The Correlative Study of Serum Pseudo-cholinesterase, Biological Parameters and Symptoms Among Occupational Workers

Tunsaringkarn, Tanasorn; Zapuang, Kalaya; Rungsiyothin, Anusorn

doi:10.1007/s12291-013-0322-3

Cited by 1 publication

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“…These two types are acetylcholinesterase (true cholinesterase, AChE), which occurs in higher concentration in central nervous system and the outer membrane of red blood cells, in addition to the cholinesterase present in plasma, liver, cerebrospinal fluid, and glial cells (pseudo-cholinesterase, p.ChE) [4]. The ratio of p.ChE to AChE in human plasma is 1000 to 1 [5]. During exposure to OP compounds, decrease in p.ChE activity usually falls first, followed by the decrease in red blood cell AChE activity.…”

Section: Introductionmentioning

confidence: 99%

Caspases as prognostic markers and mortality predictors in acute organophosphorus poisoning

Tallat

Hussien

Mohamed

et al. 2020

Journal of Genetic Engineering and Biotechnology

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Background: Organophosphorus (OP) compounds have been widely available for decades in agriculture for crop protection and as cheap pest controllers, which increases the rate of exposure and poisoning cases. Using serum cholinesterase as prognostic markers for the acute OP toxicity is controversial; therefore, we aim to find out prognostic biomarkers that best correlate with mortality and outcomes of patients with acute OP toxicity. Levels of serum oxidative stress biomarkers (malondialdehyde (MDA) and total antioxidant capacity (TAC)) and activity of the apoptotic biomarkers (caspase 3 and caspase 9) and pseudo-cholinesterase (p.ChE) were performed. Also, we evaluated the apoptotic capacity through determining the genotoxic effects and chromosomal abnormalities among OP intoxicated patients. Results: We found the activity of caspases and serum MDA and TAC were significantly increased after OP poisoning and decreased after the appropriate atropine and oxime treatment course. The ROC curve suggested caspases as mortality and outcome predictive markers for acute OP poisoning patients. However, OP poisoning cases before treatment showed significant DNA damage, and they did not show any chromosomal aberration. Conclusion: The mentioned results strongly suggest apoptotic-related markers (caspase 3, caspase 9) as prognostic markers for evaluation of the treatment, outcomes, and mortality rate in the acute OP toxicity patients.

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Section: Introductionmentioning

confidence: 99%