The correlation between controlled attenuation parameter and metabolic syndrome and its components in middle-aged and elderly nonalcoholic fatty liver disease patients

Abstract

This study aims to investigate the correlation between controlled attenuation parameter (CAP) and metabolic syndrome (MetS) and its components in middle-aged and elderly nonalcoholic fatty liver disease (NAFLD) patients.Middle-aged and elderly patients with NAFLD, who visited our hospital from June 2016 to May 2017, were enrolled as study subjects, whereas middle-aged and elderly patients without liver disease were enrolled as controls in the same period. The prevalence of MetS, MetS components, and the different numbers of MetS components were compared among patients with different CAP values.As the CAP value increased, the prevalence of MetS, MetS components, and the different numbers of MetS components significantly increased. The CAP value was positively correlated with the prevalence of MetS, obesity, hypertriglyceridemia, hypertension, hyperglycemia, hyperuricemia, and the number of MetS components, and was negatively correlated with the prevalence of hypo–high-density-lipoprotein cholesterolemia.CAP values are closely correlated to MetS and its components in middle-aged and elder NAFLD patients. CAP may be an indicator of risk of MetS and the severity of metabolic disorders in middle-aged and elderly NAFLD patients.

Predicting Metabolic Syndrome With Machine Learning Models Using a Decision Tree Algorithm: Retrospective Cohort Study

“…The new models of FibroScan (marketed after 2013) can assess the staging of NAFLD using a liver stiffness score (E score) and a liver steatosis score (controlled attenuation parameter [CAP] score). Interestingly, the CAP score alone was found to be a useful indicator of the presence and severity of metabolic syndrome [18]. Using traditional statistical modeling, we previously validated this finding, confirming that the CAP score alone can be used to detect metabolic syndrome with moderate accuracy (area under the receiver operating characteristic curve [ROC] of 0.79), and the accuracy was improved to 0.88 when combined with other biomarkers [19].…”

Independent associations of thyroid-related hormones with hepatic steatosis and insulin resistance in euthyroid overweight/obese Chinese adults

“…In the current study, NAFLD was evaluated by CAP, which was a newly developed non-invasive and quantitative evaluation method and has been widely used as a first-line assessment for screening fatty liver [22]. In addition, CAP values were closely associated with metabolic syndrome (MetS) and its components including obesity, hypertriglyceridemia, hyperglycemia and hypertension [32]. FLI, as is a simple, accurate and non-invasive approach, has also shown a good capability for discriminating individuals with NAFLD from those without it in a populationbased study with 7-year follow up [33].…”

Quantification of Liver Fat by MRI-PDFF Imaging in Patients with Suspected Non-alcoholic Fatty Liver Disease and Its Correlation with Metabolic Syndrome, Liver Function Test and Ultrasonography

“…These findings are consistent with the previous studies, which have shown that liver fat quantification measured by CAP values is closely associated with MetS and its components. 24,25 MRI-PDFF performed in adolescent girls and young women also showed that a low threshold on MRI-PDFF is predictive of MetS. 26 Abnormal LFTs have been used as a noninvasive marker of NASH.…”