The Corticocortical Structural Connectivity of the Human Insula

Ghaziri, Jimmy; Tucholka, Alan; Girard, Gabriel; Houde, Jean‐Christophe; Boucher, Olivier; Gilbert, Guillaume; Descoteaux, Maxime; Lippé, Sarah; Rainville, Pierre; Nguyen, Dang Khoa

doi:10.1093/cercor/bhv308

Cited by 252 publications

(209 citation statements)

References 104 publications

Supporting

Mentioning

192

Contrasting

Unclassified

Order By: Relevance

“…Insula also predicts the probability of adverse outcomes from behavior choices (Preuschoff et al, 2008). Moreover, insula enjoys connections with almost every other site listed in Table 2 (Ghaziri et al, 2015), suggesting a role in coordinating those sites.…”

Section: Discussionmentioning

confidence: 99%

Children’s brain activation during risky decision-making: A contributor to substance problems?

Crowley

Dalwani

Sakai

et al. 2017

Drug and Alcohol Dependence

View full text Add to dashboard Cite

Objective Among young children excessive externalizing behaviors often predict adolescent conduct and substance use disorders. Adolescents with those disorders show aberrant brain function when choosing between risky or cautious options. We therefore asked whether similarly aberrant brain function during risky decision-making accompanies excessive externalizing behaviors among children, hypothesizing an association between externalizing severity and regional intensity of brain activation during risky decision-making. Method Fifty-eight (58) 9–11 year-old children (both sexes), half community-recruited, half with substance-treated relatives, had parent-rated Child Behavior Checklist Externalizing scores. During fMRI, children repeatedly chose between doing a cautious behavior earning 1 point or a risky behavior that won 5 or lost 10 points. Conservative permutation-based whole-brain regression analyses sought brain regions where, during decision-making, activation significantly associated with externalizing score, with sex, and with their interaction. Results Before risky responses higher externalizing scores were significantly, negatively associated with neural activation (t’s: 2.91 to 4.76) in regions including medial prefrontal cortex (monitors environmental reward-punishment schedules), insula (monitors internal motivating states, e.g., hunger, anxiety), dopaminergic striatal and midbrain structures (anticipate and mediate reward), and cerebellum (where injuries actually induce externalizing behaviors). Before cautious responses there were no significant externalizing: activation associations (except in post hoc exploratory analyses), no significant sex differences in activation, and no significant sex-by-externalizing interactions. Conclusions Among children displaying more externalizing behaviors extensive decision-critical brain regions were hypoactive before risky behaviors. Such neural hypoactivity may contribute to the excessive real-life risky decisions that often produce externalizing behaviors. Substance exposure, minimal here, was a very unlikely cause.

show abstract

Section: Discussionmentioning

confidence: 99%

Children’s brain activation during risky decision-making: A contributor to substance problems?

Crowley

Dalwani

Sakai

et al. 2017

Drug and Alcohol Dependence

View full text Add to dashboard Cite

show abstract

“…Hypoconnectivity within the insula has been previously reported and hypothesized as playing a role in alcohol relapse because of a diminished awareness of substance use (Camchong et al, 2012). Another possible explanation for the observed hypo-connectivity is the known damage to white matter caused by alcohol (Pfefferbaum et al, 2000) which disrupts the anatomical connection between left insula and lingual gyrus (Ghaziri et al, 2015). The insula and the putamen are regions that has been previously associated with the brain reward system and with different directions of effects including loss of connectivity (Kuceyeski et al, 2013) and increased connectivity (Zhu et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Alterations of resting state functional network connectivity in the brain of nicotine and alcohol users

