The correction of the metabolic parameters of msg-induced obesity in rats by 2-[4-(benzyloxy) phenoxy] acetic acid

Konopelniuk, V.; Falalyeyeva, Tetyana; Tsyryuk, Olena; Savchenko, Yuliia; Prybytko, Iryna; Kobyliak, Nazarii; Kovalchuk, Oleksandr; Boyko, A. L.; Arkhipov, V. V.; Moroz, Yurii S.; Li, Ostapchenko

doi:10.1016/j.jnim.2018.07.002

Cited by 4 publications

(3 citation statements)

References 36 publications

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“…(Priyanto et al, 2016; Richard et al, 2019). Furthermore, recent studies reported it to be one of the leading cause of deaths in the world with an annual mortality rate of 2.8–3.4 million (Egedigwe et al, 2016; Priyanto et al, 2016; Victoria et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Obesity and Comorbidity: Could Simultaneous Targeting of esRAGE and sRAGE Be the Panacea?

et al. 2019

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Obesity, a chronic multifaceted disease, predisposes its patients to increased risk of metabolic disorders such as: diabetes mellitus, cardiovascular diseases, dyslipidemia, etc. Recent studies reported it to be amongst the leading causes of deaths in the world. Although several treatment options for obesity abound, many of them have not been able to successfully reverse the existing obesity and metabolic dysregulation. This has therefore warranted the need for either alternative therapies or diversification of the treatment approach for obesity and its comorbidity. When the receptor for advanced glycation end products (RAGE) interacts with its ligand, RAGE-ligand activates an inflammatory signaling cascade, that leads to the activation of nuclear factor kappa B (NF-κB) and transcription of inflammatory cytokines. This action has been associated with the development of obesity and its mediated metabolic dysregulation. In view of the increasing prevalence of obesity globally and the potential threat it places on life expectancy, this article reviewed the promising potentials of targeting endogenous secretory receptor for advanced glycation end products/soluble receptors for advanced glycation end products signaling as a treatment approach for obesity. We carried out a literature search in several electronic data bases such as: Pubmed, Pubmed Central, Google, Google Scholar, Scopus, and Medline from 1980 to 2019 to acquire the status of information concerning this. The article suggests the need for the development of an esRAGE/sRAGE targeted pharmacotherapy as a treatment approach for obesity and its comorbidity.

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Section: Introductionmentioning

confidence: 99%

Obesity and Comorbidity: Could Simultaneous Targeting of esRAGE and sRAGE Be the Panacea?

et al. 2019

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“…The BMI was determined using the formula: BMI = Body weight (g) / body length2 (cm2). Body mass index was classified as follows: (Normal BMI: male [0.45 ± 0.02-0.68 ± 0.05] g/cm2 [12].…”

Section: Determination Of Adiposity and Assessment Of Body Mass Index...mentioning

confidence: 99%

“…Adiposity index was calculated using the formula for Lee index of obesity: Adiposity index = cube root of body weight (g) / body length (cm) noseto-anus length (cm) [12].…”

Section: Adiposity Indexmentioning

confidence: 99%

Adiposity, Atherogenic Index and Lipid Profile of Male Wistar Rats Administered with Kunun-Zaki

Aderonke

Oluwapolola

Olamide

et al. 2022

AJRB

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Aim: Kunun-zaki (KZ) is a highly refreshing local beverage that is commonly consumed both in urban and rural areas. The objective of the study was to investigate the effect of KZ on lipid profile and other markers of cardio-vascular risks in Wistar rats. Methods: Fourteen adult male Wistar rats (mean weight of 150 g) used for the study were randomly divided into 2 groups (Groups A & B) of 7 rats each. The experimental rats in Group A and B were administered daily with 5 mL of distilled water and kunun zaki respectively for a period of 2 weeks. All experimental animals were allowed access to standard feed and water ad libitum. Blood samples were collected and analyzed for total cholesterol (TC), triglyceride (TG), low density lipoprotein- cholesterol (LDL-C), high density lipoprotein- cholesterol (HDL-C), and very low density lipoprotein cholesterol (VLDL-C) using standard biochemical methods. The body mass index (BMI), atherogenic index, and adiposity index were also determined. Liver, kidney and heart were harvested and weighed to determine organ weights. The results were statistically analyzed using Student’s 't’test and by Pearson’s correlation coefficient. All values were presented as mean ± standard error of mean. P< 0.05 was considered significant. Results: While TC, LDL-C, HDL-C concentrations were not significantly different, both TG and VLDL-C concentrations in KZ administered rats were significantly higher compared with control. BMI, antherogenic index and adiposity were not significantly different also when both groups were compared. Conclusion: the results of the study indicate that kunun-zaki does cause modulatory elevation in lipid profile.

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Vitamin D supplementation combined with aerobic physical exercise restores the cell density in hypothalamic nuclei of rats exposed to monosodium glutamate

Muraro

Sbardelotto

Guareschi

et al. 2022

Clinical Nutrition ESPEN

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The correction of the metabolic parameters of msg-induced obesity in rats by 2-[4-(benzyloxy) phenoxy] acetic acid

Cited by 4 publications

References 36 publications

Obesity and Comorbidity: Could Simultaneous Targeting of esRAGE and sRAGE Be the Panacea?

Obesity and Comorbidity: Could Simultaneous Targeting of esRAGE and sRAGE Be the Panacea?

Adiposity, Atherogenic Index and Lipid Profile of Male Wistar Rats Administered with Kunun-Zaki

Vitamin D supplementation combined with aerobic physical exercise restores the cell density in hypothalamic nuclei of rats exposed to monosodium glutamate

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