Background: Safe nursing care and professional commitment are known as two important components influencing the nursing service quality. Objectives: The present study aimed to assess the relationship between safe nursing care and nurses’ professional commitment. Methods: In the present cross-sectional correlational research, 263 nurses were selected from the intensive care unit/cardiac care unit (ICU/CCU), internal, surgery, pediatrics, gynecology and obstetrics, oncology, burn, orthopedics, infectious, and neurology wards of educational-therapeutic hospitals affiliated with Qazvin University of Medical Sciences by quota sampling method between May 2022 and September 2022. Data collection was performed using the nurses’ professional commitment scale (NPCS) and the assessment of safe nursing care (ASNC) questionnaire. Nurses were selected using a convenience sampling method. The collected data were analyzed using descriptive and inferential statistical tests (t-test, Pearson’s correlation, and one-way analysis of variance (ANOVA)) by SPSS software version 16. Results: The mean scores of nurses’ professional commitment and safe nursing care were 86.16 ± 4.92 and 134.57 ± 16.15, respectively. Pearson’s correlation test showed a significant relationship between nurses’ professional commitment and safe nursing care (r = 0.345, P ≤ 0.001). Also, the test results indicated that the level of nurses’ professional commitment varied among individuals with different employment types (P = 0.008). Conclusions: According to this study, safe nursing care and nurses’ professional commitment are two important components influencing each other. Therefore, these results have important implications for policymakers and healthcare systems involved in promoting the level of safe nursing care and nurses’ professional commitment.