The Cost of Achalasia: Quantifying the Effect of Symptomatic Disease on Patient Cost Burden, Treatment Time, and Work Productivity

Nenshi, Rahima; Takata, Julie; Stegienko, Stacey; Jacob, Binu; Kortan, Paul P.; Deitel, Wayne; Laporte, Audrey; Darling, Gail; Urbach, David R.

doi:10.1177/1553350610376392

Cited by 26 publications

(13 citation statements)

References 10 publications

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“…Other researches also present good results because from very low initial GIQLI, they present GIQLI post-operatory with superior punctuation, but without reaching equal or higher values to the ones considered as normal, such as the ones from: Ferulano GP, et al [12], Decker G [7] and DeHaan RK, et al [13]. Nonetheless but Nenshi R, et al [14] present in his research a low GIQLI post-operatory result, reflecting a bad HRQL.…”

Section: Resultsmentioning

confidence: 86%

Health-Related Quality of Life and Long-term Results after Laparoscopic Heller Myotomy and Dor Fundoplication

Rr¹,

Mam²,

Rj³

et al. 2019

J Surg Open Access

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Introduction: Laparoscopic Heller myotomy is currently considered the choice treatment for relief of dysphagia in Esophageal Achalasia (EA), showing a low incidence of gastroesophageal reflux and evident improvement in Health-Related Quality of Life (HRQL).Objective: Evaluate Health-Related quality of life and clinic evolution after laparoscopic Heller myotomy and Dor fundoplication. Material and method:Prospective longitudinal descriptive observational study, through the application of the Gastrointestinal Quality of Life Index questionnaire (GIQLI) to patients underwent surgery for EA from January 2010 to December 2017 at the National Center for Minimally Invasive Surgery. The questionnaire was applied before surgery and one year later. Statistical analysis:Percentages for qualitative variables, mean ± standard deviation or median and range, as appropriate for quantitative variables, for the comparison of the questionnaire results, we used student's t-test, with statistical significance level α=0.05.Results: 101 patients were included in the study, three of them were excluded. Age ranged from 18 to 78 years with an average of 47 years. The mean time of evolution of the symptoms was 62 months, with an average of 3.3 on the dysphagia scale and a Resting Pressure of the lower esophageal sphincter (mmHg) 38.7 ± 16.8, an initial GIQLI of 85 was obtained, 3 ± 20.4, which increased twelve months after surgery to 131.6 ± 10.5. Conclusions:Heller myotomy and Dor fundoplication improve Health-Related quality of life in patients with esophageal achalasia with good outcomes in time.

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Section: Resultsmentioning

confidence: 86%

Health-Related Quality of Life and Long-term Results after Laparoscopic Heller Myotomy and Dor Fundoplication

Rr¹,

Mam²,

Rj³

et al. 2019

J Surg Open Access

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“…12) Moreover, the disease may increase economic and healthcare burdens, and decrease work productivity, which greatly impair patients' QOL. 13) Some studies 13,14) have demonstrated that QOL scores for AC patients were lower than that of general population. Among treatment methods for AC, POEM is a novel therapy, some studies have shown exciting short-term clinical efficacy.…”

Section: Discussionmentioning

confidence: 99%

The Outcomes and Quality of Life of Patients with Achalasia after Peroral Endoscopic Myotomy in the Short-Term

Liu

Tan

Yang

et al. 2015

ATCS

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IntroductionAchalasia (AC) is a rare esophageal motility disorder characterized by aperistalsis of the esophageal body and impaired lower esophageal sphincter (LES) relaxation. Clinical manifestations include dysphagia, regurgitation, chest pain, weight loss, etc. Current treatment modalities of achalasia include pharmacologic agents, endoscopic methods (such as intrasphincteric injection of botulinum toxin, pneumatic dilatation, and endoscopic retrievable stent placement), and surgery. 1) Pharmacological management such as calcium antagonists or nitrates has little effect. 2) Though endoscopic methods can relieve the symptoms and improve the life quality of AC patients, the long-term efficacy is disappointing. 3) Laparoscopic Heller Myotomy (LHM) is a standard surgical method for treating achalasia, and has demonstrated good long-term efficacy and life quality improvement. 4,5) However, this procedure is more invasive with longer hospital stay and greater cost compared with endoscopic methods. 6,7) Peroral endoscopic myotomy (POEM) is a novel treatment for achalasia, and has shown exciting results in limited

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“…One approach involved the use of a proprietary process to change the crystalline structure to an extended chain (Hyalamer®); it was anticipated that this change would result in a UHMWPE with superior material properties (e.g., yield strength and creep resistance) [108]. However, the clinical experience with this material demonstrated a high failure rate at early stage (<5 years) [109,110]. Another approach was to cross-link the polyethylene.…”

Section: Polyethylenementioning

confidence: 99%

Orthopedic Implant Retrieval and Failure Analysis

Jones

Tsao²,

Topoleski

2012

Degradation of Implant Materials

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Orthopedic devices make up a major percentage of the medical devices being implanted today. Success rates exceeding 95% have been reported. However, their longevity is compromised by fatigue, wear, corrosion, and other degradative mechanisms. Adverse biologic responses to products from these different mechanisms can lead to significant bone loss and may even compromise subsequent surgeries. It is imperative that we fully understand what mechanisms are in play and carefully evaluate strategies to minimize, if not eliminate, these degradation processes. Devices retrieved at revision surgery and at autopsy have provided us with important information regarding the performance of orthopedic implants. Surface characterization of the implant, biomechanical analyses, and histological analysis of the tissues surrounding the implant can provide us with information not available through other sources. This chapter will review the significance of retrieved implants to the long-term survival of these implants.

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The Cost of Achalasia: Quantifying the Effect of Symptomatic Disease on Patient Cost Burden, Treatment Time, and Work Productivity

Abstract: Achalasia substantially limits the lifestyle of patients with the disease. It also implies a financial burden of care for patients and leads to decreased work productivity.

Cited by 26 publications

References 10 publications

Health-Related Quality of Life and Long-term Results after Laparoscopic Heller Myotomy and Dor Fundoplication

Health-Related Quality of Life and Long-term Results after Laparoscopic Heller Myotomy and Dor Fundoplication

The Outcomes and Quality of Life of Patients with Achalasia after Peroral Endoscopic Myotomy in the Short-Term

Orthopedic Implant Retrieval and Failure Analysis

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