The costa of trichomonads: A complex macromolecular cytoskeleton structure made of uncommon proteins

Abstract

Our observations suggest the presence of a new class of the cytoskeleton filaments in T. foetus. We believe that our data could auxiliate in determining the specific locations of these proteins in the distinct regions that compose the costa, as well as to define the functional roles of each component. Therefore, our study will help in the better understanding of the organisation and function of this structure in unicellular organisms.

The parabasal filaments of Trichomonas vaginalis: A new filament and observations using 0.8 nm-resolution scanning electron microscopy

“…The costa has its origin in the basal body region, between the basal body (kinetosome) of the recurrent flagellum (R) ( Fig. 1 c) and kinetosomes #2 and #3 ( De Andrade Rosa et al, 2017 , Honigberg et al, 1971 ), and it is broader at the point at which it emerges. Here, we found that the initial costa region is wider and can reach 451 nm.…”

A comprehensive analysis of prefoldins and their implication in cancer

“…Other unexpected proteins that showed PFDN domains are found in the costa of protozoa of the Trichomonadidae family, a striated fiber that presents an undulating membrane ( de Andrade Rosa et al., 2017 ). Several studies have shown that ectopic expression of archaeal PFDN leads to an enhancement of the folding efficiency of different proteins.…”