The covert transmittance enhancement effect of terahertz metamaterials coupling with vapor

Chen, Kanglong; Wen, Lianggong; Wang, Ziyang; Wu, Xianhao; Fahad, Ayesha Kosar; Ruan, Cunjun

doi:10.1016/j.sna.2022.114147

Cited by 4 publications

(3 citation statements)

References 43 publications

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“…The measurement results exhibit some variations in amplitude within transmission curves, while the overall envelope closely agrees with simulation results, except for a resonance dip at around 1.5 THz. This dip remains elusive due to its high Q-factor and the limited scanning time during measurement imposed by the substrate thickness [12].…”

Section: Integration Of Biosensor Chipmentioning

confidence: 99%

“…Biosensors 2024, 14, x FOR PEER REVIEW 3 of 12 resonance dip at around 1.5 THz. This dip remains elusive due to its high Q-factor and the limited scanning time during measurement imposed by the substrate thickness [12].…”

Section: Integration Of Biosensor Chipmentioning

confidence: 99%

“…For example, Li (2021) [9] used an MMs-based THz biosensor to identify early-stage cervical cancerous tissues. Chen (2023) [10] employed an MMs-based THz biosensor to detect the low-concentration dried GBM cells deposited on the surface of MMs. Zhang (2018) [11] proposed an MMs-based THz biosensor to analyze the apoptosis of dried cancer cells cultured on the surface of MMs.…”

Section: Introductionmentioning

confidence: 99%

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Detection of In Vivo-like Cells by a Biosensor Chip Based on Metamaterials in Terahertz Regime

Han,

Wang,

Chen

et al. 2024

Biosensors

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Early diagnosis of diseases, especially cancer, is critical for effective treatment. The unique properties of terahertz technology have attracted attention in this field. However, current terahertz bio-detection methods face challenges due to differences between the test environment and the actual in vivo conditions. In this study, a novel method is proposed for detecting in vivo-like cells using a biosensor chip composed of metamaterials and a cavity. The cavity has a thickness of ~50 μm. The structure can protect cells from damage and provides a liquid environment like an in vivo state. Through simulation analysis, the metamaterials sensor exhibits a theoretical sensitivity of 0.287 THz/RIU (Refractive Index Unit) with a 50 μm thick analyte. The detection method is experimentally validated using the apoptosis of glioma cells and various cell types. The biosensor investigates the apoptosis of glioma cells under the impact of temozolomide, and the trend of the results was consistent with the Cell Counting Kit-8 method. Furthermore, at a concentration of ~5200 cells/cm2, the experimental results demonstrate that the sensor can distinguish between neurons and glioma cells with a resonance frequency difference of approximately 30 GHz. This research has significant potential for detecting glioma cells and offers an alternative approach to in vivo-like cell detection.

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Section: Integration Of Biosensor Chipmentioning

confidence: 99%

Section: Integration Of Biosensor Chipmentioning

confidence: 99%