The Correlation between Size Reduction and the Mechanical Activation of Talc by a Multi-ring Media Mill.

Preparation of nano-and submicron sized particles is a useful method for solubility improvement of poorly watersoluble drugs of oral dosage forms by increasing surface area. In this study, a multi-ring type wet milling system was used to micronize poorly water-soluble drugs, and its performance was investigated. It was confirmed that particle size was easy to control by the operating conditions with adding a little quantity of milling stabilizer. Also, it was considered that a low content of additives is very advantageous in regard to the choice of formulation and characteristics of the final drug products. As a result, the dissolution profiles of ibuprofen and indomethacin which were milled in this study were faster than the non-milled original drugs, and their suspensions were stable for a week without having agglomeration, and the crystallites of the milled drugs were maintained. Also, the usage of the multiring type wet milling system would make easy to determine the scale-up operating conditions from the point of view of the milling mechanism, and a high content of drug substances is advantageous for the manufacturing.

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Micronization of Poorly Water-Soluble Drugs by Multi-Ring Type Wet Milling

Fukuta

Watano

2021

Funtai Kogakkaishi

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乾式ビーズミルの開発とそれによるタルクの粉砕

Shimizu,

Ishikawa,

Saito

2024

Funtai Kogakkaishi

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The Correlation between Size Reduction and the Mechanical Activation of Talc by a Multi-ring Media Mill.

Cited by 2 publications

References 13 publications

Micronization of Poorly Water-Soluble Drugs by Multi-Ring Type Wet Milling

Micronization of Poorly Water-Soluble Drugs by Multi-Ring Type Wet Milling

乾式ビーズミルの開発とそれによるタルクの粉砕

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