The CorInnova Implantable Cardiac Assist System for Direct Cardiac Compression

Letsou, George V.; Bolch, Christina M.; Hord, Erica C.; Altman, William C.; Leschinsky, Boris; Criscione, John C.

doi:10.31083/j.rcm2306211

Cited by 5 publications

(3 citation statements)

References 54 publications

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“…(c) Graphic illustration of Corinnova heart assistance device deployment. Adapted with permission under a Creative Commons Attribution 4.0 International License from ref . Copyright 2022 IMR Press.…”

Section: Future Perspectivesmentioning

confidence: 99%

Next-Generation Cardiac Interfacing Technologies Using Nanomaterial-Based Soft Bioelectronics

Han,

Sunwoo,

Park

et al. 2024

ACS Nano

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Cardiac interfacing devices are essential components for the management of cardiovascular diseases, particularly in terms of electrophysiological monitoring and implementation of therapies. However, conventional cardiac devices are typically composed of rigid and bulky materials and thus pose significant challenges for effective long-term interfacing with the curvilinear surface of a dynamically beating heart. In this regard, the recent development of intrinsically soft bioelectronic devices using nanocomposites, which are fabricated by blending conductive nanofillers in polymeric and elastomeric matrices, has shown great promise. The intrinsically soft bioelectronics not only endure the dynamic beating motion of the heart and maintain stable performance but also enable conformal, reliable, and large-area interfacing with the target cardiac tissue, allowing for high-quality electrophysiological mapping, feedback electrical stimulations, and even mechanical assistance. Here, we explore nextgeneration cardiac interfacing strategies based on soft bioelectronic devices that utilize elastic conductive nanocomposites. We first discuss the conventional cardiac devices used to manage cardiovascular diseases and explain their undesired limitations. Then, we introduce intrinsically soft polymeric materials and mechanical restraint devices utilizing soft polymeric materials. After the discussion of the fabrication and functionalization of conductive nanomaterials, the introduction of intrinsically soft bioelectronics using nanocomposites and their application to cardiac monitoring and feedback therapy follow. Finally, comments on the future prospects of soft bioelectronics for cardiac interfacing technologies are discussed.

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Section: Future Perspectivesmentioning

confidence: 99%

Next-Generation Cardiac Interfacing Technologies Using Nanomaterial-Based Soft Bioelectronics

Han,

Sunwoo,

Park

et al. 2024

ACS Nano

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“…The corInnova device has sensing electrodes and operation is triggered by the cardiac activity of the heart exemplifying a good control system. [ 89 ] Less power requirement improves the quality of life of the patient. Transcutaneous power systems have the added advantage of avoiding driveline infections.…”

Section: Key Factors For the Development And In Vivo Implantation Of ...mentioning

confidence: 99%

Artificial Muscles and Soft Robotic Devices for Treatment of End‐Stage Heart Failure

et al. 2023

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Medical soft robotics constitutes a rapidly developing field in the treatment of cardiovascular diseases, with a promising future for millions of patients suffering from heart failure worldwide. Herein, the present state and future direction of artificial muscle‐based soft robotic biomedical devices in supporting the inotropic function of the heart are reviewed, focusing on the emerging electrothermally artificial heart muscles (AHMs). Artificial muscle powered soft robotic devices can mimic the action of complex biological systems such as heart compression and twisting. These artificial muscles possess the ability to undergo complex deformations, aiding cardiac function while maintaining a limited weight and use of space. Two very promising candidates for artificial muscles are electrothermally actuated AHMs and biohybrid actuators using living cells or tissue embedded with artificial structures. Electrothermally actuated AHMs have demonstrated superior force generation while creating the prospect for fully soft robotic actuated ventricular assist devices. This review will critically analyze the limitations of currently available devices and discuss opportunities and directions for future research. Last, the properties of the cardiac muscle are reviewed and compared with those of different materials suitable for mechanical cardiac compression.

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“…The space between the inner layer and the heart is filled with liquid to improve the interaction between the device and the heart. [ 61 ] The device is capable of multifunctional assistance including active compression and passive constraint. [ 62 ] Interestingly, the CorInnova device can be implanted with minimally invasive surgery, causing less postoperative pain and shorter hospital stays for patients.…”

Section: Introductionmentioning

confidence: 99%

Robotic Cardiac Compression Device Using Artificial Muscle Filaments for the Treatment of Heart Failure

Phan,

Davies,

Hoang

et al. 2023

Advanced Intelligent Systems

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Heart failure occurs when the heart cannot pump adequate blood to the body, which afflicts over 60 million people worldwide. Its treatment options include physiotherapy, medication, mechanical heart support, heart surgery, or heart transplantation. Ventricular assist devices have direct blood contact while passive ventricular constraint devices have only modest therapeutic efficacy. Current direct cardiac compression devices are either bulky, require noisy driving pneumatic sources, or are unable to mimic the natural heart motion. This study introduces a robotic cardiac compression device made of soft artificial muscle filaments that can simultaneously produce radial, axial, and torsional movements, potentially augmenting the pumping function of a failing heart. An empirical model is developed to describe the device motion and an artificial pericardium is employed to enable uniform force distribution to the heart and real‐time pressure sensing. The proposed device could deliver a stroke volume of 70 mL at 15 beats per minute, or a cardiac output of 1.05 L min−1, and achieve a peak instantaneous flow rate of 2.8 L min−1 and an output pressure of 50 mmHg. The new devices are highly customizable and experimentally validated with fresh porcine heart. They are expected to inspire future development of nonblood‐contacting cardiac assist devices.

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The CorInnova Implantable Cardiac Assist System for Direct Cardiac Compression

Cited by 5 publications

References 54 publications

Next-Generation Cardiac Interfacing Technologies Using Nanomaterial-Based Soft Bioelectronics

Next-Generation Cardiac Interfacing Technologies Using Nanomaterial-Based Soft Bioelectronics

Artificial Muscles and Soft Robotic Devices for Treatment of End‐Stage Heart Failure

Robotic Cardiac Compression Device Using Artificial Muscle Filaments for the Treatment of Heart Failure

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