The Course in Idiopathic Hypertrophic Muscular Subaortic Stenosis

Parker, Brent M.

doi:10.7326/0003-4819-70-5-903

Cited by 19 publications

(1 citation statement)

References 36 publications

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“…All these six patients were elderly, the youngest being 67 years; five died of carcinoma of various primary sites and the sixth of septicaemia associated with cholecystitis. The variability of the clinical course of hypertrophic obstructive cardiomyopathy is well recognized (Frank and Braunwald, 1968;Parker, 1969) and recently echocardiography has shown that asymmetrical septal hypertrophy can be present without any clinical evidence of heart disease (Henry, Clark, and Epstein, 1973). Henry and his colleagues (1973) put forward the concept of a spectrum of hypertrophic obstructive cardiomyopathy and our pathological study supports this suggestion.…”

Section: Discussionsupporting

confidence: 67%

Pathological features of hypertrophic obstructive cardiomyopathy

Davies¹,

Pomerance²,

Teare³

1974

J Clin Pathol

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Many pathologists will be familiar with the easily recognized asymmetrical hypertrophy seen in young and early middle-aged subjects, usually associated with sudden death. It is, however, not generally appreciated that hypertrophic obstructive cardiomyopathy is not necessarily asymmetrical or fatal or that it also occurs in older subjects. We have recently reviewed the pathology of 47 hearts with this feature and the present paper describes our findings, emphasizing those macroscopic features which are of diagnostic value in hearts where the hypertrophy is not of the easily recognized asymmetrical, septal type. MaterialThe diagnosis of hypertrophic obstructive cardiomyopathy was initially made on clinical history and 'In receipt of a grant from the British Heart Foundation.

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Section: Discussionsupporting

confidence: 67%

Pathological features of hypertrophic obstructive cardiomyopathy

Davies¹,

Pomerance²,

Teare³

1974

J Clin Pathol

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Development of severe left ventricular outflow tract obstruction over the course of 14 years: An unusual natural history of hypertrophic obstructive cardiomyopathy

Wilson

Razavi

1986

Cathet. Cardiovasc. Diagn.

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A patient with hypertrophic obstructive cardiomyopathy who when first seen had a normal physial examination, chest x-ray, and electrocardiogram, and no provokable gradient with isoproterenol at cardiac catheterization, was re-evaluated after 14 years. At the time of re-evaluation, she was found to have a typical systolic ejection murmur, cardiomegaly, left ventricular hypertrophy, a pseudoinfarction pattern on electrocardiography, and a significant subaortic gradient both by catheterization and by doppler. This case demonstrates that hypertrophic obstructive cardiomyopathy can be a progressive disease and that patients with this condition warrant careful follow-up. Echocardiography with doppler may provide an excellent noninvasive method of following these patients.

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