The correlation between <scp>SNP</scp>s within the gene of adrenergic receptor and neuropeptide Y and risk of cervical vertigo

Han, Jianlong; Zuo, Jianjun; Zhu, Dengsong; Gao, Chunzheng

doi:10.1002/jcla.22366

Cited by 5 publications

(5 citation statements)

References 35 publications

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“…To the best of our knowledge, Runx2 is an important early transcription factor involved in the expression of osteoblast-specific genes, and the differentiation of mesenchymal stem cells into osteoblasts ( 19 ). In addition, Runx2 is hypothesized to serve a primary role in the terminal differentiation of osteoblasts ( 20 ).…”

Section: Resultsmentioning

confidence: 99%

“…nPY is a neurotransmitter that has dual functions in the regulation of energy consumption and bone mass (11). a previous study determined that SnPs within nPY and neuraminidase (na) were closely associated with the susceptibility and prognosis of patients with cervical vertigo (19). Therefore, nPY and na could be used as diagnostic markers and therapeutic targets for cervical vertigo (19).…”

Section: Discussionmentioning

confidence: 99%

“…a previous study determined that SnPs within nPY and neuraminidase (na) were closely associated with the susceptibility and prognosis of patients with cervical vertigo (19). Therefore, nPY and na could be used as diagnostic markers and therapeutic targets for cervical vertigo (19). igwe et al (15) revealed that mouse calvarial osteoblasts fostered in the presence of nPY decreased the expression of differentiation-related markers, including ocn, BSP and dentin matrix acidic phosphoprotein 1 (dMP1), and also reduced the extent of mineralization.…”

Section: Discussionmentioning

confidence: 99%

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Neuropeptide�Y upregulates Runx2 and osterix and enhances osteogenesis in mouse MC3T3‑E1 cells via an autocrine mechanism

Zhang

Zhou

et al. 2020

Mol Med Rep

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The neuropeptide Y (nPY) system is considered one of the primary neural signaling pathways. nPY, produced by osteoblasts and other peripheral tissues, is known to inhibit biological functions of osteoblasts. However, until recently, little was known of the autocrine mechanism by which nPY is regulated. To investigate this mechanism, overexpression plasmids and small interfering rna (sirna) targeting nPY were transfected into the Mc3T3-e1 cell line to observe its effects on osteogenesis. nPY overexpression was found to markedly enhance the osteogenic ability of Mc3T3-e1 cells by an autocrine mechanism, coincident with the upregulation of osterix and runt-related transcription factor 2 (runx2). Furthermore, nPY increased the activities of alkaline phosphatase (alP) and osteocalcin (ocn) by upregulating their osteoblastic expression in vitro (as well as that of osterix and runx2). Following transfection with nPY-sirna, the osteoblastic ability of MC3T3-E1 cells was markedly decreased, and NPY deficiency inhibited the protein expression of osterix, runx2, ocn and alP in primary osteoblasts. collectively, these results indicated that nPY played an important role in osteoblast differentiation by regulating the osterix and runx2 pathways.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Neuropeptide�Y upregulates Runx2 and osterix and enhances osteogenesis in mouse MC3T3‑E1 cells via an autocrine mechanism

Zhang

Zhou

et al. 2020

Mol Med Rep

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“…The prevalence of etiology collected and 95% CI in pediatric patients were calculated for each study, respectively, with heterogeneity. A total of 37 kinds of etiological diagnoses were categorized as peripheral vertigo disorders, central vertigo disorders, psychogenic vertigo, or other systemic diseases (30,31). In addition, some vertigo symptoms or balance problems that could not be diagnosed accurately were categorized as unclassified vertigo and excluded from data analysis.…”

Section: Resultsmentioning

confidence: 99%

“…Jahn (33) reported that the causes were classified as peripheral vestibular disorders, central vestibular disorders, and non-vestibular dizziness. We separate psychogenic vertigo and other systemic vertigo into two individual groups apart from peripheral vertigo and central vertigo, since more evidence was provided that mental problems and systemic disease interacted closely with vestibular disorders in children (31,34).…”

Section: Discussionmentioning

confidence: 99%

Etiological classification and management of dizziness in children: A systematic review and meta-analysis

Zhang

Zhu²,

Shen³

et al. 2023

Front. Neurol.

