The correlation between EDSS and cognitive impairment in MS patients. Assessment of a Brazilian population using a BICAMS version

Caneda, Marco A. G. de; Vecino, Maria Cecília Aragon de

doi:10.1590/0004-282x20160151

Cited by 15 publications

(12 citation statements)

References 28 publications

(79 reference statements)

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“…Unfortunately, detailed neuropsychological assessments were not available in this cohort. However, clinical disability, as measured with EDSS, has been linked to cognitive decline in a number of studies ( Caneda and Vecino, 2016 , Deloire et al, 2010 , Moccia et al, 2016 , Uher et al, 2017 ), lending further credence to our results.…”

Section: Discussionsupporting

confidence: 85%

Gray matter atrophy patterns in multiple sclerosis: A 10-year source-based morphometry study

Bergsland

Horáková

Dwyer

et al. 2018

NeuroImage: Clinical

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ObjectivesTo investigate spatial patterns of gray matter (GM) atrophy and their association with disability progression in patients with early relapsing-remitting multiple sclerosis (MS) in a longitudinal setting.MethodsBrain MRI and clinical neurological assessments were obtained in 152 MS patients at baseline and after 10 years of follow-up. Patients were classified into those with confirmed disability progression (CDP) (n = 85) and those without CDP (n = 67) at the end of the study. An optimized, longitudinal source-based morphometry (SBM) pipeline, which utilizes independent component analysis, was used to identify eight spatial patterns of common GM volume co-variation in a data-driven manner. GM volume at baseline and rates of change were compared between patients with CDP and those without CDP.ResultsThe identified patterns generally included structurally or functionally related GM regions. No significant differences were detected at baseline GM volume between the sub-groups. Over the follow-up, patients with CDP experienced a significantly greater rate of GM atrophy within two of the eight patterns, after correction for multiple comparisons (corrected p-values of 0.001 and 0.007). The patterns of GM atrophy associated with the development of CDP included areas involved in motor functioning and cognitive domains such as learning and memory.ConclusionSBM analysis offers a novel way to study the temporal evolution of regional GM atrophy. Over 10 years of follow-up, disability progression in MS is related to GM atrophy in areas associated with motor and cognitive functioning.

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Section: Discussionsupporting

confidence: 85%

Gray matter atrophy patterns in multiple sclerosis: A 10-year source-based morphometry study

Bergsland

Horáková

Dwyer

et al. 2018

NeuroImage: Clinical

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“…Our second hypothesis to explain the worse performance of the MSNQ in the higher EDSS ranges related to the overestimation of cognitive functioning, resulting in lower MSNQ scores, being associated with more severe cognitive impairment, 22 more frequently seen in the higher EDSS ranges. 22,23 The inverse correlation between MSNQ and EDSS scores observed in the high EDSS group only supports this explanation. In case of an accurate patient-reported assessment of cognition, we would have expected a positive correlation due to the presumably higher prevalence of CI in higher EDSS ranges.…”

Section: Discussionmentioning

confidence: 94%

“…Furthermore, when assessing discrepancies between self- and informant-reported cognitive performance with the MSNQ, overestimators performed worse on neuropsychological test batteries than underestimators and accurate estimators. 21 Since higher EDSS scores have been associated with an increased risk of objective cognitive decline, 22,23 overestimating cognitive performance when completing the patient-report MSNQ, resulting in lower MSNQ scores, can be expected to occur in a higher proportion of patients with moderate to severe disability.…”

Section: Introductionmentioning

confidence: 99%

Correlates of patient-reported cognitive performance with regard to disability

Laethem

Cock

Schependom

et al. 2021

Preprint

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Background: The inconsistent association of patient−reported Multiple Sclerosis Neuropsychological Questionnaire (MSNQ) scores with performance−based cognitive tests in MS could be related to the degree of disability, due to certain MSNQ−questions assuming some self−dependence and intact instrumental ADLs. Objectives: To test whether the relation between subjective and objective cognitive performance could be moderated by physical disability as measured by the Expanded Disability Status Scale (EDSS), we assessed the correlation between MSNQ and Symbol Digit Modalities Test (SDMT) scores in different EDSS groups. Methods: From 288 MS patients who completed the patient−report MSNQ and a two−question screening tool for depression, we also collected SDMT and EDSS scores. We analysed correlations in the total group and three EDSS subgroups: Low 0.0 − 3.0, Medium 3.5 − 6.0 and High 6.5 − 9.5. Results: We found a significant and negative correlation between patient−reported MSNQ scores and SDMT scores in the low EDSS (r = −.225, p = .044), but not in the medium and high EDSS groups, and significant positive correlations between MSNQ and depression in all subgroups. Conclusions: Our data suggest that the patient−report MSNQ has potential as a measure of cognition in patients with low EDSS-scores but not in the medium and high EDSS ranges.

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“…The subjects in the MS Group were selected from the sample of a previously performed study, following approval of the local research ethics committee. 7 …”

Section: Methodsmentioning

confidence: 99%

“… 5 The prevalence of Cognitive Impairment (CI) in MS ranges widely, from 40 to 70%, 3 , 6 with similar rates found in Brazil. 7 , 8…”

mentioning

confidence: 99%

The Reliability of the Brief Visuospatial Memory Test - Revised in Brazilian multiple sclerosis patients

Caneda

Cuervo

Marinho

et al. 2018

Dement. neuropsychol.

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Cognitive Impairment (CI) is a common and distressing problem in Multiple Sclerosis (MS). Its identification is complicated and sometimes omitted in the routine evaluation by neurologists. The BICAMS (Brief International Cognitive Assessment for Multiple Sclerosis) is a promising tool to overcome this difficulty. However, there is some concern regarding the subjectivity in scoring of the BVMT-R (Brief Visuospatial Memory Test - Revised), one of its components.Objective:To evaluate the reliability of the BVMT-R in a sample of Brazilian MS patients, with the measure being administered and scored by neurologists.Methods:BICAMS was applied to seventy subjects comprising forty patients diagnosed with MS and thirty healthy controls. In the MS patients group, the coefficients of agreement between three different raters, using the same protocols, and the internal consistency of the BVMT-R were assessed. Also, the coefficients of correlation of the BVMT-R with the other tests of the BICAMS, CVLT II (California Verbal Learning Test II) and SDMT (Symbol Digit Modalities Test), and their respective effect sizes were calculated.Results:the BVMT-R presented a moderate inter-rater coefficient of agreement (k=0.62), an excellent Intraclass Correlation Coefficient (ICC=0.85), and high internal consistency (α=0.92). The correlation between the BVMT-R and CVLT II was moderate (ρ=0.36; p<0.025), but strong with the SDMT (ρ=0.60; p<0.01), with a large effect size.Conclusion:The BVMT-R is a reliable instrument for assessing CI in patients with MS, having a significant association with information processing speed, an aspect which should be considered when evaluating its score.

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The correlation between EDSS and cognitive impairment in MS patients. Assessment of a Brazilian population using a BICAMS version

Cited by 15 publications

References 28 publications

Gray matter atrophy patterns in multiple sclerosis: A 10-year source-based morphometry study

Gray matter atrophy patterns in multiple sclerosis: A 10-year source-based morphometry study

Correlates of patient-reported cognitive performance with regard to disability

The Reliability of the Brief Visuospatial Memory Test - Revised in Brazilian multiple sclerosis patients

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