The correlation of hyperopia and choroidal thickness, vessel diameter and area

Kaderli, Ahmet; Acar, Mehmet Akif; Ünlü, Nurten; Üney, Güner; Örnek, Firdevs

doi:10.1007/s10792-017-0509-3

“…It has been previously reported that an increased macular choroidal thickness correlates with hypermetropia, so in consequence it correlates with a short AL [17, 18]. However, other studies, including our study, show that CT of hypermetropic anisometropic amblyopic eyes is thick, even when the difference in the AL or refractive error between amblyopic and fellow eyes is taken into account in the statistical analysis [10, 12, 19].…”

Section: Discussioncontrasting

confidence: 41%

Effect of amblyopia treatment on choroidal thickness in hypermetropic anisometropic amblyopia using swept-source optical coherence tomography

Araki

¹

,

Miki

²

,

Goto

³

et al. 2018

View full text Add to dashboard Cite

BackgroundRecent studies using optical coherence tomography (OCT) have indicated that choroidal thickness (CT) in the anisometropic amblyopic eye is thicker than that of the fellow and normal control eyes. However, it has not yet been established as to how amblyopia affects the choroid thickening. The purpose of the present study was to investigate the effect of amblyopia treatment on macular CT in eyes with anisometropic amblyopia using swept-source OCT.MethodsThirteen patients (mean age: 6.2 ± 2.4 years) with hypermetropic anisometropic amblyopia were included in this study. Visual acuity (VA), axial length (AL), and CT were measured at the enrollment visit and at the final visit, after at least 6 months of treatment. CT measurements were corrected for magnification error and were automatically analyzed using built-in software and divided into three macular regions (subfoveal choroidal thickness (SFCT), center 1 mm, and center 6 mm). A one-way analysis of covariance using AL as a covariate was performed to determine whether CT in amblyopic eyes changed after amblyopia treatment.ResultsThe average observation period was 22.2 ± 11.0 months. After treatment, VA (logMAR) improvement in the amblyopic eyes was 0.41 ± 0.19 (p < 0.001). SFCT, center 1 mm CT, and center 6 mm CT were significantly thicker in the amblyopic eyes compared with the fellow eyes both before and after treatment (p < 0.05 for all comparisons). There were no significant changes in SFCT, center 1 mm CT, or center 6 mm CT before and after treatment in the amblyopic (p = 0.25, 0.21, and 0.84, respectively) and fellow (p = 0.75, 0.84, and 0.91, respectively) eyes. The correlation between changes in logMAR versus changes in CT after treatment was not significant.ConclusionsAlthough VA in amblyopic eyes was significantly improved after treatment, the choroid thickening of anisometropic amblyopic eyes persisted, and there was no significant change found in the CT after the treatment. Our findings suggest that thickening of the CT in amblyopia is not directly related to visual dysfunction.

show abstract

“…They believed that, in the early stages of myopia, choroidal thinning occurred before retinal thinning. Kaderli et al [ 25 ] found that the macular choroid thickened with an increase in hyperopia and a decrease in AL. At the same time, their study also found that the diameter and area of blood vessels in the macular choroid also increased.…”

