2004
DOI: 10.1387/ijdb.041796go
|View full text |Cite
|
Sign up to set email alerts
|

The countercurrent principle in invasion and metastasis of cancer cells. Recent insights on the roles of chemokines

Abstract: Chemokine production by cancer cells constitutes a duality. Leukocyte recruitment under the pressure of chemokines may be beneficial for the host or for the tumor. Here, the emphasis will be on the detrimental effects of chemokines in tumor biology. A decade ago, the countercurrent principle of tumor-derived chemokine and peritumoral protease production was formulated to explain chemokine expression as a selective advantage for specific tumors and as a phenotype of invasive and metastasizing cancer cells. Chem… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

1
39
0
2

Year Published

2004
2004
2018
2018

Publication Types

Select...
9
1

Relationship

1
9

Authors

Journals

citations
Cited by 60 publications
(42 citation statements)
references
References 70 publications
1
39
0
2
Order By: Relevance
“…In addition, various tumor cells constitutively express chemokines, for example, granulocyte chemotactic protein-2 (GCP-2/CXCL6), provoking leukocyte infiltration from blood vessels into the tumor tissue and thereby leaving a pathway of degraded extracellular matrix open for metastasis. 27,39 On the other hand, proteases can also influence other properties of chemokines, for example, DPP-IV/CD26-processed CCL5 was more potent at protecting CD4 ϩ cells against HIV-1 infection because of the increased affinity for CCR5. 14 NH 2 -terminal cleavage of CXCL10 by DPP-IV/CD26 impairs its CXCR3 signaling and chemoattractive capacity; however, it does not interfere with its antiangiogenic character.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, various tumor cells constitutively express chemokines, for example, granulocyte chemotactic protein-2 (GCP-2/CXCL6), provoking leukocyte infiltration from blood vessels into the tumor tissue and thereby leaving a pathway of degraded extracellular matrix open for metastasis. 27,39 On the other hand, proteases can also influence other properties of chemokines, for example, DPP-IV/CD26-processed CCL5 was more potent at protecting CD4 ϩ cells against HIV-1 infection because of the increased affinity for CCR5. 14 NH 2 -terminal cleavage of CXCL10 by DPP-IV/CD26 impairs its CXCR3 signaling and chemoattractive capacity; however, it does not interfere with its antiangiogenic character.…”
Section: Discussionmentioning
confidence: 99%
“…Unlike the situation in infection and inflammation where neutrophil mobilizing factors are secreted by endothelial cells and other stromal cells, in the context of cancer, neutrophil mobilizing factors are often secreted by the tumor cells themselves [22]. The most common neutrophil chemoattractants produced by tumors include IL-8 (CXCL8/CXCL2), MIP-1α (CCL3), huGCP-2 (CXCL6) and KC (CXCL1) [167][168][169][170][171]. G-CSF is ectopically expressed in several human tumors such as leukemia [172], bladder [173], pancreatic [174], cervical [175], ovarian [176], head and neck [177], colorectal [178] and breast carcinoma [179].…”
Section: Regulation Of Neutrophil Mobilization Recruitment and Activmentioning
confidence: 99%
“…34, 35; e.g., by attracting leukocytes loaded with proteases that can promote tumor invasion and metastasis; ref. 43). In addition, the expression of chemokine receptors contributes to metastasis of tumor cells to the organs where the corresponding chemokine is produced (44).…”
Section: Cancer Researchmentioning
confidence: 99%