The course of gastric cancer following surgery is associated with genetic variations of the interleukin-1 receptor antagonist and interleukin-1β

Ploeg, Anke H. van der; Kumpf, Oliver; Seelow, Evelyn; Almanza, Luis C. Berrocal; Schlag, Peter M.; Schumann, Ralf R.; Hamann, Lutz

doi:10.1007/s10120-014-0349-z

Cited by 6 publications

(3 citation statements)

References 35 publications

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“…Studies of familial clustering, ethnic differences and polymorphisms of inflammation-related genes have provided evidence that host genetic factors play a pivotal role in the pathogenesis of gastric cancer [9,10]. The TNF-␣ codifies a potent immunomodulator and pro-inflammatory cytokine that mediates diverse pathological processes [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

TNF-α-308/-238 polymorphisms are associated with gastric cancer: A case-control family study in China

Cao

Jiang

et al. 2017

Clinics and Research in Hepatology and Gastroenterology

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Section: Introductionmentioning

confidence: 99%

TNF-α-308/-238 polymorphisms are associated with gastric cancer: A case-control family study in China

Cao

Jiang

et al. 2017

Clinics and Research in Hepatology and Gastroenterology

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“…Polymorphisms of inflammation-related genes have provided evidence that host genetic factors play a pivotal role in the pathogenesis of GC [5,6]. TNF-α is a potent immunomodulator and pro-inflammatory cytokine that mediates diverse pathological processes [7,8].…”

Section: Introductionmentioning

confidence: 99%

An updated association between TNF-α -238G/A polymorphism and gastric cancer susceptibility in East Asians

Zhao

Liu

et al. 2018

Bioscience Reports

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Polymorphisms in the tumor necrosis factor α (TNF-α) gene are emerging as key determinants of gastric diseases. The TNF-α-238G/A single-nucleotide polymorphism (SNP) is the most extensively studied. However, this association is inconsistent amongst different populations. We therefore conducted an updated meta-analysis to obtain a more precise estimate of the association of TNF-α-238G/A polymorphism with gastric cancer (GC) risk. A comprehensive search of PubMed, Embase, Chinese (CNKI and WanFang) databases was performed to identify relevant studies through 5 May 2018. Odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of the association. Fourteen studies were included in our meta-analysis involving 2999 cases and 4685 controls. There was no significant association between TNF-α-238G/A polymorphism and GC risk in the overall populations. In the subgroup analysis, we found that TNF-α-238G/A polymorphism was associated with the increased risk of GC amongst Asians, especially in Chinese, but not in Caucasians. Subgroup analysis by genotyping methods revealed increased risk for other methods. In conclusion, our present meta-analysis shows that TNF-α-238G/A polymorphism is associated with the risk of GC in East Asian individuals.

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“…It has been demonstrated that GC susceptibility genes, combined with environmental factors, may play an important role in the development of cancer. In 2000, El-Omar [ 7 ] first reported that IL-1β gene polymorphism increased the risk of GC onset, a finding subsequently confirmed by later studies [ 8 – 10 ]. The IL-1β gene is mapped to chromosome 2q14 and has 3 single-nucleotide polymorphisms (SNPs): 31 T/C, 511 C/T, and 3954 C/T.…”

Section: Introductionmentioning

confidence: 93%

Correlation Between Interleukin-1β-511 C/T Polymorphism and Gastric Cancer in Chinese Populations: A Meta-Analysis

et al. 2016

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BackgroundSeveral studies have indicated that interleukin (IL)-1β-511 C/T polymorphism may contribute to individual susceptibility to gastric cancer, but the results vary among regions and races. No relevant meta-analysis has been conducted in a Chinese population. Therefore, we performed the current meta-analysis to investigate the possible correlation between IL-1β-511 C/T polymorphism and gastric cancer susceptibility in Chinese subjects.Material/MethodsPubMed, EmBase, Cochrane Library, Chinese Biology Medicine (CBM), Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases were searched for case-control studies published before 21 January 2015 and investigating a correlation between IL-1β-511 C/T polymorphism and gastric cancer susceptibility. Two investigators independently screened the studies, extracted data, and evaluated the quality of included studies with the Newcastle-Ottawa scale. Meta-analysis was conducted with STATA 12.0.ResultsA total of 27 articles from 28 case-control studies were collected. Meta-analysis showed that IL-1β-511C/T polymorphism was related to increased susceptibility to gastric cancer in Chinese subjects [T vs. C: OR=1.21, 95%CI (1.07–1.37), P<0.01; TT vs. CC: OR=1.41, 95%CI (1.11–1.80), P<0.01; CT vs. CC: OR=1.26, 95% CI (1.05–1.50), P<0.01; TT+CT vs. CC: OR=1.31, 95%CI (1.08–1.58), P<0.01; and TT vs. CT+CC: OR=1.24, 95%CI (1.05–1.47), P<0.01]. Subgroup analysis showed a significant correlation between IL-1β-511C/T polymorphism and susceptibility to gastric cancer in residents of southern China and in patients with intestinal-type gastric cancer, but not in residents of northern China or in patients with diffuse gastric cancer. Moreover, H. pylori-infected subjects carrying T (CT+TT) exhibited a relatively higher risk of GC [OR=2.4, 95% CI (1.2–5.1), P=0.02].ConclusionsIL-1β-511C/T polymorphism is significantly associated with increased susceptibility to gastric cancer in residents of southern China and in intestinal-type gastric cancer. We also found a synergistic interaction between IL-1β-511C/T polymorphism and H. pylori infection in the development of GC.

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The course of gastric cancer following surgery is associated with genetic variations of the interleukin-1 receptor antagonist and interleukin-1β

Cited by 6 publications

References 35 publications

TNF-α-308/-238 polymorphisms are associated with gastric cancer: A case-control family study in China

TNF-α-308/-238 polymorphisms are associated with gastric cancer: A case-control family study in China

An updated association between TNF-α -238G/A polymorphism and gastric cancer susceptibility in East Asians

Correlation Between Interleukin-1β-511 C/T Polymorphism and Gastric Cancer in Chinese Populations: A Meta-Analysis

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