The Cost-Effectiveness of Platelet-Rich Plasma Compared With Hyaluronic Acid Injections for the Treatment of Knee Osteoarthritis

Samuelson, Eric M.; Ebel, Jeffrey A.; Reynolds, Scott B.; Arnold, Ryan M.; Brown, David E.

doi:10.1016/j.arthro.2020.07.027

Cited by 31 publications

(28 citation statements)

References 37 publications

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“…All cost-effectiveness studies identified [40][41][42][43][44][45][46][47] are included in Table 4. Waddell et al 40 developed a cost-of-illness model to demonstrate potential savings associated with IAHA treatment in a managed care setting (Table 4).…”

Section: Cost-effectivenessmentioning

confidence: 99%

“…In the worst-case scenario (10% responder rate to IAHA), HMW IAHA was no longer cost-effective in any circumstance. 43 Samuelson et al 44 examined the cost-effectiveness of a series of intra-articular platelet-rich plasma injections (total of 3 injections) compared with IAHA for the treatment of symptomatic knee OA. In the model, the base case assumes an otherwise healthy individual presenting to an orthopedist's office as a new patient for the evaluation and treatment of symptomatic knee OA.…”

Section: Clinical Medicine Insights: Arthritis and Musculoskeletal Disordersmentioning

confidence: 99%

“…The authors concluded that both treatment options would be considered cost-effective, and platelet-rich plasma injections were not more cost-effective than IAHA injections. 44 Rosen et al 45 examined and compared the cost utility of different IAHA products relative to one another and to conventional care. A single US payer economic evaluation was conducted comparing multiple IAHA products.…”

Section: Clinical Medicine Insights: Arthritis and Musculoskeletal Disordersmentioning

confidence: 99%

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Intra-articular Hyaluronic Acid for Osteoarthritis of the Knee in the United States: A Systematic Review of Economic Evaluations

Mordin

Parrish²,

Masaquel

et al. 2021

Clin Med�Insights�Arthritis�Musculoskelet Disord

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Background: The economic impact of intra-articular hyaluronic acid (IAHA) for the treatment of knee pain associated with osteoarthritis (OA) has been evaluated in the United States, but not systematically summarized. Objective: We reviewed the literature to determine the economic impact of IAHA for pain associated with knee OA in the United States. Methods: A literature review was performed in PubMed (including MEDLINE and MEDLINE In-Process), Embase, the Cochrane Database of Systematic Reviews, and National Health Service Economic Evaluation Database and was limited to English language human studies published from January 2000 to October 2020. Results: The literature search identified 215 unique abstracts; of these, 47 were selected for full-text review and 21 studies met the inclusion criteria. Intra-articular hyaluronic acid injections delayed progression to total knee arthroplasty (TKA), and repeated courses of treatment successfully delayed TKA by more than 5 years. Intra-articular hyaluronic acid was found to reduce the use of pain medications overall and reduce the number of patients receiving opioid prescriptions by 6% ( P < .001). Several studies showed that IAHA is more cost-effective in treating pain associated with knee OA compared with conventional care with nonsteroidal anti-inflammatory drugs (NSAIDs), analgesics, and corticosteroids, and several authors concluded that IAHA should be the dominant treatment strategy. Conclusions: Current studies suggest that IAHA may reduce the use of pain medications, such as NSAIDs and opioids, and impact time to TKA procedures, thus potentially decreasing overall treatment costs of knee OA over time. Furthermore, IAHA was determined to be cost-effective against NSAIDs, corticosteroids, analgesics, and conservative treatment. As the safety and efficacy of IAHA for knee OA have been well established, the findings from our literature review may be used to inform future economic evaluations.

