The Controversy of Sunscreen Product Exposure: Too Little, Too Much, or Just Right

Nash, John J.; Tanner, Paul R.

doi:10.1007/978-3-319-29382-0_8

Cited by 1 publication

(1 citation statement)

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“…In particular, as far as UV-filters are concerned, Cosmetics Europe—The Personal Care Association (formerly COLIPA) prescribes an application dose of 2 mg/cm 2 . However, this application dose has not been indicated to replicate the consumer use but to guarantee the inter- and intra-laboratory reproducibility of the SPF test [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

In Vitro Evaluation of Sunscreen Safety: Effects of the Vehicle and Repeated Applications on Skin Permeation from Topical Formulations

et al. 2018

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The evaluation of UV-filter in vitro percutaneous absorption allows the estimation of the systemic exposure dose (SED) and the margin of safety (MoS) of sunscreen products. As both the vehicle and pattern of application may affect sunscreen safety and efficacy, we evaluated in vitro release and skin permeation of two widely used UV-filters, octylmethoxycinnamate (OMC) and butylmethoxydibenzoylmethane (BMBM) from topical formulations with different features (oil in water (O/W) emulsions with different viscosity, water in oil (W/O) emulsion, oils with different lipophilicity). To mimic in-use conditions, we carried out experiments repeating sunscreen application on the skin surface for three consecutive days. BMBM release from all these vehicles was very low, thus leading to poor skin permeation. The vehicle composition significantly affected OMC release and skin permeation, and slight increases of OMC permeation were observed after repeated applications. From skin permeation data, SED and MoS values of BMBM and OMC were calculated for all the investigated formulations after a single application and repeated applications. While MoS values of BMBM were always well beyond the accepted safety limit, the safety of sunscreen formulations containing OMC may depend on the vehicle composition and the application pattern.

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Section: Resultsmentioning

confidence: 99%