The Correlation between Hemostatic Parameters and Mortality Rate in Patients with Non-Small Cell Lung Cancer

Abstract

The increasing level of hemostatic parameters and tumor markers were associated with cancer progression and poor prognosis, particularly in NSCLC. The objective of this study is to determine whether there was a correlation between hemostatic parameters and mortality rate in patients with NSCLC. This was a prospective analytical study with a pretest-posttest design which included 41 patients with diagnosis of NSCLC. Plasma levels of PT, APTT, TT, D-dimer, and fibrinogen were measured before initiation of chemotherapy and remeasured after 4 cycles or 6 cycles of chemotherapy, based on the clinical condition of patients. Then, patients were followed up for 1 year to evaluate the mortality rate. The majority of subjects were male (85.4%) with adenocarcinoma (75.6%). There was no significant difference in mean between adenocarcinoma and squamous cell carcinoma (P>0.05). Most patients died after one month of follow up (61%). The parameters which could predict high mortality rate in NSCLC were prolonged PT and the increased of D-dimer with RR>1, although they had not significant in statistical analysis (P>0.05). There is no correlation between hemostatic parameters and mortality rate in patients with NSCLC.

The prognostic role of coagulation markers in the progression and metastasis of laryngeal squamous cell carcinoma

“…Fib was high in patients with advanced and poorly differentiated LSCC. Accordingly, it was reported that Fib is elevated in various malignancies, including colorectal, lung, breast, and gastric [26, 37,38]. Moreover, we found that Fib increased more signi cantly in LSCC patients with poor differentiation, lymph node metastasis, neurovascular invasion, and advanced LSCC.…”

Development and validation of a nomogram model for lung cancer based on radiomics artificial intelligence score and clinical blood test data

“…cells to release procoagulant products (19). This can be also one of the potential targets for cancer detection in the future.…”

“…Moreover, APTT is one of the routine indexes of hemostatic examination for surgical patients, the optimal cutoff value for APTT time was 34 S with a sensitivity of 60.6% and a specificity of 72.12% ( 18 ). Tumor cell products presented on their surface or substances secreted in the microenvironment may either directly trigger clotting system activation or indirectly trigger it by stimulating extravascular host cells to release procoagulant products ( 19 ). This can be also one of the potential targets for cancer detection in the future.…”

Hypercoagulability State Combined with Post-Treatment Hypofibrinolysis in Invasive Breast Cancer: A Seven-Year Follow-Up Evaluating Disease-Free and Overall Survival

“…The association between malignancy and disturbances in the haemostasis balance has been studied for almost two centuries [ 18 ]. In recent years, a large number of researchers have reported a significant role of both coagulation and fibrinolytic parameters in the pathogenesis of several cancers as prognostic and predictive indicators of survival and future clinical outcomes [ 19 ]. There is much evidence indicating that components of the haemostatic system contribute to the fundamental aspects of tumour biology, such as angiogenesis, metastasis, cancer progression and modulation of immune responses [ 20 , 21 ].…”