The correlation between plasma cytokine levels in jaundice-free children with biliary atresia

Jian, Zhihong; Wang, Li-Ching; Lin, Chou-Ching K.; Wang, Jiaan-Der

doi:10.1007/s12519-015-0023-5

Cited by 12 publications

(9 citation statements)

References 31 publications

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“…Taken together, these results suggest that, in children with ESLD, the TGF‐β1 blood level is negatively related to the cholestatic liver diseases and positively related to the fibrosis of mild severity. This suggestion is consistent with data from Jian et al, who showed that TGF‐β1 plasma level in jaundice‐free children with BA (after Kasai procedure) is higher than it is in healthy controls. However, as some of our data are received from small samples further studies are required to draw more certain conclusions about the relationship of TGF‐β1 with cholestasis and fibrosis.…”

Section: Discussionsupporting

confidence: 92%

Transforming growth factor beta 1 levels in the blood of pediatric liver recipients: Clinical and biochemical correlations

Курабекова

Цирульникова

Pashkova

et al. 2020

Pediatric Transplantation

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TGF‐β1 is a cytokine with profibrogenic and immunosuppressive activities, which suggest the clinical significance of TGF‐β1 for the assessment of graft function after LT. We analyzed the dynamics of TGF‐β1 levels in the blood after LDLT in 135 pediatric liver recipients and examined the relationship between the cytokine levels and the laboratory and clinical variables. We found that TGF‐β1 levels in the blood of patients with ESLD were lower than that in healthy children of the same age, P = .001. Moreover, blood levels of TGF‐β1 were associated with liver disease etiology (r = .23) and hepatic fibrosis severity (r = .33). Before LDLT, TGF‐β1 levels were significantly higher in children with good outcomes than in recipients who developed graft dysfunction early in the post‐transplant period, P = .047. One month after LDLT, TGF‐β1 levels in blood plasma increased in pediatric recipients, P = .002. Cytokine levels were significantly correlated with gender (r = .21) and HLA (r = −.24) mismatches, as well as with TAC dosage (r = −.32) later in the post‐transplant period. One year after LDLT, TGF‐β1 plasma levels were higher (P = .01) than those before LDLT and did not correlate with most of the investigated biochemical and clinical variables. Conclusion: Blood levels of TGF‐β1 are associated with hepatic fibrosis severity, graft dysfunction development, and TAC dosage and can be regarded as a potential prognostic biomarker for the assessment of graft function and the optimization of immunosuppressant dosage in pediatric recipients after LDLT.

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Section: Discussionsupporting

confidence: 92%

Transforming growth factor beta 1 levels in the blood of pediatric liver recipients: Clinical and biochemical correlations

Курабекова

Цирульникова

Pashkova

et al. 2020

Pediatric Transplantation

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“…In a report by Narayanaswamy et al, 23 21 patients with biliary atresia showed a marked increase in the levels of Th1 (IFN-g and IL-2) and Th2 (IL-4) cytokines 6 months after the Kasai operation, compared with at the time of operation. According to our previous report, 12 increased IFN-g levels were found in jaundice-free biliary atresia patients with impaired liver function and portal hypertension. ASTto-platelet ratio index (APRI) is a simple tool used to assess the degree of liver fibrosis in children with biliary atresia following Kasai surgery.…”

Section: Discussionmentioning

confidence: 70%

“…According to previous studies, various cytokines released by CD4þ Th cells may contribute to biliary atresia disease presentation and progression. 11,12 We can divide CD4þ Th cells into four main subsets, including Th1, Th2, Th3, and Th17 cells. 22 Th1 cells activate macrophages by IFN-g and IL-2, while Th2 cells are responsible for humoral immune response by IL-4 and IL-10.…”

Section: Discussionmentioning

confidence: 99%

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Factors Determining Bone Mineral Density in Patients with Biliary Atresia after a Successful Kasai Operation

Chen

Wang

Chou

et al. 2017

Pediatrics & Neonatology

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“…It seems clear that a better understanding of the molecular mechanisms behind BA pathology is of critical importance to the discovery of a potential indicator for predicting disease progression. Although the exact cause of BA remains a matter of debate, several factors, particularly molecule-mediated inflammation, have been reportedly involved in its pathogenesis [11-13]. In the present study, we investigated circulating GPC3 levels obtained from BA patients compared to healthy controls and associations between circulating levels of GPC3 and clinical parameters of hepatic dysfunction in BA patients.…”

Section: Discussionmentioning

confidence: 97%

Increased serum glypican-3 is associated with liver stiffness and hepatic dysfunction in children with biliary atresia

Sirisomboonlarp

Udomsinprasert

McConachie

et al. 2019

ceh

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Aim of the studyBiliary atresia (BA) is an uncommon disorder of the liver and bile ducts affecting infants and is characterized by progressive fibrosclerosing obstruction of the extrahepatic biliary tree leading to end-stage liver failure. The purpose of this study was to determine serum glypican-3 (GPC3) levels and liver stiffness in children with BA and the correlation of glypican-3 with clinical parameters.Material and methodsSeventy-five post-Kasai BA patients and 28 healthy age-matched controls were registered. Serum GPC3 levels were examined by enzyme-linked immunosorbent assay. Liver stiffness measurement was analyzed by transient elastography.ResultsBA patients had significantly greater serum GPC3 and liver stiffness values than controls (p < 0.001). Serum GPC3 and liver stiffness values were significantly higher in jaundiced BA patients than in non-jaundiced BA patients (p < 0.001). Additionally, serum glypican-3 was associated with liver stiffness and serum total bilirubin (p < 0.001, respectively).ConclusionsElevated serum GPC3 levels were associated with hepatic dysfunction and the severity of BA. As a result, serum GPC3 and liver stiffness might serve as biomarkers reflecting the deterioration of hepatic function and the outcome in post-Kasai BA.

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The correlation between plasma cytokine levels in jaundice-free children with biliary atresia

Abstract: IFN-γ and IL-10 are likely to be involved in the disease progression in BA. Besides, TGF-β1 is found to be a suppression marker associated with SDF-1α levels and reduced production of TGF-β1 may be associated with the disease progression.

Cited by 12 publications

References 31 publications

Transforming growth factor beta 1 levels in the blood of pediatric liver recipients: Clinical and biochemical correlations

Transforming growth factor beta 1 levels in the blood of pediatric liver recipients: Clinical and biochemical correlations

Factors Determining Bone Mineral Density in Patients with Biliary Atresia after a Successful Kasai Operation

Increased serum glypican-3 is associated with liver stiffness and hepatic dysfunction in children with biliary atresia

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