The Cooperative Effect of Size and Crystallinity Degree on the Resorption of Biomimetic Hydroxyapatite for Soft Tissue Augmentation

Iafisco, Michele; Varoni, Elena Maria; Battistella, Elisa; Pietronave, Stefano; Prat, María; Roveri, Norberto; Rimondini, Lia

doi:10.1177/039139881003301101

Cited by 21 publications

(12 citation statements)

References 28 publications

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“…The bulk Ca/P ratio determinated by ICP was slightly lower than the stoichiometric one (1.67), and a limited amount of carbonate groups (about 1 wt%), derived from dissolved CO 2 in the preparation media and from CO 2 adsorbed onto the materials surface during the storage, was present. The CO 2 amount was evaluated by TGA, according to the weight loss observed between 550 and 950 °C 19. HA exhibited a high SSA in the 150–170 m 2 · g −1 range, which is in agreement with the nanometric size observed by TEM analysis.…”

Section: Resultssupporting

confidence: 74%

Electrostatic Spray Deposition of Biomimetic Nanocrystalline Apatite Coatings onto Titanium

et al. 2011

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Titanium (Ti) and its alloys are widely used to manufacture orthopedic and dental implants due to their excellent mechanical properties and corrosion resistance. Although these materials are bioinert, improvement of biological properties (e.g., bone implant contact) can be obtained by the application of a coating made of nanostructured apatite. The aim of this study was to investigate the applicability of the electrostatic spray deposition (ESD) technique for the deposition of nanostructured apatite coatings onto commercially pure (cp) Ti substrates at room temperature. To that end, poorly crystalline, nano‐sized, carbonate‐apatite plate‐like particles with dimensions similar to the nanocrystals present in bone were synthesized using wet‐chemical precipitation techniques and their physicochemical properties were subsequently characterized thoroughly. The apatite suspensions were optimized for the ESD process in terms of dispersion, aggregation, and stability. Furthermore, relevant ESD processing parameters, including nozzle‐to‐substrate distance, relative humidity in the deposition chamber and deposition time were varied in order to study their effects on coating morphology. Porous films made of agglomerates of nano‐sized apatite particles of ≈50 nm were generated, demonstrating the feasibility of the ESD technique for the deposition of thin apatite coatings with a nano‐sized surface morphology onto titanium substrates. The ability of these nanocrystals to bind therapeutic agents for bone diseases and the capability of ESD to produce coating at physiological conditions makes this work a first step toward the set‐up of coatings for bone implants based on surface‐activated apatite with improved functionality.

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Section: Resultssupporting

confidence: 74%

Electrostatic Spray Deposition of Biomimetic Nanocrystalline Apatite Coatings onto Titanium

et al. 2011

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“…There are several methods to synthesise hydroxyapatite but mainly it is possible to distinguish two types of hydroxyapatite based on the temperature of synthesis: a high-temperature sintered form (>900°C) and a low-temperature precipitate (~37°C). The compounds synthesized at low-temperature exhibit more solubility, much greater surface area, and they are inherently more active in biological systems in contrast to the biologically inert sintered versions [5]. Sintered hydroxyapatite is most commonly used in load-bearing orthopaedic implants, on the other hand it is not bioresorbable as they are stable over the lifetime of the individual.…”

Section: Introductionmentioning

confidence: 99%

Electrospun Nanostructured Fibers of Collagen-Biomimetic Apatite on Titanium Alloy

Iafisco

Foltran

Sabbatini

et al. 2012

Bioinorganic Chemistry and Applications

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Titanium and its alloys are currently the mainly used materials to manufacture orthopaedic implants due to their excellent mechanical properties and corrosion resistance. Although these materials are bioinert, the improvement of biological properties (e.g., bone implant contact) can be obtained by the application of a material that mimics the bone extracellular matrix. To this aim, this work describes a new method to produce nanostructured collagen-apatite composites on titanium alloy substrate, by combining electrospinning and biomimetic mineralization. The characterization results showed that the obtained mineralized scaffolds have morphological, structural, and chemical compositional features similar to natural bone extracellular matrix. Finally, the topographic distribution of the chemical composition in the mineralized matrix evaluated by Fourier Transform Infrared microspectroscopy demonstrated that the apatite nanocrystals cover the collagen fibers assembled by the electrospinning.

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“…In this work, we report a novel polypyrrole (PPy)/TiHA composite comprising concentric 32 layers of conductive PPy and then the wide band gap semiconductor layer of TiHA NPs on 33 wool yarns, where the TiHA NPs are deposited using a bio-inspired method. The resulting 34 fiber-based structure is a potential building block for use in flexible optoelectronic, such as 35 flexible UV detectors and fabric integrated photovoltaics.…”

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confidence: 99%

Biomineralization of a titanium-modified hydroxyapatite semiconductor on conductive wool fibers

et al. 2017

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1Metal ions are frequently incorporated into crystalline materials to improve their 2 electrochemical properties and to confer new physicochemical properties. Naturally-3 occurring phosphate apatite, which is formed geologically and in biomineralization processes, 4 has extensive potential applications and is therefore an attractive functional material. In this 5 study, we generate a novel building block for flexible optoelectronics using bio-inspired 6 methods to deposit a layer of photoactive titanium-modified hydroxyapatite (TiHA) 7 nanoparticles (NPs) on conductive polypyrrole(PPy)-coated wool yarns. The titanium 8 concentration in the reaction solution was varied between 8-50 mol% with respect to the 9 phosphorous, which led to titanate ions replacing phosphate in the hydroxyapatite lattice at 10 levels up to 17 mol%. PPy was separately deposited on wool yarns by oxidative 11 polymerization, using two dopants: (i) antraquinone-2-sulfonic acid to increase the 12 conductivity of the PPy layer and (ii) pyroglutamic acid, to reduce the resistivity of the wool 72TiHAs were synthesized using increasing amounts of the titanium precursor to reach the 73 molar percentage of Ti atoms with respect to P of 8%, 17%, 25% and 50%. The obtained were used to collect diffraction patterns on samples heated at 700°C for 6 hours. 92Complementary analysis was performed on raw powders using the Diamond Light Source 96The structural and microstructural analysis of the samples was performed using the FullProf TiHA NPs were studied after thermal transformation as described by XRD and Raman 119 spectroscopy. Each sample was placed on a potassium-bromide substrate producing minimal 120 background signal, and the potassium-bromide substrate containing the sample was placed on

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The Cooperative Effect of Size and Crystallinity Degree on the Resorption of Biomimetic Hydroxyapatite for Soft Tissue Augmentation

Cited by 21 publications

References 28 publications

Electrostatic Spray Deposition of Biomimetic Nanocrystalline Apatite Coatings onto Titanium

Electrostatic Spray Deposition of Biomimetic Nanocrystalline Apatite Coatings onto Titanium

Electrospun Nanostructured Fibers of Collagen-Biomimetic Apatite on Titanium Alloy

Biomineralization of a titanium-modified hydroxyapatite semiconductor on conductive wool fibers

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