The Correlation Between Biofilm Formation and Drug Resistance in Nosocomial Isolates of<i> Acinetobacter baumannii</i>

Emami, Shiva; Eftekhar, Fereshteh

doi:10.17795/ajcmi-23954

Cited by 5 publications

(4 citation statements)

References 19 publications

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“…Production of ESBL, MBL by non-biofilm and biofilm producers is presented in Table 2. Despite the maximum ESBL producers being biofilm positive, no significant association (P > 0.05) was found between isolates, which is similar to the findings reported by (34). Furthermore, there was no significant association between MBL production and biofilm formation.…”

Section: Dna Sequencingsupporting

confidence: 85%

Evaluation of blaGES-5 and bla veb-1 genes with multidrug-resistant extend, pandrug resistance patterns (MDR, XDR, PDR), and biofilm formation in Pseudomonas aeruginosa isolates

Ali

Bakir

Haji

et al. 2021

Cell Mol Biol (Noisy-le-grand)

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Pseudomonas aeruginosa is a ubiquitous microorganism that is difficult to treat due to the increasing prevalence of multidrug resistance patterns. A total of 227 samples were taken from different clinical samples during the study period from January 2018 to December 2018. The isolates were identified with antibiotic sensitivity testing with ESBL by the Vitek-2 automated method. MDR, XDR, and PDR were determined. 40 (17.6%) isolates were positive for P. aeruginosa, maximum of ESBL and MBL. Positive isolates were detected in the burn, coexisting ESBL + MBL enzymes in 21 (52.5%) of our isolates. Imipenem followed by Meropenem were found to be effective against ESBL and MBL producers. Resistance was reached between 72-100% to 5 antibiotics. The frequency of PDR, MDR, and XDR were 5%, 50%, and 45%, respectively. The frequency of co-production between MDR, XDR, and PDR with MBL, ESBL, and Biofilm was 35%, 12.5% and 5%, respectively. Among the ESBLs, the frequency of distribution of bla VEB-1gene and blaGES-5 gene was 50% and 40 %, respectively. Bacterial isolates simultaneously carrying blaVEB-1 gene with multiple ?-lactamases of different classes of biofilm, MDR, PDR, and XDR as same as a coexisting blaGES-5 gene. One isolate was detected as new isolates registered in global gene bank as locally P. aeruginosa isolates in Erbil city (LOCUS MN900953). The phylogenetic trees of the blaVEB gene isolates were demonstrated a genotype closely related to others, deposited in GenBank similar to the P. aeruginosa gene; gene sequencing revealed a 99% similarity with other isolates deposited in GenBank.

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Section: Dna Sequencingsupporting

confidence: 85%

Evaluation of blaGES-5 and bla veb-1 genes with multidrug-resistant extend, pandrug resistance patterns (MDR, XDR, PDR), and biofilm formation in Pseudomonas aeruginosa isolates

Ali

Bakir

Haji

et al. 2021

Cell Mol Biol (Noisy-le-grand)

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“…Despite the maximum ESBL producers being biofilm positive, no significant association was found between them, similar to the finding of Emami et al but in contrast with other studies [17, 32, 33]. Conversely, the association between MBL production and biofilm formation was observed to be statistically significant.…”

Section: Discussionsupporting

confidence: 74%

Study of biofilm formation and antibiotic resistance pattern of gram-negative Bacilli among the clinical isolates at BPKIHS, Dharan

2019

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ObjectivesGram-negative bacilli are the common causative agents for community-acquired, nosocomial and opportunistic infections. The recent upsurge of biofilm, as well as beta-lactamases producing strains, have synergistically led to the extensive dissemination of multi-drug resistant gram-negative bacilli. This study was carried out with an intention to detect the biofilm formation by gram-negative bacilli and determine their antibiogram along with the detection of extended-spectrum beta-lactamases (ESBLs) and metallo-beta-lactamases (MBLs) production.ResultsAmong 314 isolates, Escherichia coli (38%) were the predominant isolates followed by Acinetobacter spp. (20%), Klebsiella spp. (16%), and Pseudomonas spp. (12%). Overall, 197 (62.73%) of isolates were biofilm positive. 84 (26.75%) and 51 (16.24%) were confirmed as ESBL and MBL producers respectively. The association between MBL production and biofilm formation was statistically significant (χ2 = 10.20, P value= 0.002) whereas it was insignificant between ESBL and biofilm production (χ2 = 0.006, P-value= 0.937). Most of the biofilm and MBL producing strains were multi-drug resistant.

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“…A recent study conducted by Asaad et al [23], explain that A. baumannii isolates exhibits resistance to ceftazidime, ampicillin/sulbactam, piperacillin/gentamycin, trimethoprim/sulfamethoxazole, and imipenem were significantly more likely to form biofilm in the presence of the genes OmpA, Bap, MDR, and XDR (extensively drugresistant). Another study found that antibioticresistant A. baumannii isolates produced the enzymes such as AmpC beta-lactamases, and extended-spectrum beta-lactamases (ESBLs) to improve biofilm formation [24].…”

Section: Biofilm Formation and Antibiotic Resistancementioning

confidence: 99%

Understanding the biofilm development of Acinetobacter baumannii and novel strategies to combat infection

Naseef Pathoor,

Viswanathan,

Wadhwa

et al. 2024

APMIS

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Acinetobacter baumannii (A. baumannii) is a Gram‐negative, nonmotile, and aerobic bacillus emerged as a superbug, due to increasing the possibility of infection and accelerating rates of antimicrobial agents. It is recognized as a nosocomial pathogen due to its ability to form biofilms. These biofilms serve as a defensive barrier, increase antibiotic resistance, and make treatment more difficult. As a result, the current situation necessitates the rapid emergence of novel therapeutic approaches to ensure successful treatment outcomes. This review explores the intricate relationship between biofilm formation and antibiotic resistance in A. baumannii, emphasizing the role of key virulence factors and quorum sensing (QS) mechanisms that will lead to infections and facilitate insight into developing innovative method to control A. baumannii infections. Furthermore, the review article looks into promising approaches for preventing biofilm formation on medically important surfaces and potential therapeutic methods for eliminating preformed biofilms, which can address biofilm‐associated A. baumannii infections. Modern advances in emerging therapeutic options such as antimicrobial peptide (AMPs), nanoparticles (NPs), bacteriophage therapy, photodynamic therapy (PDT), and other biofilm inhibitors can assist readers understand the current landscape and future prospects for effectively treating A. baumannii biofilm infections.

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The Correlation Between Biofilm Formation and Drug Resistance in Nosocomial Isolates of Acinetobacter baumannii

Cited by 5 publications

References 19 publications

Evaluation of blaGES-5 and bla veb-1 genes with multidrug-resistant extend, pandrug resistance patterns (MDR, XDR, PDR), and biofilm formation in Pseudomonas aeruginosa isolates

Evaluation of blaGES-5 and bla veb-1 genes with multidrug-resistant extend, pandrug resistance patterns (MDR, XDR, PDR), and biofilm formation in Pseudomonas aeruginosa isolates

Study of biofilm formation and antibiotic resistance pattern of gram-negative Bacilli among the clinical isolates at BPKIHS, Dharan

Understanding the biofilm development of Acinetobacter baumannii and novel strategies to combat infection

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