“…The roles of active plant-derived ingredients or plantbased foods in disease prevention and health enhancement have widely been examined (Zhang et al, 1992;Avorn et al, 1994;Seddon et al, 1994;Clinton et al, 1996;Howell et al, 1998;Brown et al, 1999;Chasan-Taber et al, 1999;Keevil et al, 2000;Meister et al, 2000;Chen et al, 2001;Leahy et al, 2001;Mares-Perlman et al, 2002). Fruits such as cranberries (Avorn et al, 1994;Howell et al, 1998;Leahy et al, 2001;Starling, 2004), grapes (Keevil et al, 2000;Meister et al, 2000) and tomato (Seddon et al, 1994;Clinton et al, 1996;Brown et al, 1999;Chasan-Taber et al, 1999;Chen et al, 2001;Mares-Perlman et al, 2002) have demonstrated moderately strong evidence of clinical efficacy presumably because of their beneficial constituents. Not surprisingly, these results have fostered a substantial demand for an increased variety of functional food ingredients with health-promoting properties made entirely from fruits.…”