/recurrence-free survival, and a lower cancer-specific survival after surgery [ 15 , 16 ], and a similar predictive value has also been observed for non-solid tumors and other hematologic disorders [ 17 , 18 , 19 ]. However, the CONUT score has also been investigated as a predictor of morbidity or mortality in various conditions other than malignancies, for example, in patients undergoing liver transplant [ 20 ] or heart bypass surgery [ 21 ], in patients with acute heart failure [ 22 ], or in patients with pulmonary embolism [ 23 ].…”

Section: Introductionmentioning

confidence: 97%

COntrolling NUTritional Status (CONUT) as Predictive Score of Hospital Length of Stay (LOS) and Mortality: A Prospective Cohort Study in an Internal Medicine and Gastroenterology Unit in Italy

et al. 2023

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Background: Hospital malnutrition affects nearly 30% of patients in medical wards and correlates with worse outcomes. An early assessment is necessary to stratify the risk of short-term outcomes and mortality. The predictive role of COntrolling NUTritional status (CONUT) score in this context has not yet been elucidated in Western countries. We aimed to test CONUT at admission as a predictive score of hospital outcomes, in an Internal Medicine and Gastroenterology Department of an Italian Tertiary Care University hospital. Methods: We prospectively enrolled patients admitted to our center, stratifying them into the four CONUT classes (normal = 0–1; mild = 2–4; moderate = 5–8; severe = 9–12 points) according to serum albumin (g/dL), total lymphocyte count (/mm3), and total cholesterol (mg/dL); the primary outcome measure was length of stay (LOS) and the secondary one was in-hospital mortality. Results: Out of a total of 203 patients enrolled, 44 (21.7%) patients had a normal status (0–1), 66 (32.5%) had a mild impairment (2–4), 68 (33.5%) had a moderate impairment (5–8), and 25 (12.3%) a severe impairment (9–12). The mean LOS was 8.24 ± 5.75 days; nine patients died. A moderate-severe CONUT correlated with a higher LOS at the univariate [HR 1.86 (95% CI 13.9–3.47); p < 0.0001] and multivariate analysis [HR 1.52 (95% CI 1.10–2.09); p = 0.01]. The CONUT score was also a predictor of mortality, with an AUC of 0.831 (95% CI 0.680–0.982) and with an optimal cut-off at 8.5 points. Nutritional supplementation within 48 h from admission correlated with lower mortality [OR 0.12 (95% CI 0.02–0.56) p = 0.006]. Conclusions: CONUT is a reliable and simple predictor of LOS and in-hospital mortality in medical wards.

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The Controlling Nutritional Status (CONUT) Score and Prognosis in Malignant Tumors: A Systematic Review and Meta-Analysis

Cited by 17 publications

References 96 publications

Letter to the editor concerning the article: reflections on a seminal article on malnutrition published in the British Journal of Nutrition, 2004

Letter to the editor concerning the article: reflections on a seminal article on malnutrition published in the British Journal of Nutrition, 2004

Assessment of nutritional status and clinical outcomes: A comprehensive retrospective analysis of critically ill patients

COntrolling NUTritional Status (CONUT) as Predictive Score of Hospital Length of Stay (LOS) and Mortality: A Prospective Cohort Study in an Internal Medicine and Gastroenterology Unit in Italy

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