Section: Discussionmentioning

confidence: 99%

Retinal and Choroidal Changes in Children with Moderate-to-High Hyperopia

Yu

¹

,

Ma

²

,

Lin

³

et al. 2021

Journal of Ophthalmology

View full text Add to dashboard Cite

Purpose. This study aimed to investigate the characteristics of retinal nerve fiber layer (RNFL) thickness, ganglion cell layer (GCL) thickness, and choroidal thickness in children with moderate-to-high hyperopia (MHH). Methods. This was a cross-sectional study that enrolled 53 children with MHH and 53 emmetropic children. Subjects with a spherical equivalent refraction (SER) of +4.0 D or higher were included in the MHH group, and subjects with SER between −1.0 D and +1.0 D were included in the emmetropic group. Ophthalmic examinations, including uncorrected visual acuity, cycloplegic refraction, slit-lamp examination, axial length, and swept-source optical coherence tomography (SS-OCT; DRI OCT Triton-1, Topcon, Tokyo, Japan), were performed. Results. The RNFL and GCL in the temporal and inferior quadrants in 1–3 mm of the macular fovea were thinner in the MHH group than in the emmetropic group (all P < 0.05 ). The MHH group also had a thicker choroidal thickness in all regions (all P < 0.05 ). The SER was independently correlated with the average choroidal thickness in the optic disc and fovea (coefficient = 4.853, P < 0.001 for the optic disc; coefficient = 5.523, P = 0.004 for the fovea), while axial length was negatively correlated with choroidal thickness (coefficient = −12.649, P < 0.001 ). Axial length was positively associated with RNFL and GCL thickness in the temporal quadrant in 1–3 mm of the macular fovea (coefficient = 0.966, P = 0.007 for RNFL and coefficient = 1.476, P = 0.011 for the macular fovea). Conclusion. Compared with emmetropic children, MMH children had greater choroidal thickness. The characteristics of the RNFL and GCL thickness in MMH children were different from those in emmetropic children.

show abstract

“…Several factors such as age, axial length, refractive error, and race can affect the choroidal thickness measurements. [ 16 17 18 ] In this study, the control subjects were matched with the cases for age, sex, and axial lengths. Thus, it is unlikely that the wide range of refractive errors in our cases could have contributed to the significant difference in the choroidal thickness between the case and control groups.…”

Section: Discussionmentioning

confidence: 99%

Choroidal and retinal thickness variations in ocular albinism

Venkatesh

¹

,

Agrawal²,

Reddy³

et al. 2022

Indian Journal of Ophthalmology

3

0

View full text Add to dashboard Cite

Purpose: To study the retinal and choroidal thickness variations on enhanced depth imaging optical coherence tomography scans in ocular albinism (OA) and compare with age-matched healthy subjects. Methods: This retrospective observational study had 48 eyes of 24 patients diagnosed clinically as OA and age, sex, and axial length-matched control healthy subjects. All patients underwent detailed ophthalmic examination and a single-line horizontal-raster enhanced depth imaging – optical coherence tomography scan (Spectralis, Heidelberg Engineering). Retinal and choroidal thickness was measured, compared, and analyzed between the two groups. Mann–Whitney U test was used for analysis between the two groups. P < 0.05 was considered significant. Results: The mean age was 28.3 ± 11.6 and 29.9 ± 10.6 years in the OA group and control group, respectively. Spherical equivalents ranged from −8.5D to +10.5D in the OA group and from −8.0D to +10.0D in the control group. The mean axial length between the two groups ( P = 0.652) were comparable. The average retinal thickness (272 ± 34.3 vs. 213 ± 13.8 mm; P < 0.001) was greater in the OA group as compared to controls. The mean choroidal thickness (184 ± 78.4 vs. 287 ± 46.4 mm; P < 0.001) was significantly thinner in the OA group. Conclusion: Acquisition of OCT scans in OA can be challenging. This study showed that the subfoveal retinal thickness and choroidal thickness measured across the scans were significantly different in the OA group compared to controls. In the future, more studies are required to evaluate the role of the choroid and its relationship to emmetropization in albinism.

show abstract

The correlation of hyperopia and choroidal thickness, vessel diameter and area

Cited by 15 publications

References 22 publications

Effect of amblyopia treatment on choroidal thickness in hypermetropic anisometropic amblyopia using swept-source optical coherence tomography

Effect of amblyopia treatment on choroidal thickness in hypermetropic anisometropic amblyopia using swept-source optical coherence tomography

Retinal and Choroidal Changes in Children with Moderate-to-High Hyperopia

Choroidal and retinal thickness variations in ocular albinism

Contact Info

Product

Resources

About