The correlation of metal content in medicinal plants and their water extracts

Ranđelović, Saša; Kostić, Danijela A.; Zarubica, Aleksandra; Mitić, Snežana S.

doi:10.2298/hemind120703098r

Cited by 17 publications

(10 citation statements)

References 21 publications

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“…The results of antioxidant activity of aqueous and ethanol C. hederifolium extracts, estimated by five different methods are shown in Table 3. essential [32,33] . The composition of minerals found in the plant material depends on species, parts of the plant, tendencies to take over and accumulate metals from soil, type of the growing environment (urban, industrial, rural, wilderness, etc.)…”

Section: Antioxidant Activitymentioning

confidence: 99%

Chemical and pharmacological characterization of aqueous and ethanolic extracts of Cyclamen hederifolium Ait. (Primulaceae) tuber

et al. 2021

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Background / Aim. Cyclamen hederifolium Ait. belongs to the family Primulaceae, which comprehends 23 species of cyclamen, naturally distributed in the Central and Southern Europe, Western Asia and some parts of North Africa. This plant is considered highly poisonous and not suitable for human use. However, tuber extracts have been used in traditional medicine and homeopathy. We have evaluated C. hederifolium growing naturally in Serbia for its metal content and biological activities (antioxidant, antibacterial, antifungal and cytotoxic activity). Methods. Content of metals was determined by atomic absorption spectrophotometric method. We used several different assays for assessment of antioxidant activity of both aqueous and ethanol extracts of C. hederifolium: DPPH radical scavenging assay, ABTS radical scavenging assay, Ferric-reducing antioxidant power (FRAP) assay, Total reducing power assay (TRP) and Cupric reducing antioxidant capacity (CUPRAC) assay. The disk diffusion assay was used to investigate sensitivity of laboratory bacterial and fungal control strains against investigated extracts. Aqueous and ethanol extracts of C. hederifolium were examined on 4 different tumoral cell lines by in vitro MTT bioassay. Results. The presence of Mn, Ca, Mg, Fe, Zn, K, Cu was confirmed in aqueous and ethanol extract, as well as in whole tubers and soil, while Cr, Ni, Pb and Cd were not detected. Both aqueous and ethanol extract of C. hederifolium tubers exhibited antioxidant activity, that positively correlates to content of phenols and flavonoids in it. Aqueous extract was slightly superior in these terms than ethanol extract. None of the tested extracts showed antimicrobial activity. Both investigated extracts showed cytotoxicity against four cancer cell lines 4T1, HCT116, CT26, LLC1, in the concentration range 15.625-2000 μg/ml. Ethanol extract showed stronger cytotoxicity than aqueous extract. Conclusion. Seven metals have been identified in the C.hederifolium tubers, extracts and soil. Both extracts exhibited antioxidant and cytotoxic activity.

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Section: Antioxidant Activitymentioning

confidence: 99%

Chemical and pharmacological characterization of aqueous and ethanolic extracts of Cyclamen hederifolium Ait. (Primulaceae) tuber

et al. 2021

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“…Besides, being essential in the living system, the elements can be at the same time toxic, when at concentrations beyond those necessary for metabolic functions. [9][10][11] Brazil possesses one of the greatest vegetal genetic diversity of the world, accounting for approximately 20% of all known living species globally; 12 over one thousand species of plants are estimated to be used as medicine by the population. However, to be used by the Public System of Health, the National Agency for Sanitary Vigilance establishes that toxicological risks and the absence of toxic chemical substances must be within safe proven limits.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Major and Trace Elements in Medicinal Plants

Silva¹,

Francisconi²,

Gonçalves³

2016

Journal of the Brazilian Chemical Society

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This study presents the elemental concentration results obtained from 59 medicinal plants used in Brazil, determined by instrumental neutron activation analysis (INAA), inductively coupled plasma-optical emission spectrometry (ICP OES) and cold vapor atomic absorption spectrometry (CV AAS). The selected plant species were chosen from the Brazilian National Agency for Sanitary Vigilance (ANVISA) list of herbs recommended for utilization by the Public System of Health in Brazil (SUS). The results showed that high levels of foreign matter were found in almost 50% of the analyzed samples. The concentration of the elements varied in a wide range, although, generally in accordance with values found in literature. High concentrations of Ba, Cr, Fe, Hg, Se and Ni were found in some samples. The enrichment factor indicated that potentially hazardous elements can be accumulated mainly in the bark of the plants, possibly indicating an anthropogenic contribution.

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“…The concentrations of PTEs in hot water extracts prepared from medicinal plants are affected by the OM content that can chelate them, solubility of each PTE and the quality of the water used 25. Furthermore, the extraction of PTEs from leaves appeared to depend on their total concentrations and leaf maturity.…”

Section: Discussionmentioning

confidence: 99%

Trace Elements in Leaf Extracts of Eucalyptus grandis Traditionally Used to Treat Common Cold and Flu

Kanda

Goronga

2019

Journal of Health and Pollution

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Background. Eucalyptus species have been used for the remediation of mine tailings dams in Zimbabwe. However, a traditional medicinal remedy (TMR) for the treatment of mild acute respiratory infections, such as common cold and flu includes the use of Eucalyptus leaves. Objectives. The aim of the present study was to determine total concentrations of selected potentially toxic trace elements (PTEs) in gold mine tailings and leaves of Eucalyptus grandis and to identify extractable fractions of PTEs in leaves via boiling for 10 minutes in water, which is the process used to create TMRs to treat common cold and flu. Methods. Mine tailings and leaves of E. grandis were randomly collected at a gold mine tailings dam between April and June 2019. They were digested for laboratory analysis using standard analytical methods. Leaves were boiled in water for 10 minutes to prepare the TMR as practiced by the local community. The concentrations of PTEs were determined spectrometrically. Significant differences between PTEs in young and mature leaves were determined by analysis of variance. Results. Mine tailings were acidic (pH 4.52±0.62) with very low content of organic matter (0.02%) and contained PTEs in increasing concentrations of cadmium (Cd) < nickel (Ni) < lead (Pb) < chromium (Cr) < copper (Cu) < zinc (Zn) (n = 27). Mature leaves of E. grandis had higher concentrations than young leaves for Cr, Pb and Zn (p <0.05) which were lower than permissible limits in medicinal plants. Overall, boiling leaves in water for 10 minutes resulted in low extraction of PTEs (< 20%). Participant Consent. Obtained Conclusions. Concentrations of PTEs in leaves and leaf extracts of E. grandis were very low. However, TMRs should not be prepared from medicinal plants growing on metalliferous environments, such as mine tailings dams, due to the presence of cumulative toxins such as Cd and Pb. Further studies are needed to investigate the effect of various boiling times and should include arsenic in the studied PTEs. Competing Interests. The authors declare no competing interests for this study.

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The correlation of metal content in medicinal plants and their water extracts

Cited by 17 publications

References 21 publications

Chemical and pharmacological characterization of aqueous and ethanolic extracts of Cyclamen hederifolium Ait. (Primulaceae) tuber

Chemical and pharmacological characterization of aqueous and ethanolic extracts of Cyclamen hederifolium Ait. (Primulaceae) tuber

Evaluation of Major and Trace Elements in Medicinal Plants

Trace Elements in Leaf Extracts of Eucalyptus grandis Traditionally Used to Treat Common Cold and Flu

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