2019
DOI: 10.1002/nbm.4182
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The costs and benefits of estimating T1 of tissue alongside cerebral blood flow and arterial transit time in pseudo‐continuous arterial spin labeling

Abstract: Multi-post-labeling-delay pseudo-continuous arterial spin labeling (multi-PLD PCASL) allows for absolute quantification of the cerebral blood flow (CBF) as well as the arterial transit time (ATT). Estimating these perfusion parameters from multi-PLD PCASL data is a non-linear inverse problem, which is commonly tackled by fitting the singlecompartment model (SCM) for PCASL, with CBF and ATT as free parameters. The longitudinal relaxation time of tissue T 1t is an important parameter in this model, as it governs… Show more

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Cited by 6 publications
(7 citation statements)
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“…We also did not correct for differences between cortical areas and basal ganglia as the slightly lower T1 time and shorter arterial transit times of the latter, where the labeled spins arrive earlier and spend more time relaxing with a shorter T1 time. 20 , 21 However, a possible resulting underestimation of basal ganglia CBF does not affect the comparison of parameters between patients and controls, which is the main aspect of the present study.…”
Section: Discussionmentioning
confidence: 76%
“…We also did not correct for differences between cortical areas and basal ganglia as the slightly lower T1 time and shorter arterial transit times of the latter, where the labeled spins arrive earlier and spend more time relaxing with a shorter T1 time. 20 , 21 However, a possible resulting underestimation of basal ganglia CBF does not affect the comparison of parameters between patients and controls, which is the main aspect of the present study.…”
Section: Discussionmentioning
confidence: 76%
“…Third, CBF quantification was performed twice, once using the population average T1b value, and once using the individually estimated T1b value. Finally, CBF values from GM voxels were isolated by downsampling and coregistering a GM mask to the CBF maps, following the procedure described in the work of Bladt et al 30 The GM mask was obtained from a high‐resolution anatomical image by means of multilevel image thresholding 31 . Potential differences in CBF estimation variability between using the recommended population average T1b value and using individually estimated T1b values were assessed by comparing the standard deviations of the set of GM CBF estimates, pooled over all subjects, for both quantification methods.…”
Section: Methodsmentioning
confidence: 99%
“…However, timings which maximize measurement precision may also be chosen objectively using the Cramér-Rao lower bound (CRLB), a statistical expression that describes the lower bound of the estimated parameter variances. 88 The use of the CRLB for finding optimal multi-timepoint protocol timings has been widely demonstrated for CBF and ATT estimation, 27,28,62,74,83,[89][90][91][92][93][94][95][96][97][98] and we recommend that CRLB optimized protocol timings are used for quantitative imaging, when possible, to maximize measurement precision and scan efficiency.…”
Section: Optimal Timingsmentioning
confidence: 99%