The Correlation between Infants’ Congenital Heart Defects and Maternal Folic Acid Supplementation

Hassan, Alruwaili Fahad Saleh; Howsawi, Basmeh Mohammed I; Awwas, Muayad Youssof Al; Alzein, Zainab Hassan; Alanazi, Farhan Musafiq; Faqehi, Haya; Mugharbal, Ehab Osama; Alrehaili, Muath Ayidh; Alshehri, Khalid Ahmed Abdullah; Buzeid, Reem; Alharbi, Khalid Jazi; Alrzoq, Musab Abdulrahman

doi:10.12816/0043981

Cited by 4 publications

(3 citation statements)

References 3 publications

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“…Cousin marriage can cause congenital heart defects (18). Congenital cardiovascular malformations are common in these associations and affect 2.4 to 8.0 in 1000 infants (19). In our study, prenatal cardiac findings were found in 15 fetuses.…”

Section: Discussionsupporting

confidence: 50%

Analysis of perinatal outcomes of pregnancies from consanguineous marriages in a tertiary hospital in Bursa, Turkey

Karaşin

Kazancı

PAKAY>

et al. 2023

Journal of Health Sciences and Medicine

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Aim: In this article, we aimed to contribute to the outcomes of the consanguineous marriage literature by analyzing fetal results in this population. Material and Method: We included 185 patients in this retrospective research. Demographic, clinical, ultrasonographic and delivery data were received from electronic patient records. Also, we recorded the postnatal results, and findings of the infants. By combining all the data, we reported a descriptive analysis of the results of our consanguineous marriage cases with perinatology follow-up. Results: We had 231 pregnant women in the study, and their mean age was 28.9 years. 117 (50.6%) of the pregnant women had first-degree, and 114 (50.4%) had second-degree consanguineous marriages. Fetal findings were evaluated as usual in 157 (68%) of the pregnant in the ultrasonographic scans performed between prenatal 20-24 weeks of gestation. When we look at the first postnatal examinations of the babies, no abnormal findings were in 134 babies (58.8%). Twenty-two infants (9.6%) were followed up in the neonatal intensive care unit with the diagnosis of transient tachypnea of the newborn, and phototherapy was required in 14 infants (6.1%) due to hyperbilirubinemia. The number of cases requiring surgical intervention after delivery or with significant life-threatening anomalies included 56 findings in 32 infants. There were spina bifida cases in 8 infants and hydrocephalus in 9 infants. Conclusion: There was an increased level of congenital anomalies associated with consanguineous marriages. Health care centers should educate individuals regarding the negative role of cousin marriages leading to abnormalities in children.

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Section: Discussionsupporting

confidence: 50%

Analysis of perinatal outcomes of pregnancies from consanguineous marriages in a tertiary hospital in Bursa, Turkey

Karaşin

Kazancı

PAKAY>

et al. 2023

Journal of Health Sciences and Medicine

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“…Regarding use of folic acid which is supposed to play role in prevention of CHD was taken by only 20% of mothers during pregnancy which was found significant with p value <0.01 Metaanalysis by Hassan et al and Feng reports intake of folic acid by mothers significantly decreased risk of CHDs. Another study reports marked decline in various CHDs including ventricular septal defect, tetralogy of Fallot, transposition of great arteries and atrial septal defect in infants born to mothers who had taken high doses of folic acid during the critical period of CHD development [14,15,16].…”

Section: Resultsmentioning

confidence: 99%

Is Decline Possible in Congenital Heart Defects by Adjusting Avoidable Risk Factors?

Goswami

Sheikh

Rajpar

et al. 2022

JPRI

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Introduction: Congenital heart defects (CHD) are the leading causes of birth defects-associated morbidity and mortality with incidence variable with geographic locale, race, family history and gender of the baby. Material and Methods: This descriptive study was conducted on 96 infants after ethical approval; infants of both genders with diagnosis of CHDs were registered. After complete history and physical examination type of anomaly observed was confirmed by echocardiography. Data was analyzed by using SPSS 21.0 Chi square test was applied for comparison of categorical variables, p<0.05 was considered significant. Results: During study period total 96 patients were examined. Significant association of various types of CHDs with cousin marriage, lack of folic acid intake and positive family history were observed on Pearson chi-square statically significant p-value (<0.01) was observed shown in tables. Conclusion: Further studies on modifiable risk factors on big sample size will be very helpful in decreasing the load of CHDs, and patients can also be facilitated with early diagnosis and management.

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“…Cousin marriage may also cause inborn heart disorders. Inborn cardiovascular malformations are widespread, affecting 2.4 to 8.0 per 1000 infants [7]. Imperfect formation of an embryo or abnormal growth may cause formational deformities in fetus referred as birth defects.…”

Section: Introductionmentioning

confidence: 99%

A Study of Association of Consanguineous Marriages with Congenital Anomalies Among the People Around RHTC of a Medical College in Karimnagar

Akhil,

Thirupathi,

Agrawal

2024

ijmsdr

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Introduction: Congenital anomalies are a major health problem all over the world; especially it is important cause of deaths and birth defects, chronic illness and disability in infants. The major cause of this is consanguineous marriages. Generation of cousin marriages have significant association with congenital anomalies Objective: To find out the association of consanguineous marriages with congenital anomalies present at the time of birth Methods: A cross sectional study was conducted in 2022: The adult individuals aged between 19 to 55 years, with and without cousin marriage of both genders were consecutively enrolled. Participants were assessed through pre-tested questionnaire, with prior written informed consent. Unwilling married individuals and individuals from other hospitals were not selected Results: According to results there was a significant association between generation of cousin marriages with congenital anomalies present at the time of birth, as p value was 0.002 Conclusions: Study concluded that the generation of cousin marriages has significant association with congenital anomalies present at the time of birth and due to cousin marriage 59% of the couples had congenital abnormalities in their children and 85% had genetic disorders.

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The Correlation between Infants’ Congenital Heart Defects and Maternal Folic Acid Supplementation

Cited by 4 publications

References 3 publications

Analysis of perinatal outcomes of pregnancies from consanguineous marriages in a tertiary hospital in Bursa, Turkey

Analysis of perinatal outcomes of pregnancies from consanguineous marriages in a tertiary hospital in Bursa, Turkey

Is Decline Possible in Congenital Heart Defects by Adjusting Avoidable Risk Factors?

A Study of Association of Consanguineous Marriages with Congenital Anomalies Among the People Around RHTC of a Medical College in Karimnagar

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