The Correlation of Serum Myeloid-Related Protein-8/14 and Eosinophil Cationic Protein in Patients with Coronary Artery Disease

Abstract

Objective. To investigate the changes in serum Myeloid-Related Protein 8/14 (MRP8/14) and Eosinophil Cationic Protein (ECP) levels in patients with different types of coronary artery diseases (CAD) and assess the value of MRP8/14 and ECP detection in predicting CAD. Methods. 178 patients were divided into CAD group including unstable angina pectoris (UAP), acute myocardial infarction (AMI), and stable angina pectoris (SAP). Thirty-six individuals with normal coronary artery served as the control group. Serum MRP8/14 and ECP were measured by ELISA. The severity of coronary artery stenosis was assessed by the numbers of involved coronary artery branches and the sum of Gensini scores. Results. The MRP8/14 levels were significantly higher in AMI and UAP group than SAP and control group (P < 0.05). The levels of MRP8/14 in AMI group were also obviously higher than UAP group (P < 0.05). The ECP levels were obviously increased in AMI group, but there was no difference between SAP and UAP group (P > 0.05). The ECP was significantly increased in three impaired coronary arteries and obviously correlated with Gensini score (P < 0.01), whereas the MRP8/14 was obviously positively correlated with CRP (P < 0.01). Conclusions. Increased MRP8/14 levels suggest the instability of the atherosclerotic plaque. ECP reflects the severity of coronary arteries stenosis, predicting atherosclerosis burden. They may become the new biomarkers of CAD.

S100 Proteins As an Important Regulator of Macrophage Inflammation

“…It was shown that the expression of S100A8/A9 was high in human atherosclerotic lesions and the blood levels were also increased in the patients with coronary artery diseases (CAD), which implied S100A8/A9 might act as a biomarker for cardiovascular events ( 143 ). Recent research has shown similar findings that serum S100A8/A9 levels were elevated in 178 CAD patients with unstable angina pectoris or acute myocardial infarction, and the level of S100A8/A9 was significantly positively linked with CRP ( P < 0.01) ( 144 ). These clinical data suggest that S100A8/A9 may become a novel biomarker for CAD ( 139 ).…”

Characterization and implications of the dynamics of eosinophils in blood and in the infarcted myocardium after coronary reperfusion

“…ECP, a marker of eosinophil activity, is released by cell degranulation and participates in the activation of the coagulation cascade. It has been previously reported that ECP can increase in the whole spectrum of stable and unstable ischemic heart disease [ 27 , 28 ]. In STEMI patients we detected raised ECP levels upon patient arrival that returned to control levels 1 month post-reperfusion.…”

Interplay between inflammation and thrombosis in cardiovascular pathology

“…Eosinophils are also implicated in atherosclerosis. The plasma levels of eosinophil cationic protein are positively correlated with the extent of atherosclerosis in patients with coronary artery disease 167 , 168 . The eosinophil chemokine eotaxin (also known as CCL11) is highly expressed in human atherosclerotic plaques 169 – 171 .…”