In the classification of the Ministry of Science and Higher Education in the National Project “Nauka” (2018), the concept of MegaScience is the name of a class of unique scientific installations, and in general terms, these are large expensive international scientific and research complexes for solution of actual scientific problems. It is emphasized that world-class breakthrough research is impossible within the framework of one university or organization, without attracting multi-billion budgets. However, the practice of MEPhI shows that it is possible to construct the unique scientific installations and to achieve results comparable to the largest international projects within a university in cooperation with other Russian and foreign organizations.