The Controlling Nutritional Status Score Is a Significant Independent Predictor of Poor Prognosis in Patients With Malignant Pleural Mesothelioma

Takamori, Shinkichi; Toyokawa, Gouji; Taguchi, Kenichi; Edagawa, Makoto; Shimamatsu, Shinichiro; Toyozawa, Ryo; Nosaki, Kaname; Seto, Takashi; Hirai, Fumihiko; Yamaguchi, Masafumi; Fukushima, Shoji; Okamoto, Tatsuro; Takenoyama, Mitsuhiro; Ichinose, Yukito

doi:10.1016/j.cllc.2017.01.008

Cited by 31 publications

(23 citation statements)

References 26 publications

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“…In addition, we hypothesized that emotional support from children contributed to the patients' nutritional condition and investigated the postoperative change in the patients' nutritional status using well-known indices. [20][21][22] As shown in Table 4, the postoperative exacerbation of the nutritional indices, including the PNI, CONUT, and mGPS, in the childless group was significantly greater than that in the child-present group. These nutritional indices and the change in the nutritional status have been reported to be significant prognostic factors in various types of malignancies (including lung cancer), [20][21][22]25 and this evidence would partly explain the reason why having children significantly influenced the postoperative prognosis of the patients in the present study.…”

Section: Discussionmentioning

confidence: 92%

“…In brief, the PNI was calculated as follows: 10 × albumin + 0.005 × lymphocyte count . The CONUT score was defined as shown in Table . The mGPS value was defined as shown in Table .…”

Section: Methodsmentioning

confidence: 99%

“…20 The CONUT score was defined as shown in Table S1. 21 The mGPS value was defined as shown in Table S2. 22 The change in each nutritional index during the year after surgery was expressed as ΔPNI/y, ΔCONUT/y, and ΔmGPS/y.…”

Section: Analyzing the Postoperative Change In The Nutritional Statusmentioning

confidence: 99%

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The significant influence of having children on the postoperative prognosis of patients with nonsmall cell lung cancer: A propensity score‐matched analysis

et al. 2018

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The aim of this study was to elucidate the relationship between family‐associated factors and the postoperative prognosis in patients with nonsmall cell lung cancer (NSCLC). Additionally, we investigated whether having children was associated with the postoperative maintenance of the nutritional status. We selected 438 NSCLC patients who had undergone curative lung resection between 2004 and 2011 at Kyushu University (Fukuoka, Japan), whose family‐associated factors were available. Nutritional indices, including the prognostic nutritional index (PNI), were used to estimate the change in the nutritional status for 1 year after surgery. A propensity score analysis was conducted after adjusting the following variables: sex, age, smoking history, performance status, pathological stage, and histological type. Three hundred patients (68.5%) had both children and partners. Forty‐nine patients (11.2%) only had children, and 56 (12.8%) patients only had a partner. Thirty‐three patients (7.5%) did not have a partner or children. The overall survival (OS) and disease‐free survival (DFS) of the partner‐present and partner‐absent patients did not differ to a statistically significant extent (P = .862 and P = .712, respectively). However, childless patients showed significantly shorter OS and DFS in comparison with patients with children (P = .005 and P = .002, respectively). The postoperative exacerbation of PNI was significantly greater in childless patients than in patients with children (P = .003). These results remained after propensity score matching. Childless patients had a significantly poorer postoperative prognosis than those with children. Surgeons caring for childless NSCLC patients should be aware of the poorer postoperative outcomes in this population.

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Section: Discussionmentioning

confidence: 92%

“…In brief, the PNI was calculated as follows: 10 × albumin + 0.005 × lymphocyte count . The CONUT score was defined as shown in Table . The mGPS value was defined as shown in Table .…”

Section: Methodsmentioning

confidence: 99%

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The significant influence of having children on the postoperative prognosis of patients with nonsmall cell lung cancer: A propensity score‐matched analysis

et al. 2018

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“…16,17) The detailed mechanism and clinical significance of the inflammatory response have been fully described elsewhere. 15,18) In the present study, only the PLR and EORTC prognostic score were identified as prognostic factors in the univariate analysis. Tagawa et al 18) reported that sex and the PLR were independent predictors of overall survival in patients who underwent EPP for treatment of MPM and advocated the use of a new prognostic score using the PLR.…”

Section: Discussionmentioning

confidence: 99%

“…Appropriate patient selection is also important when undertaking multimodal therapy. Many recent reports have described the use of prognostic factors involving inflammatory markers such as combinations of neutrophils, platelets, and lymphocytes; 1,2) the C-reactive protein level; and the nutritional status as indicated by the serum albumin and cholesterol levels 15) in both lung cancer 16,17) and MPM although the cutoff values have not been fully investigated. The EORTC prognostic score 13) has also been assessed.…”

Section: Discussionmentioning

confidence: 99%

Is Pleurectomy/Decortication Superior to Extrapleural Pneumonectomy for Patients with Malignant Pleural Mesothelioma? A Single-Institutional Experience

Miyazaki

Yamasaki

Tsuchiya

et al. 2018

ATCS

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Postoperative Nutritional Status is Predictive of the Survival Outcomes in Patients Undergoing Resection of Stage III Colorectal Cancer

et al. 2021

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Background Preoperative nutritional status is reportedly associated with the clinical outcomes in patients with colorectal cancer (CRC), although it remains inconclusive whether the preoperative nutritional status that may improve after surgery is truly predictive of the survival outcomes of patients with CRC. Methods Clinical records of patients with stage III CRC (n = 821) in whom curative resection had been achieved were retrospectively reviewed and the prognostic impact of nutritional status, determined by the controlling nutritional status (CONUT) score, was analyzed. Results The CONUT undernutrition grade was significantly associated with the overall survival rate (OS) in the original population (P \ 0.0001). By adopting a cut-off value of CONUT score of C 2 and adjustment for clinical variables using the inverse probability treatment weighting methods, the group with a preoperative CONUT score of C 2 showed a worse OS as compared to the groups with a preoperative CONUT score of \ 2( P = 0.037). However, sub-analysis based on the dynamic changes in the CONUT score revealed that sustained malnutrition in the postoperative period was more frequent among patients with preoperative CONUT score of C 2, and that the OS and recurrence-free survival rate (RFS) were significantly correlated with the ''postoperative'' nutritional status, irrespective of the preoperative nutritional status. Patients who showed improvements of the nutritional status after surgery showed a significantly longer OS and RFS. Conclusions Sustained undernutrition or worsening of the nutritional status after colectomy may be associated with a worse OS and RFS after curative resection in patients with stage III CRC.

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The Controlling Nutritional Status Score Is a Significant Independent Predictor of Poor Prognosis in Patients With Malignant Pleural Mesothelioma

Cited by 31 publications

References 26 publications

The significant influence of having children on the postoperative prognosis of patients with nonsmall cell lung cancer: A propensity score‐matched analysis

The significant influence of having children on the postoperative prognosis of patients with nonsmall cell lung cancer: A propensity score‐matched analysis

Is Pleurectomy/Decortication Superior to Extrapleural Pneumonectomy for Patients with Malignant Pleural Mesothelioma? A Single-Institutional Experience

Postoperative Nutritional Status is Predictive of the Survival Outcomes in Patients Undergoing Resection of Stage III Colorectal Cancer

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