The Correlation of Irisin Levels and Some Trace Element as a Potential Mark Diagnosis of Gestational Diabetes Mellitus

Abstract

Abstract- The objective of this project was investigating and comparing changes of serum irisin, and trace levels of the elements (Zn, Cu, Mg) in pregnant women with gestational diabetes mellitus GDM in addition to wholesome pregnant group, examining the correlation among (Zn, Cu, Mg) levels and irisin insulin impedance in GDM pregnant women. Sixty GDM pregnant women and thirty wholesome pregnant women were examined. The pair groups were matched for age, and maternal serum irisin. Insulin levels and gestational age were calculated by the assay for enzyme-linked immune sorbent kit at gestation at 24-28 weeks. The confederation between clinical and biochemical parameters and maternal serum irisin levels were predestined. Serum levels of glucose, body mass index, insulin, OGTT, HOMA IR, HOMAβ, HbA1c, Hb%, irisin, Zn, Cu and Mg were investigated and analyzed for the examined collection as well as control samples. Pregnant women with GDM disease had noteworthy rising fast blood glucose FBG (P=0.004), first-hour OGTT glucose (P=0.001), second-hour OGTT glucose (P=0.001), fasting insulin FI (P=0.001) levels, HOMA IR (P=0.001), HOMAβ (P=0.001), HbA1C (P=0.001), Hb% (P=0.017), as contrasted to healthy women. Levels of irisin serum were significantly minimizing (P=0.001) in women, and sequentially more advanced GDM (mean±SD=71.65±8.03) than healthy pregnant controls (mean±SD 136.54±22.56). Analyses among irisin levels of anthropometric and biochemical values in gestational diabetes patients disclosed that none of the scrupulousness values were remediated with serum irisin level. His present outcomes indicate that the levels of serum irisin might be presented as an incoming GDM marker with decreased irisin levels being GDM symptomatic.

Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus

“…AL-Ghazali et al [ 128 ] also confirmed that serum irisin levels in pregnant women with GDM are significantly lower compared to healthy pregnant women. These results, according to the authors of the study, may suggest compensation for the physiological increase in insulin resistance or a stimulatory effect of high estrogen concentrations [ 128 ].…”

“…AL-Ghazali et al [ 128 ] also confirmed that serum irisin levels in pregnant women with GDM are significantly lower compared to healthy pregnant women. These results, according to the authors of the study, may suggest compensation for the physiological increase in insulin resistance or a stimulatory effect of high estrogen concentrations [ 128 ]. It also takes into account possibly its additional secretion by the placenta, although the effect of placental tissue on circulating irisin appears to be insignificant [ 129 ].…”

Clinical Significance of Neuregulin 4, Afamin, and SERPINB1 in Gestational Diabetes Mellitus and Their Relationship with Insulin Resistance

“…Biochemical variables were evaluated in our study in response to the correlation between these and AFM, and we discovered that serum AFM level was significantly positively related to insulin levels, fasting glucose levels, and HOMA-IR values. Although there was no direct evidence supporting our above finding, other GDM studies confirmed that significantly higher levels of fasting blood glucose, fasting insulin, and HOMA-IR were revealed in pregnant women with GDM than that in controls [ 25 ]. Akbas et al also demonstrated that these three biomarkers were increased in GDM patients compared to the controls, and serum cortistatin related to GDM was negatively correlated with these biomarkers [ 21 ].…”

“…KA0831, Bio-Techne China Co. Ltd. Shanghai, China) and a human Insulin Quantikine Enzyme-linked immunosorbent assay (ELISA) kit (DINS00, Bio-Techne China Co. Ltd. Shanghai, China). Homeostatic model assessment of insulin resistance (HOMA-IR) was calculated using the following formula: fasting glucose (mmol/L) × fasting insulin (IU/mL)/22.5 [ 25 ].…”

Los colores del tejido adiposo y la relación con la irisina

“…En las mujeres embarazadas, la irisina se secreta tambien en la placenta y su concentración aumenta durante la gestación. Los estudios en mujeres con DM gestacional son escasos y con datos controversiales, pero se ha señalado que la irisina se encuentra disminuida en comparación con las mujeres embarazadas sanas y se ha propuesto como marcador para la DM gestacional 35 .…”