et al. 2017

View full text Add to dashboard Cite

Alcohol and nicotine intake result in neurological alterations at the circuit level. Resting state functional connectivity has shown great potential in identifying these alterations. However, current studies focus on specific seeds and leave out many brain regions where effects might exist. The present study uses a data driven technique for brain segmentation covering the whole brain. Functional magnetic-resonance-imaging (fMRI) data were collected from 188 subjects: 51 non-substance consumption controls (CTR), 36 smoking-and-drinking subjects (SAD), 28 drinkers (DRN), and 73 smokers (SMK). Data were processed using group independent component analysis to derive resting state networks (RSN). The resting state functional network connectivity (rsFNC) was then calculated through correlation between time courses. One-way ANOVA tests were used to detect rsFNC differences among the four groups. A total of 50 ANOVA tests were significant after multi-comparison correction. Results delineate a general pattern of hypo-connectivity in the substance consumers. Precuneus, postcentral gyrus, insula and visual cortex were the main brain areas with rsFNC reduction suggesting reduced interoceptive awareness in drinkers. In addition, connectivity reduction between postcentral and one RSN covering right fusiform and lingual gyri showed significant association with severity of hazardous drinking. In smokers, connectivity changes agreed with the idea of a shift towards endogenous information processing, represented by the DMN. Hypo-connectivity between thalamus and putamen was observed in smokers. In contrast, the angular gyrus showed hyper-connectivity with the precuneus linked to smoking and significantly correlated with nicotine dependence severity. In spite of the presence of common effects, our results suggest that particular effects of alcohol and nicotine can be separated and identified. Results also suggest that concurrent use of both substances affects brain connectivity in a complex manner, requiring careful consideration of interaction effects.

show abstract

“…Previous studies have reported joint activity in these regions for tasks requiring self-judgment (Araujo et al, 2013) and social comparison (Beer & Hughes, 2010;Kedia, Lindner, Mussweiler, Ihssen, & Linden, 2013;Lindner et al, 2015;Moore et al, 2014). Moreover, research shows that these brain areas are structurally (Ghaziri et al, 2017) and functionally connected to each other (Cauda et al, 2012(Cauda et al, , 2011Dosenbach et al, 2006;Penner et al, 2016;Sridharan, Levitin, & Menon, 2008;Taylor, Seminowicz, & Davis, 2009). Therefore, we combined the values obtained for each of these ROIs in a 5 (region: AI, vACC, dACC, VMPFC, & DMPFC) × 2 (hemisphere: left vs right) × 2 (targets: self-other vs familiar-other) × 2 (direction: upward vs downward) × 2 (distance: high vs low) repeated measure ANOVA.…”

Section: Fmri Data: Roi Analysesmentioning

confidence: 94%

So pretty! The neural correlates of self-other vs familiar-other attractiveness comparisons

Kedia

Mussweiler

Adam

et al. 2017

Social Neuroscience

View full text Add to dashboard Cite

Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-pro t purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. Previous research has demonstrated that comparing two persons activates a frontoparietal network associated with numbers and nonsocial magnitudes. However, it is unclear whether this network is also recruited by comparisons involving the self. Self-reflection engages self-serving motivations (e.g., the maintenance of a positive self-image) and is associated with specific brain structures, such as the medial prefrontal cortex (MPFC), the anterior insula (AI) and the anterior cingulate cortex (ACC). Self-other comparisons may thus rely on distinct neural activity. To clarify this question, we used fMRI and asked female participants to compare their own attractiveness (or the attractiveness of a familiar woman) to pictures of unknown women. Participants were slower for comparisons with targets whose attractiveness was similar to their own (or their familiar other). Yet although this behavioral result resembles the distance effect reported for nonsocial magnitudes, at the brain level, it was linked to the activity of the AI, the ACC and the MPFC. The effect of distance in these regions was stronger for self-other than familiar-other comparisons. We interpret these results in relation to previous literature in social psychology and social neuroscience.

show abstract

The Corticocortical Structural Connectivity of the Human Insula

Cited by 252 publications

References 104 publications

Children’s brain activation during risky decision-making: A contributor to substance problems?

Children’s brain activation during risky decision-making: A contributor to substance problems?

Alterations of resting state functional network connectivity in the brain of nicotine and alcohol users

So pretty! The neural correlates of self-other vs familiar-other attractiveness comparisons

Contact Info

Product

Resources

About