The covariation of trait anger and borderline personality: A bivariate twin-siblings study.

Distel, Marijn A.; Roeling, Mark Patrick; Tielbeek, Jorim J.; Toor, Désie van; Derom, Cathérine; Trull, Timothy J.; Boomsma, Dorret I.

doi:10.1037/a0026393

Cited by 15 publications

(10 citation statements)

References 67 publications

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“…Thus, the pattern of familial aggregation of BPD across different types of relatives indicates that genetic factors play a significant role in the risk of developing BPD, and explain the familial clustering of the disorder. Previous heritability estimates vary widely [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] and our results represent a substantial improvement in precision, based on our sample size and the number of BPD-diagnosed individuals, as reflected in the narrow confidence intervals for the heritability estimates. Furthermore, our findings indicate that close family members of individuals represent an important high-risk group for developing BPD; and that this is due to genetic, and not environmental, influences.…”

Section: Discussionmentioning

confidence: 48%

“…This study has several important strengths including utilizing Swedish nationwide register linkages. Previous studies are often limited by small sample sizes [7-10, 13-16, 19, 34, 36] the use of BPD-traits rather than diagnosis [7, 9, 10, 19-24, 28, 29, 31-33, 35-37, 64], and selfrating questionnaires [16,19,[21][22][23][24][25][26][27][28]30] rather than clinical diagnoses, exposing them to risks of low statistical power, selection-and recall bias. This register-based population cohort provided large sample-size, wellidentified biological relatives, extensive follow-up time, and clinical diagnoses.…”

Section: Discussionmentioning

confidence: 99%

“…Twin and extended twin studies, including relatives of twins, enable exploration of the relative contribution of genetic and environmental factors to familial aggregation [18]. Previous studies investigating the genetic impact of BPD show widely ranging heritability estimates, from 0 to 72% [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37]. Among the population-based studies only seven ascertained case status by clinical interviews [20, 29, 31-33, 35, 37] narrowing down heritability to 32 to 72%.…”

Section: Introductionmentioning

confidence: 99%

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Familial risk and heritability of diagnosed borderline personality disorder: a register study of the Swedish population

et al. 2019

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Family and twin studies of Borderline Personality Disorder (BPD) have found familial aggregation and genetic propensity for BPD, but estimates vary widely. Large-scale family studies of clinically diagnosed BPD are lacking. Therefore, we performed a total-population study estimating the familial aggregation and heritability of clinically diagnosed BPD. We followed 1,851,755 individuals born 1973-1993 in linked Swedish national registries. BPD-diagnosis was ascertained between 1997 and 2013, 11,665 received a BPD-diagnosis. We identified relatives and estimated sex and birth year adjusted hazard ratios, i.e., the rate of BPD-diagnoses in relatives to individuals with BPD-diagnosis compared to individuals with unaffected relatives, and used structural equation modeling to estimate heritability. The familial association decreased along with genetic relatedness. The hazard ratio was 11.5 (95% confidence interval (CI) = 1.6-83.8) for monozygotic twins; 7.4 (95% CI = 1.0-55.3) for dizygotic twins; 4.7 (95% CI = 3.9-5.6) for full siblings; 2.1 (95% CI = 1.5-3.0) for maternal halfsiblings; 1.3 (95% CI = 0.9-2.1) for paternal half-siblings; 1.7 (95% CI = 1.4-2.0) for cousins whose parents were full siblings; 1.1 (95% CI = 0.7-1.8) for cousins whose parents were maternal half-siblings; and 1.9 (95% CI = 1.2-2.9) for cousins whose parents were paternal half-siblings. Heritability was estimated at 46% (95% CI = 39-53), and the remaining variance was explained by individually unique environmental factors. Our findings pave the way for further research into specific genetic variants, unique environmental factors implicated, and their interplay in risk for BPD.

