Obstructive sleep apnea (OSA) is a sleep-related breathing disorder caused by repeated upper airway obstruction. In OSA patients, 46.5%-58% reported having symptoms of hypersomnolence or excessive daytime sleepiness, and it was the most common symptom. Nasal obstruction is considered a risk factor for sleeping and breathing problems and a common problem in OSA sufferers. Nasal obstruction in the general population can reach 30-40% and is a problem that is often consulted in primary or secondary health services. This study aimed to determine the relationship between the degree of nasal obstruction and OSA in students of the Faculty of Medicine, Indonesian Christian University, Class of 2018-2020. This study uses an analytic observation method with a cross-sectional approach. The number of samples of 74 people was obtained by purposive sampling technique. Respondents who met the criteria were assessed for the degree of nasal obstruction using the NOSE scale questionnaire, while OSA was assessed using the ESS questionnaire, and then the data were analyzed using the Chi-Square Test. The results of the Chi-Square statistical test obtained p value = 0.041. So it was concluded that there was a significant relationship between the degree of nasal obstruction and OSA in students of the Faculty of Medicine, Indonesian Christian University Class of 2018-2020.