The correlation of common carotid arterial diameter with atherosclerosis and diabetic retinopathy in patients with type 2 diabetes mellitus

Miyamoto, Michiaki; Kotani, Kazuhiko; Okada, Kenta; Fujii, Yasutomo; Konno, Kunihiko; Ishibashi, Shun; Taniguchi, Nobuyuki

doi:10.1007/s00592-011-0287-8

Cited by 28 publications

(22 citation statements)

References 32 publications

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“…[30][31][32] CCA-diameter is thought to be an adequate measure for determining the extent of systemic atherosclerosis. 33 Our results may support incidental findings of CAC on panoramic radiographs as a useful marker for systemic atherosclerosis.…”

Section: Discussionsupporting

confidence: 81%

The correlation of carotid artery calcification on panoramic radiographs and determination of carotid artery atherosclerosis with ultrasonography

Lee

Kim

Chung

et al. 2014

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Section: Discussionsupporting

confidence: 81%

The correlation of carotid artery calcification on panoramic radiographs and determination of carotid artery atherosclerosis with ultrasonography

Lee

Kim

Chung

et al. 2014

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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“…In support of this, Krizova et al recently demonstrated that increased intra-vitreous levels of UA may be involved in the pathogenesis and progression of DR [35]. Moreover, micro and macrovascular complications cluster; DR is associated with atherosclerosis [36] and cardiorenal complications remain strongly interrelated in diabetes [37], suggesting possible common underlying risk factors.…”

Section: Discussionmentioning

confidence: 99%

Serum uric acid predicts vascular complications in adults with type 1 diabetes: the coronary artery calcification in type 1 diabetes study

et al. 2014

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Hypothesis Epidemiologic evidence support a link between serum uric acid (SUA) and vascular complications in diabetes, but it remains unclear whether SUA improves the ability of conventional risk factor to predict complications. We hypothesized that SUA at baseline would independently predict the development of vascular complications over 6 years, and that the addition of SUA to American Diabetes Association’s ABC risk factors (HbA1c, BP, LDL-C) would improve vascular complication prediction over 6-years in adults with type 1 diabetes. Methods Study participants (N=652) were 19–56 year old at baseline and re-examined 6-years later. Diabetic nephropathy (DN) was defined as incident albuminuria or rapid GFR decline (>3.3%/year) estimated by the CKD-EPI cystatin C. Diabetic retinopathy (DR) was based on self-reported history, proliferative diabetic retinopathy (PDR) was defined as laser eye therapy; coronary artery calcium (CAC) was measured using electron-beam computed-tomography. Progression of CAC (CACp) was defined as a change in the square-root transformed CAC-volume ≥ 2.5. Predictors of each complication were examined in stepwise logistic regression with subjects with complications at baseline excluded from analyses. C-statistics, integrated-discrimination indices and net-reclassification improvement were utilized for prediction performance analyses. Results SUA independently predicted development of incident albuminuria (OR: 1.8, 95% CI 1.2–2.7), rapid GFR decline (1.9, 1.1–3.3), DR (1.4, 1.1–1.9), PDR (2.1, 1.4–3.0) and CACp (1.5 (1.1–1.9). SUA improved the discrimination and net-classification risk of vascular complications over 6-years. Conclusion SUA independently predicted the development of vascular complications in type 1 diabetes, and also improved the reclassification of vascular complications.

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“…In the present study, the frequency of patients with the plaque ≥2 according to the presence of DR was not significantly different. Miyamoto et al [31] reported that mean CIMT and plaque score were not significantly correlated with DR. Rema et al [18] explained that one of the causes showing discrepancy about association DR with carotid atherosclerosis is by the differences in the ages of the populations studied (Atherosclerosis Risk in Communities study, 51 to 72 years of age; CHS, 69 to 102 years of age; our present study, 31 to 86 years of age). The other potential reasons for the discrepant results may include different sample sizes and population characteristics.…”

Section: Discussionmentioning

confidence: 99%

Association between Cardiac Autonomic Neuropathy, Diabetic Retinopathy and Carotid Atherosclerosis in Patients with Type 2 Diabetes

et al. 2013

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BackgroundIt is not clear whether microangiopathies are associated with subclinical atherosclerosis in type 2 diabetes mellitus (T2DM). We investigated the relation of cardiac autonomic neuropathy (CAN) and other microangiopathies with carotid atherosclerosis in T2DM.MethodsA total of 131 patients with T2DM were stratified by mean carotid intima-media thickness (CIMT) ≥ or <1.0 mm and the number of carotid plaques. CAN was assessed by the five standard cardiovascular reflex tests according to the Ewing's protocol. CAN was defined as the presence of at least two abnormal tests or an autonomic neuropathy points ≥2. Diabetic microangiopathies were assessed.ResultsPatients with CAN comprised 77% of the group with mean CIMT ≥1.0 mm, while they were 29% of the group with CIMT <1.0 mm (P=0.016). Patients with diabetic retinopathy (DR) comprised 68% of the group with CIMT ≥1.0 mm, while they were 28% of the group without CIMT thickening (P=0.003). Patients with CAN comprised 51% of the group with ≥2 carotid plaques, while they were 23% of the group with ≤1 carotid plaque (P=0.014). In multivariable adjusted logistic regression analysis, the patients who presented with CAN showed an odds ratio [OR] of 8.6 (95% confidence interval [CI], 1.6 to 44.8) for CIMT thickening and an OR of 2.9 (95% CI, 1.1 to 7.5) for carotid plaques. Furthermore, patients with DR were 3.8 times (95% CI, 1.4 to 10.2) more likely to have CIMT thickening.ConclusionThese results suggest that CAN is associated with carotid atherosclerosis, represented as CIMT and plaques, independent of the traditional cardiovascular risk factors in T2DM. CAN or DR may be a determinant of subclinical atherosclerosis in T2DM.

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The correlation of common carotid arterial diameter with atherosclerosis and diabetic retinopathy in patients with type 2 diabetes mellitus

Cited by 28 publications

References 32 publications

The correlation of carotid artery calcification on panoramic radiographs and determination of carotid artery atherosclerosis with ultrasonography

The correlation of carotid artery calcification on panoramic radiographs and determination of carotid artery atherosclerosis with ultrasonography

Serum uric acid predicts vascular complications in adults with type 1 diabetes: the coronary artery calcification in type 1 diabetes study

Association between Cardiac Autonomic Neuropathy, Diabetic Retinopathy and Carotid Atherosclerosis in Patients with Type 2 Diabetes

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