The Correlation of Pericoronary Adipose Tissue with Coronary artery disease and left ventricular function

Abstract

Objective: To investigate the correlation of pericoronary adipose tissue with coronary artery disease and left ventricular function.Methods: Participants with clinically suspected coronary artery disease were enrolled. All participants underwent coronary computed tomography angiography (CCTA) and echocardiography followed by invasive coronary angiography (ICA) within 6month. pericoronary adipose tissue (PCAT) was extracted to analyze the correlation with Gensini score and left ventricular function parameter, including IVS, LVPW, LVEDD, LVESD, LVEDV, LVESV, FS, LVEF, LVM, LVMI. The correlation between PCAT and Gensini was assessed by using Spearman correlation analysis, and between PCAT volume or FAI and left ventricular function parameters was assessed by using partial correlation analysis.Results: One hundred and fifty-nine participants (mean age, 64.55years ±10.64, male:65.4%[104/159]) were included for final analysis. The risk factors of coronary artery disease, such as hypertension, diabetes, dyslipidemia, history of smoking and drinking, had no significant association with the PCAT (P>0.05); and there is no correlation between PCAT and Gensini score. However, the LAD-FAI was positively correlated with IVS(r=0.203, P=0.013), LVPW(r=0.218, P=0.008),LVEDD(r=0.317, P＜0.001)，LVESD(r=0.298, P＜0.001), LVEDV(r=0.317, P＜0.001), LVESV(r=0.301, P＜0.001), LVM(r=0.371, P＜0.001), LVMI(r=0.304, P＜0.001). The LCX-FAI was positively correlated with LVEDD(r=0.199, P=0.015)，LVESD(r=0.190, P=0.021), LVEDV(r=0.203, P=0.013), LVESV(r=0.197, P=0.016), LVM(r=0.220, P=0.007), LVMI(r=0.172, P=0.036). The RCA-FAI was positively correlated with LVEDD(r=0.258, P=0.002)，LVESD(r=0.238, P=0.004), LVEDV(r=0.266, P=0.001), LVESV (r=0.249, P=0.002), LVM(r=0.237, P=0.004), LVMI(r=0.218, P=0.008). The total volume was positively correlated with FS (r=0.167, P=0.042).Conclusion: The FAI was positively correlated with the left ventricular function, but was not associated with the severity of coronary artery disease.