The covid-19 elimination debate needs correct data

Baker, Michael G; Wilson, Nick

doi:10.1136/bmj.m3883

Cited by 8 publications

(6 citation statements)

References 6 publications

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“…However, rather than single-center data alone, the COVID-19 pandemic has underlined the need for accurate and verifiable multicenter data [ 7 , 8 ]. The novelty of COVID-19 and absence of treatment guidelines resulted in practice variation between centers, emphasizing the limits of single-center research and the need for multicenter research into effective treatment strategies [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

The Dutch Data Warehouse, a multicenter and full-admission electronic health records database for critically ill COVID-19 patients

Fleuren

Dam

Tonutti³

et al. 2021

Crit Care

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Background The Coronavirus disease 2019 (COVID-19) pandemic has underlined the urgent need for reliable, multicenter, and full-admission intensive care data to advance our understanding of the course of the disease and investigate potential treatment strategies. In this study, we present the Dutch Data Warehouse (DDW), the first multicenter electronic health record (EHR) database with full-admission data from critically ill COVID-19 patients. Methods A nation-wide data sharing collaboration was launched at the beginning of the pandemic in March 2020. All hospitals in the Netherlands were asked to participate and share pseudonymized EHR data from adult critically ill COVID-19 patients. Data included patient demographics, clinical observations, administered medication, laboratory determinations, and data from vital sign monitors and life support devices. Data sharing agreements were signed with participating hospitals before any data transfers took place. Data were extracted from the local EHRs with prespecified queries and combined into a staging dataset through an extract–transform–load (ETL) pipeline. In the consecutive processing pipeline, data were mapped to a common concept vocabulary and enriched with derived concepts. Data validation was a continuous process throughout the project. All participating hospitals have access to the DDW. Within legal and ethical boundaries, data are available to clinicians and researchers. Results Out of the 81 intensive care units in the Netherlands, 66 participated in the collaboration, 47 have signed the data sharing agreement, and 35 have shared their data. Data from 25 hospitals have passed through the ETL and processing pipeline. Currently, 3464 patients are included in the DDW, both from wave 1 and wave 2 in the Netherlands. More than 200 million clinical data points are available. Overall ICU mortality was 24.4%. Respiratory and hemodynamic parameters were most frequently measured throughout a patient's stay. For each patient, all administered medication and their daily fluid balance were available. Missing data are reported for each descriptive. Conclusions In this study, we show that EHR data from critically ill COVID-19 patients may be lawfully collected and can be combined into a data warehouse. These initiatives are indispensable to advance medical data science in the field of intensive care medicine.

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Section: Introductionmentioning

confidence: 99%

The Dutch Data Warehouse, a multicenter and full-admission electronic health records database for critically ill COVID-19 patients

Fleuren

Dam

Tonutti³

et al. 2021

Crit Care

View full text Add to dashboard Cite

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“…COVID-19 is considered to have a much lower mortality rate than SARS or MERS (Petersen et al, 2020) (Table 1). In contrast, the COVID-19 infection is reported to be more fatal than influenza (Baker, 2020). Studies in France and the USA report that the in-hospital mortality rate among patients hospitalized for COVID-19 was much higher compared to that for influenza after adjusting for potential risk factors (Piroth et al, 2020;Xie et al, 2020).…”

Section: Pathogenesis and Prognosismentioning

confidence: 97%

Health and Public Health Implications of COVID‐19 in Asian Countries

Miyawaki

2021

Asian Economic Policy Review

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This paper discusses the impacts of the COVID-19 pandemic on population health in Asian countries. Compared to European countries, Asian countries, in general, experienced much fewer COVID-19 cases and deaths. The underlying factors in this difference would include the earlier and more stringent nonpharmaceutical interventions, differences in the age structure, the geographical characteristics in Asia, and the experience of past outbreaks of emerging diseases, though further studies are needed to investigate the exact mechanisms. Still, regarding the aim of developing resilient health care systems, there remain several lessons from the COVID-19 pandemic experience in Asian countries that could inform more effective management of future pandemics.

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“…The influenza benchmark has been important during the COVID-19 pandemic (Baker and Wilson 2020;Lee et al 2020). The COVID-19 infection fatality rate was initially estimated at nearly seven times that of seasonal influenza (Verity et al 2020); coupled with an estimated R0 between 2.0 and 2.6, some models predicted the impending collapse of health systems (Ferguson et al 2020).…”

Section: Life Expectancy Mattersmentioning

confidence: 99%

Herd Immunity: History, Concepts, and Ethical Rationale

Vecchi¹,

Airoldi²

2023

Perspectives in Biology and Medicine

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Public health emergencies are fraught by epistemic uncertainty, which raises policy issues of how to handle that uncertainty and devise sustainable public health responses. Among such responses, a herd immunity policy might be an option. Particularly before the development of vaccines, the current COVID-19 pandemic has highlighted the polarized nature of the political debate concerning the ethical feasibility of herd immunity strategies. This article provides a conceptual framework tailored to uncover the ethical rationale behind such strategies. Clarity on this issue is important in order to facilitate the terms of the political debate when tackling future health emergencies.

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The covid-19 elimination debate needs correct data

Cited by 8 publications

References 6 publications

The Dutch Data Warehouse, a multicenter and full-admission electronic health records database for critically ill COVID-19 patients

The Dutch Data Warehouse, a multicenter and full-admission electronic health records database for critically ill COVID-19 patients

Health and Public Health Implications of COVID‐19 in Asian Countries

Herd Immunity: History, Concepts, and Ethical Rationale

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