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BackgroundDizziness in children, which could not be diagnosed at an early stage in the past, is becoming increasingly clear to a large extent. However, the recognition of the diagnosis and management remains discrepant and controversial due to their complicated and varied etiology. Central and peripheral vestibular disorders, psychogenic and systemic diseases, and genetic pathogeny constitute childhood etiological entities. Further understanding of the etiology and the prevalence of vertigo disorders is of crucial importance and benefit in the diagnosis and management of pediatric patients.MethodsThis systematic review and meta-analysis were conducted by systematically searching Embase, PubMed, the Cochrane Library, CNIK, the Chinese Wan-Fang database, CBM, the Chinese VIP database, and the Web of Science for literature on childhood vertigo disorders published up to May 2022. The literature was evaluated under strict screening and diagnostic criteria. Their quality was assessed using the Agency for Healthcare and Research Quality (AHRQ) standards. The test for homogeneity was conducted to determine the fixed effects model or random-effect model employed.ResultsTwenty-three retrospective cross-sectional studies involving 7,647 children with vertigo disorders were finally included, with an AHRQ score >4 (high or moderate quality). Our results demonstrated that peripheral vertigo (52.20%, 95% CI: 42.9–61.4%) was more common in children than central vertigo (28.7%, 95% CI: 20.8–37.4%), psychogenic vertigo (7.0%, 95% CI: 4.8–10.0%), and other systemic vertigo (4.7%, 95% CI: 2.6–8.2%). The five most common etiological diagnoses associated with peripheral vertigo included benign paroxysmal vertigo of childhood (BPVC) (19.50%, 95% CI: 13.5–28.3%), sinusitis-related diseases (10.7%, 95% CI: −11.2–32.6%), vestibular or semicircular canal dysfunction (9.20%, 95% CI: 5.7–15.0%), benign paroxysmal positional vertigo (BPPV)(7.20%, 95% CI: 3.9–11.5%), and orthostatic dysregulation (6.8%, 95% CI: 3.4–13.0%). Vestibular migraine (20.3%, 95% CI: 15.4–25.2%) was the most seen etiological diagnosis associated with central vertigo in children. In addition, we found the sex-based difference influenced the outcome of psychogenic vertigo and vestibular migraine, while there was no significant difference in other categories of the etiology. For the management of vertigo, symptomatical management is the first choice for most types of vertigo disorder in pediatrics.ConclusionComplex etiology and non-specific clinical manifestations of vertigo in pediatrics are challenging for their diagnoses. Reliable diagnosis and effective management depend on the close cooperation of multiple disciplines, combined with comprehensive consideration of the alternative characteristics of vertigo in children with growth and development.

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Supplementation with carnosine, a food‐derived bioactive dipeptide, alleviates dexamethasone‐induced oxidative stress and bone impairment via the NRF2 signaling pathway

Li,

Gu,

et al. 2024

J Sci Food Agric

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BACKGROUNDCarnosine, a natural bioactive dipeptide derived from meat muscle, possesses strong antioxidant properties. Dexamethasone, widely employed for treating various inflammatory diseases, raises concerns regarding its detrimental effects on bone health. This study aimed to investigate the protective effects of carnosine against dexamethasone‐induced oxidative stress and bone impairment, along with its underlying mechanisms, utilizing chick embryos and a zebrafish model in vivo, as well as MC3T3‐E1 cells in vitro.RESULTSOur findings revealed that carnosine effectively mitigated bone injury in dexamethasone‐exposed chick embryos, accompanied by reduced oxidative stress. Further investigation demonstrated that carnosine alleviated impaired osteoblastic differentiation in MC3T3‐E1 cells and zebrafish by suppressing the excessive production of reactive oxygen species (ROS) and enhancing the activity of antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GPX). Moreover, mechanistic studies elucidated that carnosine promoted the expression and nuclear translocation of nuclear factor erythroid 2‐related factor 2 (NRF2), thereby facilitating the transcription of its downstream antioxidant response elements, including heme oxyense‐1 (HO‐1), glutamate cysteine ligase modifier (GCLM), and glutamate cysteine ligase catalytic (GCLC) to counteract dexamethasone‐induced oxidative stress.CONCLUSIONOverall, this study underscores the potential therapeutic efficacy of carnosine in mitigating oxidative stress and bone damage induced by dexamethasone exposure, shedding light on its underlying mechanism of action by activating the NRF2 signaling pathway. © 2024 Society of Chemical Industry.

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The correlation between SNPs within the gene of adrenergic receptor and neuropeptide Y and risk of cervical vertigo

Abstract: The SNPs within ADRB2, ADRB1, NPY, and ADRA1A might act as the diagnostic biomarkers and treatment targets for cervical vertigo.

Cited by 5 publications

References 35 publications

Neuropeptide�Y upregulates Runx2 and osterix and enhances osteogenesis in mouse MC3T3‑E1 cells via an autocrine mechanism

Neuropeptide�Y upregulates Runx2 and osterix and enhances osteogenesis in mouse MC3T3‑E1 cells via an autocrine mechanism

Etiological classification and management of dizziness in children: A systematic review and meta-analysis

Supplementation with carnosine, a food‐derived bioactive dipeptide, alleviates dexamethasone‐induced oxidative stress and bone impairment via the NRF2 signaling pathway

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