The correlation between pancreatic dysfunction markers and selected indices of periodontitis

Abstract

Background. Periodontitis is a major risk factor of systemic diseases with inflammatory etiology. Numerous studies have established the connection between periodontal condition and diabetes, but there are no reports in the literature on the relationship between periodontitis and other pancreas conditions. The activity of pancreatic enzymes is an important parameter of pancreatic damage, and is also a diagnostic marker of acute and chronic pancreatitis, and the bleeding index determines the periodontitis activity. To date, the periodontal status in both of the above-mentioned conditions has not been examined.

Exploring the Role of Fusobacterium nucleatum in Preterm Birth: A Narrative Review

“…Specifically, it has been investigated the role of the Gram-negative periodontal pathogen FN, an opportunistic pathogen agent having a specific role in pathogenesis of different periodontal conditions [1], [4], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], and it is increasingly recognized as an important agent of PTB. A multitude of studies has identified potential periodontal pathogens that might have a causal role in determining the risk of PTB, evaluating the combined influences of genes with intrinsic and extrinsic environmental factors [45], [46], [47], [48]. These investigations have been pivotal in providing resources for the explanation of the potential impact of microbiome dysbiosis on poor obstetric outcomes [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26].…”

“…Despite the extensive research intended to achieve this objective, there is still a great deal of ambiguity as to the periodontal pathogen sustain this outcome. Whereas the investigation of periodontal pathogen [21] is largely restricted to the research arena, the use of short-read sequencing approach is not well established in clinical periodontology [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56]. Through analyzing the dynamic character of the oral microbial communities and their interactions with the organism, we sought to reveal through which way the association between periodontal disease and general health is understand and interpreted, focus on the relationship between oral microbiome and pregnancy [11].…”

“…FN has been isolated from the amniotic cavity, placenta, chorioamniotic membranes of women delivering prematurely, and fetus. Further, it has been identified in the blood vessels in murine placentas [47]. However, Fusobacterium spp.…”

“…In recent years, substantive attention has been drawn to the relationship between the oral microbiome homeostatic equilibrium disruption and systemic health, demonstrating the negative impacts of this reciprocal biological interplay [41], [43]. In this novel specific context, several researchers have an interest in analyzing the meaning of the potential impact of oral microbiome variations on poor pregnancy outcomes [45], [46], [47]. However, the actual models concerning the biological mechanism underlying the potential relationship between oral microbial community and PTB concern the oral microbiote role, whereby the oral microbiote might be responsible for the colonization of placental membranes and basal plate decidua [11], [12], [13], [14], [15].…”

“…However, the actual models concerning the biological mechanism underlying the potential relationship between oral microbial community and PTB concern the oral microbiote role, whereby the oral microbiote might be responsible for the colonization of placental membranes and basal plate decidua [11], [12], [13], [14], [15]. A multitude of studies has identified potential periodontal pathogens that might have a causal role in determining the risk of PTB, evaluating the combined influences of genes with intrinsic and extrinsic environmental factor [46], [47], [48], [49]. The balance of the oral microbiome is conditioned on the biological resources, environmental modifications, and the development of sui generis species variety.…”