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Section: Cost-effectivenessmentioning

confidence: 99%

Section: Clinical Medicine Insights: Arthritis and Musculoskeletal Disordersmentioning

confidence: 99%

Section: Clinical Medicine Insights: Arthritis and Musculoskeletal Disordersmentioning

confidence: 99%

See 1 more Smart Citation

Intra-articular Hyaluronic Acid for Osteoarthritis of the Knee in the United States: A Systematic Review of Economic Evaluations

Mordin

Parrish²,

Masaquel

et al. 2021

Clin Med�Insights�Arthritis�Musculoskelet Disord

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“…Recently, research studying the efficacy of PRP in the treatment of knee OA found that PRP is superior to other intraarticular injectable options [23,24]. In addition to the benefits of pain and function improvements, a recent study found that it could prevent disease progression and decrease the likelihood of TKA while showing that it is more cost-effective when compared to HA injections [25,26]. Moreover, Luo et al studied the effect of PRP injections in overweight and obese patients and concluded that PRP was better in relieving pain and restoring function in that group [27].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Platelet-Rich Plasma on Pain and Function in the Treatment of Knee Osteoarthritis: A Prospective Cohort Study

Hegaze

Hamdi

Alqrache

et al. 2021

Cureus

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Background Osteoarthritis (OA) is a degenerative disease commonly affecting the knee joints. It affects patients socially, psychologically and economically and rates of the disease have been increasing due to obesity and old age. Regardless of choosing a medically conservative approach, it is a challenge in the long term to provide OA patients efficient treatment with minimal side effects and long-term efficiency. Platelet-rich plasma (PRP) is a convenient, low-cost and affordable treatment technique used in treating knee OA with encouraging efficient and safe outcomes. In this study we will investigate the effect of PRP on knee OA. Methods This is a prospective cohort study involving 252 patients with different OA grades. The Kellgren and Lawrence (K&L) system was used in classifying the affected knee by degenerative cartilage lesions as well as early and severe OA. All patients with a diagnosis of knee OA were screened in every visit before the injection, the pain was assessed by the 0-10 Numeric Rating Scale (NRS), and knee range of motion including flexion and extension was assessed by goniometer. Follow-up appointments were done on three-month intervals for a total of three visits for evaluation. Injection of PRP was given to all the patients with a maximum of four injections. The results were evaluated statistically according to the total number of followup visits. Results In grade II patients, the pain improved with the visits and the maximum improvement in flexion degree was noticed in patients who came for a total of three follow-up visits. In grade III patients, the most improvement in pain was in patients who came for three follow-up visits, while the most improvement in flexion degree was in patients who came for a total of two follow-up visits. Patients with grade IV who came for three follow-up visits showed the most improvement in pain and degree of flexion. Conclusions Intra-articular injections gave significant pain and flexion improvement in grades II, III and IV in OA patients, especially with multiple injection in the short-term follow-up. As a result, recommendation of repeated multiple injections up to four times is efficient in providing long time relief in knee OA.

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“…PRP does have a greater cost as compared to hyaluronic acid, however, out to one year and comparatively, it is, cost effective. 10,11 We know that the autologous use of mesenchymal stromal cells, mixed soft tissue progenitors administered both in the same day procedures, or when culture expanded are safe, with minimal adverse events as demonstrated in a multi-centric study of over 2,000 patients with average time of follow-up of more than 8 years. 12 Although the efficacy of the use of mesenchymal stromal cells are also not conclusive, the results of a recent metaanalysis of 35 studies in over 2,000 patients seems to suggest efficacy in improving pain, self-reported function, and cartilage quality.…”

Section: Editorial E6mentioning

confidence: 99%

Orthobiologics: Filling the Gaps in Current Orthopaedic Surgical Treatment

Murrell

2021

Bio Orthop J

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The Cost-Effectiveness of Platelet-Rich Plasma Compared With Hyaluronic Acid Injections for the Treatment of Knee Osteoarthritis

Cited by 31 publications

References 37 publications

Intra-articular Hyaluronic Acid for Osteoarthritis of the Knee in the United States: A Systematic Review of Economic Evaluations

Intra-articular Hyaluronic Acid for Osteoarthritis of the Knee in the United States: A Systematic Review of Economic Evaluations

Efficacy of Platelet-Rich Plasma on Pain and Function in the Treatment of Knee Osteoarthritis: A Prospective Cohort Study

Orthobiologics: Filling the Gaps in Current Orthopaedic Surgical Treatment

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