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Section: Discussionmentioning

confidence: 48%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Familial risk and heritability of diagnosed borderline personality disorder: a register study of the Swedish population

et al. 2019

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“…The undersigned agree to abide by the statements above. .............................................................................................................& 18& Figure&3.2,&Measurement&Models&for&Latent&Anger,&Anger&Rumination&and&BPD&& &&&&&&&&&&&&&&&&&&&Variables&Used&in&Structural&Model&.................................................................& 19& Figure&3.3,&Structural&Model&Predicting&BPD&Features&from&Shame&via&Anger&and&Anger&& &&&&&&&&&&&&&&&&&&&Rumination&......................................................................................................& (Distel,&2011).&& Although&less&emphasized&in&the&DSM&(APA,&2000),&shamePproneness&is&widely& believed&to&be&characteristic&of&people&with&BPD& (Linehan,&1993).&A&small&literature& suggests&that&people&with&BPD&experience&high&levels&of&shame&(Rüsch&et&al.,&2007),&and& that&shame&predicts&severity&of&symptoms&associated&with&BPD,&including&selfPharm& (Brown,&Linehan,&Comtois,&Murray,&&&Chapman,&2009) (demonstrated(good(fit((χ 2( =(8.67,(df(=(2,(p(<(.05;(RMSEA(=(.06,(CFI(=( .99),(with(all(four(subscales(loading(significantly(onto(the(latent(variable((.79M.87,(p( <.001). (The(measurement(model(for(an(anger(latent(variable(with(loadings(from(the( PANAS(anger(subscale,(the(AQ(Anger(subscale(and(the(AQ(Hostility(subscale( demonstrated(excellent(fit((χ 2( =(0.026,(df(=(1,(p(=(.87;(RMSEA(=(.00,(CFI(=(1.00),(with(all( subscales(loading(significantly(onto(the(latent(variable((.66M.68,(p(<.001).…”

Section: Review Approval and Acceptance Review Approval And Acceptancementioning

confidence: 99%

Shame and borderline personality features: The potential mediating role of anger and anger rumination.

Peters¹,

Geiger²,

Smart³

et al. 2014

Personality Disorders: Theory, Research, and Treatment

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Two prominent emotions in borderline personality disorder (BPD) are shame and anger. Rumination has been demonstrated to occur in response to shame and to escalate anger, and rumination, particularly anger rumination, has been shown to predict BPD symptoms. The present study tested a structural equation model in which shame leads to the features of BPD via increased anger and anger rumination. A sample of 823 undergraduates completed self-report measures of shame, trait-level anger, anger rumination, and BPD features. The hypothesized model of shame to anger and anger rumination to BPD features was largely supported. Bootstrapping was used to establish significant indirect effects from both situational and global forms of shame via anger rumination to BPD features, and from global shame via anger to most BPD features. The alternative hypothesis that anger and anger rumination contribute to BPD features via increased shame was also examined, with no significant indirect effects found. Recognizing this function of anger and anger rumination may be important in understanding the relationship between shame-proneness and BPD features and may have implications for treatment. Further research into determining other ways individuals maladaptively respond to shame, and understanding the functions of anger and anger rumination, is recommended.

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“…High levels of trait anger predict quite a few health outcomes (Robinson et al, 2012 ). For example, angry individuals suffer from excessive cardiovascular reactivity (Suarez et al, 1998 ), higher blood pressure (Suls et al, 1995 ), many other physical problems (Williams et al, 2002 ), and psychological health problems, such as borderline personality (Distel et al, 2012 ), attempted suicide (Daniel et al, 2009 ). Especially, angry individuals damage their social relationships (Baron et al, 2007 ), receive less social support (Smith et al, 2004 ), and have high divorce rate (Roberts et al, 2007 ).…”

Section: Introductionmentioning

confidence: 99%

The trait anger affects conflict inhibition: a Go/Nogo ERP study

Liu

Zhan

Wei

et al. 2015

Front. Hum. Neurosci.

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To explore the time course of inhibitory control in high trait anger individuals, we recorded and analyzed ERP data relevant to visual Go/Nogo task in high and low trait anger participants. Compared with low trait anger participants, high trait anger participants revealed faster RTs in the Go/Nogo task. The nogo effect of N2 related to conflict monitoring was similar between two groups. While the P3go was larger in high than low trait anger groups, the P3nogo did not differ between two groups. This induced the smaller nogo effect of P3 in high than that in low trait anger group, which is closely related to the actual inhibition of the motor system. These data suggest the reduced later stage of inhibitory processes in high trait anger individuals, implicating the dysfunction of inhibitory control.

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The covariation of trait anger and borderline personality: A bivariate twin-siblings study.

Cited by 15 publications

References 67 publications

Familial risk and heritability of diagnosed borderline personality disorder: a register study of the Swedish population

Familial risk and heritability of diagnosed borderline personality disorder: a register study of the Swedish population

Shame and borderline personality features: The potential mediating role of anger and anger rumination.

The trait anger affects conflict inhibition: a Go/Nogo ERP study

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