The correlation of serum levels of leptin, leptin receptor and NO x (NO2 − and NO3 −) in patients with obstructive sleep apnea syndrome

Abstract

The aim of this study was to investigate the relations between nitric oxide (NO) and leptin levels in a cohort of untreated adult Obstructive sleep apnea syndrome (OSAS) patients. Between June 1, 2012, and January 1, 2013, we evaluated a total of 58 subjects including 36 OSAS patients and 22 healthy controls, both polysomnographically confirmed. Following the completion of polysomnographic evaluation, serum samples were taken at 08:00. Leptin, leptin receptor, NO2 (-) and NO3 (-) levels were analyzed by commercial ELISA kits. Data analysis was performed using the Statistical Package for the Social Sciences (SPSS) version 16.0 (SPSS Inc., Chicago, IL, USA). There was no statistically significant difference between the OSAS patients and control groups with relation to the demographic parameters and body mass index (p > 0.05). Significantly higher serum leptin and plasma NO levels were found in OSAS patients compared to the controls (p < 0.001). In this study, higher leptin levels which were positively correlated with NO levels in OSAS group may indicate a possible link with increased incidence of airway pathologies in these patients.

The Association Between Serum/Plasma Leptin Levels and Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression

“…Then another 26 articles were excluded for the different reasons indicated in Figure 1 . As shown in Table 1 , three were conducted in China ( 18 , 29 , 45 ), five in the USA ( 14 , 34 , 42 ), four in Poland ( 19 , 21 , 31 ), nine in Turkey ( 11 , 13 , 20 , 32 , 35 , 38 , 44 , 46 ), five in Spain ( 12 , 22 , 37 ), one in Australia ( 23 ), three in India ( 24 , 40 ), three in Greece ( 26 , 30 ), three in Italy ( 33 , 41 ), one in Brazil ( 36 ), two in Belgium ( 43 ), one in Egypt ( 15 ). With regard to ethnicity, 33 studies were performed with Caucasians ( 11 – 14 , 19 – 23 , 26 , 30 – 35 , 37 , 38 , 41 – 44 , 46 ), 11 with Asians ( 18 – 25 , 29 , 39 , 40 , 45 ), and one with Latinos ( 36 ) of the 45 studies, 13 reported leptin levels in plasma ( 12 , 14 , 19 , 22 , 30 , 33 , 42 , 46 ), and 32 ( 11 , 13 , 15 , 20 , 21 <...>…”

“…Thirteen are cross-sectional study ( 13 , 26 , 28 , 32 , 37 , 39 , 40 , 42 , 43 ). Thirty-one are case-control study ( 11 , 12 , 14 , 15 , 18 – 23 , 25 , 27 , 29 – 31 , 33 – 36 , 38 , 41 , 44 – 46 ). Nine studies included children ( 14 , 29 , 34 , 42 , 43 , 45 ).…”

“…Kapusuz et al. ( 11 ) showed that patients with OSAS have higher circulating levels of leptin compared to controls. But the association between OSAS and serum/plasma leptin levels is intricate and multidirectional because obesity alone can also affect leptin levels.…”

Plasma Leptin Levels, Obstructive Sleep Apnea Syndrome, and Diabetes Are Associated with Obesity-Related Alterations of Peripheral Blood Monocyte Subsets

“…The specific influence of obesity and OSAS on individual plasma leptin levels is controversially discussed. Some studies suggested that OSAS patients have higher plasma levels of leptin ( 43 ), whereas others observed no differences in serum leptin between OSAS patients and controls ( 44 ). Further, there is strong evidence that leptin is also involved in the regulation of cell-mediated inflammatory processes.…”

Distinguishing the impact of distinct obstructive sleep apnea syndrome (OSAS) and obesity related factors on human monocyte subsets

“…The impact of obesity and OSAS on plasma leptin levels is up to now controversially discussed in the literature. Some studies suggested that OSAS patients have higher plasma levels of leptin 45 , while others observed no differences in serum leptin between OSAS patients and controls 46 . Our data clearly underline that elevated fat mass as seen in obesity is the major amplifying factor among these two conditions 46 .…”