The Coronary Vascular System and Associated Medical Devices

Spencer, Julianne H.; Anderson, Sara E.; Lahm, Ryan; Iaizzo, Paul A.

doi:10.1007/978-3-319-19464-6_8

Cited by 3 publications

(2 citation statements)

References 156 publications

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“…Nonetheless, in some cases, women aged below 55 and men younger than 45 experience CAD symptoms 3 . The principal cause of such incidence remains indefinite, although previous studies have reported the contribution of genetic factors in promoting atherosclerosis at younger ages 6 , 24 .…”

Section: Discussionmentioning

confidence: 99%

Associations between low serum levels of ANRIL and some common gene SNPs in Iranian patients with premature coronary artery disease

Taheri Bajgan,

Zahedmehr,

Shakerian

et al. 2024

Sci Rep

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Coronary artery disease (CAD) is the major cause of mortality in the world. Premature development of CAD can be attributed to women under 55 and men under 45. Many genetic factors play a part in premature CAD. Among them, ANRIL, a long noncoding RNA is located at the 9p21 risk locus, and its expression seems to be correlated with CAD. In the current study, premature CAD and control blood samples, with and without Type 2 Diabetes (T2D), were genotyped for six SNPs at the 9p21 locus. Additionally, ANRIL serum expression was assessed in both groups using real-time PCR. It was performed using different primers targeting exons 1, 5–6, and 19. The χ2 test for association, along with t-tests and ANOVA, was employed for statistical analysis. In this study, we did not find any significant correlation between premature coronary artery disease and rs10757274, rs2383206, rs2383207, rs496892, rs10757278 and rs10738605. However, a lower ANRIL expression was correlated with each SNP risk genotype. Despite the correlation between lower ANRIL expression and CAD, Type 2 diabetes was associated with higher ANRIL expression. Altogether, the correlation between ANRIL expression and the genotypes of the studied SNPs indicated that genetic variants, even those in intronic regions, affect long noncoding RNA expression levels. In conclusion, we recommend combining genetic variants with expression analysis when developing screening strategies for families with premature CAD. To prevent the devastating outcomes of CAD in young adults, it is crucial to discover noninvasive genetic-based screening tests.

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Section: Discussionmentioning

confidence: 99%

Associations between low serum levels of ANRIL and some common gene SNPs in Iranian patients with premature coronary artery disease

Taheri Bajgan,

Zahedmehr,

Shakerian

et al. 2024

Sci Rep

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“…The coronary sinus (CS) receives most of the cardiac venous blood 1 . It is composed of layers of endocardium, myocardium and epicardium, a conduction branch, and a node with cells similar to those of the sinus node.…”

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confidence: 99%

Echocardiographic Study of the Coronary Sinus in the Indeterminate Form of Chagas Disease

Machado

Anjos

Rodrigues

et al. 2018

Rev. Soc. Bras. Med. Trop.

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Introduction: We investigated the occurrence of coronary sinus abnormalities in the indeterminate form of Chagas disease (CD). Methods: Differences between the maximum and minimum diameters of the coronary sinus (∆%) on echocardiography were evaluated in individuals with the indeterminate form of CD (n=14) and those without (n=16) CD. The association of the difference with abnormalities detected by echocardiography and myocardial scintigraphy was assessed. Results: The mean Δ% values did not differ significantly between the groups. There was no correlation of the measurements with echocardiographic and myocardial scintigraphy findings. Conclusions: The coronary sinus evaluation revealed no differences between the groups.

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