The correlation between TG vs remnant lipoproteins in the fasting and postprandial plasma of 23 volunteers

Nakajima, Katsuyuki; Nakano, Takamitsu; Moon, Hyun Duk; Nagamine, Takahiko; Stanhope, Kimber L.; Havel, Peter J.; Warnick, G. Russell

doi:10.1016/j.cca.2009.03.051

Cited by 38 publications

(22 citation statements)

References 22 publications

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“…This observation is in accordance with the previous reports that demonstrated high correlation between plasma VLDL-C and TG concentrations, at least in the healthy subjects [40,41]. Also, the plasma TG concentrations are known to reflect plasma VLDL-C concentrations, regardless of the fasting and postprandial states [40].…”

Section: Discussionsupporting

confidence: 91%

Revisiting the dyslipidemia associated with acute leukemia

Usman

Rashid

Ameer

et al. 2015

Clinica Chimica Acta

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Section: Discussionsupporting

confidence: 91%

Revisiting the dyslipidemia associated with acute leukemia

Usman

Rashid

Ameer

et al. 2015

Clinica Chimica Acta

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“…We reported that non-fasting TG correlated more strongly with remnant lipoproteins than fasting TG [43]. The correlations between postprandial TG and remnant lipoprotein concentrations were significantly more robust when compared with fasting TG vs remnant lipoprotein concentrations.…”

Section: Daily Rhythm Of Plasma Cholesterol Tg and Remnant Lipoprmentioning

confidence: 99%

Postprandial lipoprotein metabolism: VLDL vs chylomicrons

Nakajima¹,

Nakano²,

Tokita³

et al. 2011

Clinica Chimica Acta

Self Cite

134

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Since Zilversmit first proposed postprandial lipemia as the most common risk of cardiovascular disease, chylomicrons (CM) and CM remnants have been thought to be the major lipoproteins which are increased in the postprandial hyperlipidemia. However, it has been shown over the last two decades that the major increase in the postprandial lipoproteins after food intake occurs in the very low density lipoprotein (VLDL) remnants (apoB100 particles), not CM or CM remnants (apoB48 particles). This finding was obtained using the following three analytical methods; isolation of remnant-like lipoprotein particles (RLP) with specific antibodies, separation and detection of lipoprotein subclasses by gel permeation HPLC and determination of apoB48 in fractionated lipoproteins by a specific ELISA. The amount of the apoB48 particles in the postprandial RLP is significantly less than the apoB100 particles, and the particle sizes of apoB48 and apoB100 in RLP are very similar when analyzed by HPLC. Moreover, CM or CM remnants having a large amount of TG were not found in the postprandial RLP. Therefore, the major portion of the TG which is increased in the postprandial state is composed of VLDL remnants, which have been recognized as a significant risk for cardiovascular disease.

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“…We reported that nonfasting TG correlated more strongly with remnant lipoproteins than fasting TG [79]. The correlation between postprandial TG and remnant lipoprotein was significantly more robust when compared with fasting TG versus remnant lipoprotein.…”

Section: Daily Rhythm Of Plasma Tg Apob-48 and Remnant Lipoproteinsmentioning

confidence: 82%

“…Most increased TG after food intake represented increased remnant lipoproteins, $80%. Thus, remnant TG ¼ (postprandial TG À fasting TG) Â 0.8 [79].…”

Section: Daily Rhythm Of Plasma Tg Apob-48 and Remnant Lipoproteinsmentioning

confidence: 99%