The correlation between plasma total homocysteine level and gestational diabetes mellitus in a Chinese Han population

Deng, Mengyao; Zhou, Jia; Tang, Zhao; Xiang, Jun; Jing, Y. P.; Peng, Yushuang; Di, Lihua; Zhai, Xiaobing; Yang, Mei; Du, Yukai

doi:10.1038/s41598-020-75797-w

Cited by 13 publications

(9 citation statements)

References 28 publications

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“…Interestingly, neither study observed differences in serum vitamin B12 nor folate. Several studies which did not stratify for glucose intolerance have also observed increased serum homocysteine in women with GDM-complicated pregnancies compared to non-GDM pregnancies [ 122 , 123 , 124 , 125 , 126 ].…”

Section: Association Between One-carbon Metabolism Players and Gdmmentioning

confidence: 99%

High Folate, Perturbed One-Carbon Metabolism and Gestational Diabetes Mellitus

et al. 2022

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Folate is a dietary micronutrient essential to one-carbon metabolism. The World Health Organisation recommends folic acid (FA) supplementation pre-conception and in early pregnancy to reduce the risk of fetal neural tube defects (NTDs). Subsequently, many countries (~92) have mandatory FA fortification policies, as well as recommendations for periconceptional FA supplementation. Mandatory fortification initiatives have been largely successful in reducing the incidence of NTDs. However, humans have limited capacity to incorporate FA into the one-carbon metabolic pathway, resulting in the increasingly ubiquitous presence of circulating unmetabolised folic acid (uFA). Excess FA intake has emerged as a risk factor in gestational diabetes mellitus (GDM). Several other one-carbon metabolism components (vitamin B12, homocysteine and choline-derived betaine) are also closely entwined with GDM risk, suggesting a role for one-carbon metabolism in GDM pathogenesis. There is growing evidence from in vitro and animal studies suggesting a role for excess FA in dysregulation of one-carbon metabolism. Specifically, high levels of FA reduce methylenetetrahydrofolate reductase (MTHFR) activity, dysregulate the balance of thymidylate synthase (TS) and methionine synthase (MTR) activity, and elevate homocysteine. High homocysteine is associated with increased oxidative stress and trophoblast apoptosis and reduced human chorionic gonadotrophin (hCG) secretion and pancreatic β-cell function. While the relationship between high FA, perturbed one-carbon metabolism and GDM pathogenesis is not yet fully understood, here we summarise the current state of knowledge. Given rising rates of GDM, now estimated to be 14% globally, and widespread FA food fortification, further research is urgently needed to elucidate the mechanisms which underpin GDM pathogenesis.

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Section: Association Between One-carbon Metabolism Players and Gdmmentioning

confidence: 99%

High Folate, Perturbed One-Carbon Metabolism and Gestational Diabetes Mellitus

et al. 2022

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“…The diagnosis of GDM was based on the criteria of International Association of Diabetes and Pregnancy Study Groups. The pregnancy was judged as GDM with blood glucose levels at any time over the following criterion: fasting 5.1 mmol/L, 1 h 10.0 mmol/L and 2 h 8.5 mmol/L 10 . Finally, 120 GDM patients and 108 gestational week‐matched pregnancies with NGT were enrolled in our study.…”

Section: Methodsmentioning

confidence: 99%

Interleukin‐33 and its receptor soluble suppression of tumorigenicity 2 in the diagnosis of gestational diabetes mellitus

Fan

Kang

et al. 2021

Int J Clinical Practice

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Background Gestational diabetes mellitus (GDM) is the most common pregnancy‐related disease that increases the risk of metabolic disorders for the pregnancies and their offspring. GDM could be effectively prevented by early diagnosis and timely treatment. Methods 120 patients with GDM and 108 gestational week‐matched pregnancies with normal glucose tolerance (NGT) were enrolled in our study. Their blood samples were collected, and demographic characteristics were analysed. Results Compared to NGT pregnancies, patients with GDM had increased the secretions of interleukin (IL)‐33, soluble suppression of tumorigenicity 2 (sST2), IL‐6 and tumour necrosis factor‐α (TNF‐α) in their plasma with elevated homeostatic model assessment (HOMA). Moreover, IL‐33/sST2 was positively correlated with HOMA, IL‐6 and TNF‐α levels in the plasma of patients with GDM respectively. Conclusion IL‐33/sST2 might serve as a novel potential biomarker for early diagnosis of GDM.

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Section: Hct and Gdmmentioning

confidence: 99%

“…A case-control research was conducted in China; it contained 350 GDM women and 346 normal glucose tolerance (NGT) pregnant females [ 122 ]. Patients with GDM exhibited an elevated plasma tHct expression than NGT females ( P < 0.05) [ 122 ]. The GDM risk was 1.79 times higher in patients with increased tHct (≥7.29 μ mol/L) relative to females with lower tHct expression (<5.75 μ mol/L) [ 122 ].…”

Section: Hct and Gdmmentioning

confidence: 99%

“…Patients with GDM exhibited an elevated plasma tHct expression than NGT females ( P < 0.05) [ 122 ]. The GDM risk was 1.79 times higher in patients with increased tHct (≥7.29 μ mol/L) relative to females with lower tHct expression (<5.75 μ mol/L) [ 122 ]. The association between Hct and GDM history has also been analyzed in an empirical study [ 123 ].…”

Section: Hct and Gdmmentioning

confidence: 99%

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A Novel Review of Homocysteine and Pregnancy Complications

Dai

Fei

et al. 2021

BioMed Research International

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Homocysteine (Hct) is a substance produced in the metabolism of methionine. It is an essential type of amino acid gained from the daily diet. Methylenetetrahydrofolate reductase (MTHFR) gene mutation is related to elevated total homocysteine (tHct) expressions, in particular, among women with low folate intake. Hyperhomocysteinemia (HHct) is caused by numerous factors, such as genetic defects, lack of folic acid, vitamin B6 and B12 deficiency, hypothyroidism, drugs, aging, and renal dysfunction. Increased Hct in peripheral blood may lead to vascular illnesses, coronary artery dysfunction, atherosclerotic changes, and embolic diseases. Compared to nonpregnant women, the Hct level is lower in normal pregnancies. Recent studies have reported that HHct was associated with numerous pregnancy complications, including recurrent pregnancy loss (RPL), preeclampsia (PE), preterm delivery, placental abruption, fetal growth restriction (FGR), and gestational diabetes mellitus (GDM). Besides, it was discovered that neonatal birth weight and maternal Hct levels were negatively correlated. However, a number of these findings lack consistency. In this review, we summarized the metabolic process of Hct in the human body, the levels of Hct in different stages of normal pregnancy reported in previous studies, and the relationship between Hct and pregnancy complications. The work done is helpful for obstetricians to improve the likelihood of a positive outcome during pregnancy complications. Reducing the Hct level with a high dosage of folic acid supplements during the next pregnancy could be helpful for females who have suffered pregnancy complications due to HHct.

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The correlation between plasma total homocysteine level and gestational diabetes mellitus in a Chinese Han population

Cited by 13 publications

References 28 publications

High Folate, Perturbed One-Carbon Metabolism and Gestational Diabetes Mellitus

High Folate, Perturbed One-Carbon Metabolism and Gestational Diabetes Mellitus

Interleukin‐33 and its receptor soluble suppression of tumorigenicity 2 in the diagnosis of gestational diabetes mellitus

A Novel Review of Homocysteine and Pregnancy Complications

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