The controversial antibacterial activity of graphene-based materials

Hegab, Hanaa M.; ElMekawy, Ahmed; Zou, Linda; Mulcahy, Dennis; Saint, Christopher P.; Ginic‐Markovic, Milena

doi:10.1016/j.carbon.2016.04.046

Cited by 276 publications

(216 citation statements)

References 140 publications

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“…With regard to the biological interactions of nanocarbons in general, the biological inertness of stabilizing agents is important as they can make a crucial impact on overall toxicity. [23,66,67] Nevertheless, it is noteworthy to emphasize that stabilizing agents (and polymeric coagents) may significantly enhance the antibacterial activity of GMs.…”

Section: Influence Of Abiotic (External) Factorsmentioning

confidence: 99%

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Graphene Materials in Antimicrobial Nanomedicine: Current Status and Future Perspectives

Karahan

Wiraja

et al. 2018

Adv Healthcare Materials

183

142

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Graphene materials (GMs), such as graphene, graphene oxide (GO), reduced GO (rGO), and graphene quantum dots (GQDs), are rapidly emerging as a new class of broad-spectrum antimicrobial agents. This report describes their state-of-the-art and potential future covering both fundamental aspects and biomedical applications. First, the current understanding of the antimicrobial mechanisms of GMs is illustrated, and the complex picture of underlying structure-property-activity relationships is sketched. Next, the different modes of utilization of antimicrobial GMs are explained, which include their use as colloidal dispersions, surface coatings, and photothermal/photodynamic therapy agents. Due to their practical relevance, the examples where GMs function as synergistic agents or release platforms for metal ions and/or antibiotic drugs are also discussed. Later, the applicability of GMs in the design of wound dressings, infection-protective coatings, and antibiotic-like formulations ("nanoantibiotics") is assessed. Notably, to support our assessments, the existing clinical applications of conventional carbon materials are also evaluated. Finally, the key hurdles of the field are highlighted, and several possible directions for future investigations are proposed. We hope that the roadmap provided here will encourage researchers to tackle remaining challenges toward clinical translation of promising research findings and help realize the potential of GMs in antimicrobial nanomedicine.

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Section: Influence Of Abiotic (External) Factorsmentioning

confidence: 99%

“…This brings to mind the effect of GO-media interactions for such an observation. [67,135] Adv. [58] However, there are other reports showing antibacterial effect in growth media, [132,133] and also no antibacterial activity in water.…”

Section: Resolving Ongoing Disagreementsmentioning

confidence: 99%

Graphene Materials in Antimicrobial Nanomedicine: Current Status and Future Perspectives

Karahan

Wiraja

et al. 2018

Adv Healthcare Materials

183

142

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“…The biocidal ability of GFNs has been recently reviewed by Hegab et al [51]. In short, it is a function of nanosheet size, surface area and roughness, dispersability, hydrophilicity and functional groups present in the nanomaterial, being three the main mechanisms through which this antibacterial activity occurs: i) membrane disruption by the sharp edges of the sheets and phospholipid extraction, ii) generation of reactive oxygen species (ROS) that destroy proteins, DNA and other cellular components and iii) enclosing the bacterium among the nanosheets, isolating it from the medium and preventing it from consuming nutrients.…”

Section: Secondary Treatmentmentioning

confidence: 99%

Graphene-family nanomaterials in wastewater treatment plants

Suárez-Iglesias

Collado

Oulego

et al. 2017

Chemical Engineering Journal

129

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“…Most researchers believe that monolayer graphene film can inhibit bacterial proliferation on it's surface, even when the bacteria has all the conditions for optimal growth (Li Jinhua et al, 2014, Kurantowicz et al, 2015, Hegab et al, 2016.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of Monolayer Graphene Film to Standardised Staphylococcus Aureus Strains

Gâjâilă¹,

Gâjâilă²,

Tasbac³

et al. 2018

BUASVMCN-VM

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Due to its unique, unanimously recognized properties and biocompatibility, graphene has wide potential applications in biology, biomedical science, environmental agriculture and biotechnology. The antibacterial effect of the graphene is presented in a large number of publications. Most studies reported in the specific literature were aimed mainly at understanding the interaction between graphene and graphene-based materials with cells and bacteria. Even so, there are conflicting results in some cases and there are also numerous controversies regarding the antibacterial effect of monolayer graphene film on different types of substrate.The study is aimed at testing the antibacterial activity of monolayer graphene film on a copper substrate that was covered with a Staphylococcus aureus culture, Gram-positive bacteria recognized for resilience in external environment. The antibacterial activity of the graphene was evaluated via cell-viability test. It has thus been observed that the bacterial suspension's phisical contact with the a large-area graphene produces significant disturbances of the microorganism's vital processes.This study may provide new insights for the better understanding of antibacterial actions of graphene applied on different substrates and opportunities for biomedical applications.

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The controversial antibacterial activity of graphene-based materials

Cited by 276 publications

References 140 publications

Graphene Materials in Antimicrobial Nanomedicine: Current Status and Future Perspectives

Graphene Materials in Antimicrobial Nanomedicine: Current Status and Future Perspectives

Graphene-family nanomaterials in wastewater treatment plants

Antibacterial Activity of Monolayer Graphene Film to Standardised Staphylococcus Aureus Strains

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